Post weaning high fat feeding affects rats' behavior and hypothalamic pituitary adrenal axis at the onset of puberty in a sexually dimorphic manner

Boukouvalas, George; Αντωνίου, Κατερίνα; Papalexi, E.; Kitraki, Efthimia

doi:10.1016/j.neuroscience.2008.02.023

Cited by 45 publications

(43 citation statements)

References 57 publications

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“…MR harbors a neuroprotective function in the hippocampus (46), while GR is a typical target of neuronal signaling that is sensitive and vulnerable to GC and its over-activation would damage hippocampal neurons (45,47), which may lead to behavioral alterations. For instance, HFD administered from post-weaning age until puberty was found to decrease the hippocampal GR protein expression in female rats (6). In the present study, hippocampal MR mRNA levels showed an increasing tendency after CMS, while GR expression was significantly reduced in the HFD group, increasing the MR/GR ratio.…”

Section: Discussionsupporting

confidence: 54%

“…The high-fat rat diet used in the present study (24% fat) mimics the HFD consumed by humans (6,7). Previous studies have shown that women are more prone to mental diseases after HFD and exhibit a higher sensitivity to CMS than men (27), which is why only female rats were assessed in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…A HFD during adolescence has also been shown to increase the blood corticosterone (CORT) levels and expression of glucocorticoid receptors (GRs) in the hypothalamus and hippocampus (6,7). The activity of the hypothalamic-pituitary-adrenal (HPA) axis is modulated by a feedback regulation of GCs and adrenocorticotropic hormone (ACTH) at the levels of the hippocampus, paraventricular nucleus of hypothalamus and pituitary gland.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, maternal HFD during pregnancy modulates glucocorticoid signaling pathways in limbic areas, and is associated with the regulation of HPA function and anxiety in adulthood (13). A post-weaning HFD until early puberty leads to altered HPA axis function in female rats, indicating that HFD-induced nutritional imbalance in young females may lead to neuroendocrine dysfunction, which in turn may promote the appearance of stress-associated disorders during adolescence (6). Chronic mild stress (CMS) is often associated to the pathogenesis of obesity (14).…”

Section: Introductionmentioning

confidence: 99%

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Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress

Yang

Qian

2017

Experimental and Therapeutic Medicine

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Abstract.A high-fat diet (HFD) is highly correlated to obesity, metabolic diseases and certain behavioral changes. However, the effects of post-weaning HFD in rats during puberty and the role of the hypothalamic-pituitary-adrenal (HPA) axis in this process have remained elusive. The present study hypothesized that the HPA axis mediates the behavioral alterations induced by a post-weaning HFD. To investigate this, female rats were divided into two groups, one of which was fed a HFD from postnatal weeks (PWs) 4-12, while the other group received standard chow. Rats in each group were then subdivided into two subgroups each, and from PW 9-12, animals from one of the two subgroups were subjected to chronic mild stress (CMS), while the other subgroup received no stress. At PW 12, the body weight of rats receiving a HFD but no DMS was significantly higher than that in the control group. The frequency of crossing and rearing in the open field test and the time in the center of the Y-maze were decreased following CMS. Total time to escape was decreased in rats receiving HFD and after CMS. The serum levels of adrenocorticotropic hormone and corticosterone were increased in rats receiving an HFD and after CMS, and the mRNA levels of corticotropin-releasing hormone and arginine vasopressin in the hypothalamus were increased in the HFD + CMS group compared to that in the control group. The mRNA expression of glucocorticoid receptor (GR) in the hippocampi of rats in the HFD + CMS group was significantly decreased and the mineralocorticoid receptor/GR ratio was increased compared to that in the groups receiving either CMS or a HFD. In conclusion, these results indicated that female rats fed a post-weaning HFD showed HPA axis hypersensitivity under CMS, which may mediate behavioral alterations.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress

Yang

Qian

2017

Experimental and Therapeutic Medicine

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“…These data indicate that persistent energy excess during early postnatal development might contribute to a precocious activation of the hypothalamic control of puberty. Independently of the calorie amount, quality of the diet might affect the onset of puberty (Boukouvalas et al, 2008;Fungfuang et al, 2013;Li et al, 2012). High fat diet during gestation or after weaning induces early onset of puberty in females though weight is not significantly different from the control group.…”

Section: Peripubertal Food Restrictionmentioning

confidence: 99%

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Parent

Franssen

Fudvoye

et al. 2015

Frontiers in Neuroendocrinology

156

140

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Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such distortion of distribution is a recent phenomenon. This suggests changing environmental influences including the possible role of nutrition, stress and endocrine disruptors. Our ability to assess neuroendocrine effects and mechanisms is very limited in humans. Using the rodent as a model, we examine the impact of environmental factors on the individual variations in pubertal timing and the possible underlying mechanisms. The capacity of environmental factors to shape functioning of the neuroendocrine system is thought to be maximal during fetal and early postnatal life and possibly less important when approaching the time of onset of puberty.

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Lipids, Weight Gain and Obesity

Deng¹,

Li²,

Lei³

2020

Bailey's Industrial Oil and Fat Products

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Epidemiological studies have demonstrated that the prevalence of chronic diseases such as diabetes, cardiovascular diseases, and certain types of cancers are mainly induced by body weight gain and obesity. It is recognized that excess calorie intake and reduced physical activity are the fundamental causes for weight gain and obesity, among which dietary lipids have been correlated with increases in body mass index. An increasing attention has focused on dietary lipids, both quantity and quality, to prevent the development of obesity. The first part of this article introduces the contemporary understanding of dietary lipids in weight gain and obesity, including the transcriptional factors, namely, sterol regulatory element‐binding proteins (SREBPs) and peroxisome proliferator‐activated receptors (PPARs), involved in fatty acids metabolism. The second part reviews the role of overweight and obesity in chronic diseases, with focus on the underlying mechanism of obesity‐induced inflammation, type 2 diabetes, cardiovascular diseases, and cancers.

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Post weaning high fat feeding affects rats' behavior and hypothalamic pituitary adrenal axis at the onset of puberty in a sexually dimorphic manner

Cited by 45 publications

References 57 publications

Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress

Hypothalamic-pituitary-adrenal axis hypersensitivity in female rats on a post-weaning high-fat diet after chronic mild stress

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Lipids, Weight Gain and Obesity

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