Post-treatment late complications of nasopharyngeal carcinoma

Abstract

Radiotherapy (RT) or concurrent chemoradiation therapy (CCRT) is not only effective at patients' survival rates, but also produces undesirable late complications. The purpose of this study is to investigate the post-treatment late complications in nasopharyngeal carcinoma (NPC) patients, and to analyze the individual impact factors. We enrolled 188 newly diagnosed NPC patients who had received complete treatments and at least 3 years' follow-up between March 1984 and March 2010. Late complications were modified from the Toxicity Criteria of the Radiation Therapy Oncology Group and the European Organization for Research and Treatment of Cancer. Of 188 patients, 132 were male and 56 were female. Eighty-eight patients received CCRT and the other 100 patients received RT alone. The median follow-up duration was 7.34 years (range 3.30-26.54). Only 5.3% of patients reported no complication during post-treatment follow-up. The most common major and minor complications were osteoradionecrosis (10.1%) and xerostomia (56.4%), respectively. There was no impact factor for age, underlying disease, and cancer staging. However, there was a negative impact factor for xerostomia and limb numbness in the CCRT group compared with the RT group. Besides, re-radiation for recurrent patients could increase the risk of major complications. Fortunately, these major complications were reduced after the introduction of intensity-modulated radiotherapy in 2003. The improvement of treatment modality decreased the risk of major complications. Physicians should pay more attentions and improve patients' quality of life during follow-up.

Postirradiated carotid blowout syndrome in patients with nasopharyngeal carcinoma: A case–control study

“…With the advancement of radiation techniques and combination with chemotherapy, excellent long‐term survival can be achieved in most patients without metastatic diseases . However, late treatment toxicity has become an important issue among survivors . Carotid blowout syndrome, the rupture of the carotid artery or one of its main branches, is an uncommon but devastating complication of irradiated NPC.…”

CT-Guided 125 I Brachytherapy for Locally Recurrent Nasopharyngeal Carcinoma

“…The QoL scores were closely related to radiotherapy-induced acute complications. Over time, the gradual emergence of long-term complications caused by re-irradiation reduced the positive impact on clinical symptoms by decreasing QoL (38) .…”

Biomarkers for Use in Monitoring Responses of Nasopharyngeal Carcinoma Cells to Ionizing Radiation

“…Further, radiation treatment usually accompanies with undesirable complications including xerostomia, limb numbness, temporal lobe necrosis and neuropathy which increase the medical comorbidity and medical expenses [66]. In case of treatment failure, local recurrence is usually observed.…”