Post-traumatic inflammatory pseudotumor of the breast with atypical morphological features: A potential diagnostic pitfall. Report of a case and a critical review of the literature

Vecchio, Giada Maria; Amico, Paolo; Grasso, Giuseppe; Vasquez, Enrico; G, La Greca; Magro, Gaetano

doi:10.1016/j.prp.2011.01.009

Cited by 44 publications

(35 citation statements)

References 30 publications

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“…Moreover, all the IMTs were unilateral and surgically excised. However, three showed recurrence following surgery, with two of the three patients having bilateral recurrence (30). With regard to our case, the tumor showed local recurrence 3 and 7 months after surgery.…”

Section: Discussionmentioning

confidence: 45%

Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: A case report

Zhao¹,

Wang

et al. 2012

Oncology Letters

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Abstract. Primary inflammatory myofibroblastic tumor (IMT) of the breast is extremely rare; only 19 cases have been reported in the English literature. In the present study, we present a case of IMT in a 56-year-old female patient who was admitted to our hospital due to a mass found in her right breast. Mammogram and ultrasound revealed a well-circumscribed mass and surgery was performed. Histopathologically, the lesion was composed of spindle and inflammatory cells, including plasma cells and lymphocytes. Mitotic figures were not observed. Immunohistochemically, the tumor cells were positive for SM-actin, anaplastic lymphoma kinase (ALK) and vimentin and focal positive for desmin, but negative for NSE, S-100, CD117, CD34, NF, CD21, CD35 and CD68. Thus, we made a diagnosis of IMT and advised regular follow-up. However, the patient had local recurrence and metastasis to the left groin area 3, 7 and 10 months after the initial surgery. Notably, the histopathological characteristics of the recurrent and metastatic foci were similar to those of the initial specimen, but mitotic figures were clearly observed. Thus, we conclude that IMT shows occasionally malignant biological behavior although it is a neoplasm of intermediate biological potential that frequently recurs and rarely metastasizes. We advise that clinical physicians should regularly follow up patients after focal resection for IMT.

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Section: Discussionmentioning

confidence: 45%

Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: A case report

Zhao¹,

Wang

et al. 2012

Oncology Letters

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“…All these cases occurred spontaneously without any apparent prior injury. The first case of a posttraumatic IPT has recently been reported by Vecchio et al in a 22-year-old male [3]. We present another female patient with this unusual tumour entity of the breast and discuss the unique appearance and clinical behaviour of IMTs among the group of spindle-cell breast lesions.…”

mentioning

confidence: 66%

“…3). Other than that the tumour was composed of macrophages intensely expressing CD14 [5] 60, female IMT -24 months no recurrence 1 [6] 53, female IMT -NA no recurrence 1 [3] 22, male IP -NA no recurrence 1 [7] 46, female and CD68 as well as CD3-positive T-lymphocytes with an admixture of scattered CD-20 positive B-lymphocytes. Immunohistochemistry for the pan-cytokeratin markers AE1/3 and E-Cadherin was negative.…”

mentioning

confidence: 98%

23-Year-Old Female with an Inflammatory Myofibroblastic Tumour of the Breast: A Case Report and a Review of the Literature

Bosse

Ott

Biegner

et al. 2014

Geburtshilfe Frauenheilkd

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!Purpose: Inflammatory myofibroblastic tumours (IMT) are a subcategory of inflammatory pseudotumours (IPT). They arise most commonly in the abdominopelvic region, lung and retroperitoneum, but virtually any anatomical site may be involved. Predominantly children and adolescents are affected and there is a tendency for local recurrence. In the literature up to the present, 20 patients have been reported with an IPT/IMT of the breast. We would like to present another patient with this unusual tumour entity of the breast and discuss the literature. Patient and Examinations: A 23-year-old woman presented with a painless lump in her left breast. There was no history of breast cancer in her family. Sonography showed a hypoechoic heterogeneous solid mass with irregular margins. A core needle biopsy revealed a tumour of high cellularity and a densely collagenous background. Immunohistochemically, the spindle-shaped cells were immunoreactive to smooth muscle actin and ALK-1 protein. Additional FISH analysis proved ALK rearrangements on chromosome 2p23 leading to the diagnosis of an IMT. Wide surgical excision was performed with no evidence of local recurrence after 12 months. Conclusion: Three of the above mentioned 20 patients with IMT/IPT of the breast developed a recurrent tumour, none presented with distant metastasis. A significant recurrence rate of 15 % leads to a clinically and sonographically close follow-up in these patients. Zusammenfassung

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“…Unlike myofibroblastoma, fibromatosis exhibits infiltrative, at least focally, margins, entraps fat and glandular breast tissue, and the neoplastic cells lack diffuse expression of desmin, CD34, oestrogen/ progesterone receptors and bcl-2 protein [20][21][22][23] . Inflammatory myofibroblastic pseudotumour is a fibroinflammatory lesion which can be rarely encountered in the breast parenchyma 24 . It is composed of spindle-shaped cells arranged in a fascicular, and less frequently, storiform growth pattern.…”

Section: Discussionmentioning

confidence: 99%

“…It is composed of spindle-shaped cells arranged in a fascicular, and less frequently, storiform growth pattern. Unlike fibromatosis, this reactive lesion contains a significant component of inflammatory cells, including plasma cells, lymphocytes and eosinophils 24 . Although it shows immunoreactivity for -smooth muscle actin, ALK-1 protein is expressed in about 40%-50% of cases, while β-catenin, a marker which is typically found in most cases of fibromatosis, is not expressed.…”

Section: Discussionmentioning

confidence: 99%

Fibromatosis of the breast parenchyma with a benign-like nodular appearance

Salvatorelli¹,

Musumeci²,

Vecchio³

et al. 2013

OA Case Reports

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Post-traumatic inflammatory pseudotumor of the breast with atypical morphological features: A potential diagnostic pitfall. Report of a case and a critical review of the literature

Cited by 44 publications

References 30 publications

Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: A case report

Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: A case report

23-Year-Old Female with an Inflammatory Myofibroblastic Tumour of the Breast: A Case Report and a Review of the Literature

Fibromatosis of the breast parenchyma with a benign-like nodular appearance

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