Post-transplantation swelling of the lower eyelid

Koenig, Kai; Briese, Sonia; Wiemann, Dagobert; Haffner, Dieter; Querfeld, Uwe

doi:10.1093/ndt/gfg597

Cited by 2 publications

(1 citation statement)

References 10 publications

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“… 4 , 5 A few case reports also described the possibility of an orbital involvement. 6 , 7 In the literature, posterior involvement includes vitritis, 8 , 9 subretinal masses 5 , 10 and optic disc swelling. 5 , 10 , 11 …”

Section: Discussionmentioning

confidence: 99%

Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement

Adam

Philippakis

Galy

et al. 2021

American Journal of Ophthalmology Case Reports

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Purpose Post-transplant lymphoproliferative disorder (PTLD) represents a spectrum of disorders associated with Epstein Barr Virus infection in up to 80% of cases in the setting of pharmacologic immunosuppression following hematopoietic stem cell or solid organ transplantation. Ocular involvement is a rare finding in PTLD. Observation We report the case of a 38-year-old man who presented with unilateral retinal infiltrates as first manifestation of PTLD relapse. Diagnosis relied on the presence of EBV DNA in anterior chamber fluids and vitrectomy that showed the presence of a B cell clone. Systemic relapse of PTLD was detected 12 weeks after retinal findings. Treatment of ocular disease included systemic injections of rituximab and intravitreal injections of methotrexate, halting the extension of retinal infiltrates. Conclusion Ocular involvement in PTLD is rare and needs to be acknowledged because it can precede a systemic relapse of the hematological condition.

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