Post‐transplant lymphoproliferative disorder after pediatric liver transplantation: Characteristics and outcome

Fernández, María Concepción López; Bes, David; Dávila, M; López, Susana; Cambaceres, Carlos; Dip, Marcelo; Imventarza, Oscar

doi:10.1111/j.1399-3046.2008.00914.x

Cited by 51 publications

(42 citation statements)

References 15 publications

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“…In the present study, the mortality rate reached 25%. Fernandez et al have found a mortality rate of 18% in a similar population (11) . Finally, lymphomas are relatively uncommon and potentially fatal complications that may occur at any moment after liver transplant in children and that present variable clinical and imaging findings.…”

Section: Studies In Patients Submitted To Hepatic Transplantation Havmentioning

confidence: 99%

“…In the study developed by Fernandez et al, who have also evaluated Radiol Bras. 2012 Jan/Fev;45(1):7-11 children submitted to liver transplant, the mean time elapsed between the transplant and development of the disease was 25 months, ranging from seven to 47 months (11) . Age at the moment of the transplantation was the sole risk factor for development of lymphoma observed in the present study, which may be associated with previous contact of the patients with the Epstein-Barr virus (EBV).…”

Section: Studies In Patients Submitted To Hepatic Transplantation Havmentioning

confidence: 99%

“…In the literature, the incidence of PTLD in pediatric patients submitted to liver transplant ranges from 4% to 15% (11,12) .…”

Section: Studies In Patients Submitted To Hepatic Transplantation Havmentioning

confidence: 99%

“…2012 Jan/Fev;45(1): [7][8][9][10][11] ing findings, the radiologist plays a relevant role in the collection of material for histopathological analysis by means of imageguided percutaneous biopsy and in the evaluation of the treatment response . Despite the fact that some studies have already evaluated the incidence and clinical presentation of PTLD (8)(9)(10)(11) , few authors have approached the imaging findings associated with this disease. The present study was aimed at evaluating the incidence and imaging findings of lymphomas after liver transplantation in children.…”

Section: Introductionmentioning

confidence: 99%

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Incidência e aspectos de imagem do linfoma pós-transplante hepático em crianças

et al. 2012

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Objective: To evaluate the incidence and imaging findings of lymphoma after liver transplantation in children. Materials and Methods: The authors reviewed records and imaging studies of children submitted to liver transplantation in the period between 2000 and 2008 in a single institution. Results: Among 241 children submitted to liver transplantation, with a mean follow-up period of 41.4 ± 26.4 months, 16 (6.6%) had lymphoma. The mean age of the patients who developed lymphoma at the moment of transplantation was lower than in children who did not develop malignancy (23.9 ± 18.9 versus 38.0 ± 48.9 months; p = 0.02). The time interval between liver transplantation and the diagnosis of lymphoma ranged from 6 to 103 months. Clinical and radiological presentation was variable and the abdomen was the most common location of the tumor (n = 13; 81.3%), followed by chest and head and neck (n = 4; 25.0% each). Imaging findings included adenopathy, mediastinal, pulmonary and mesenteric masses, bowel wall thickening and hepatic and renal nodules. Four children (25.0%) died because of complications of lymphoma. Conclusion: Lymphomas are relatively uncommon and potentially fatal complications that may occur any time after pediatric liver transplantation, presenting different clinical and imaging findings. Keywords: Lymphoma; Hepatic transplantation; Pediatrics; Imaging diagnosis; Postoperative complications.Objetivo: Avaliar a incidência e os aspectos de imagem do linfoma pós-transplante hepático em crianças. Materiais e Métodos: Foram revisados os prontuários e exames de imagem de crianças submetidas a transplante hepático entre 2000 e 2008 em uma única instituição. Resultados: De 241 crianças submetidas a transplante hepático, com seguimento médio de 41,4 ± 26,4 meses, 16 (6,6%) tiveram linfoma. A média de idade no transplante hepático das crianças que desenvolveram linfoma foi inferior à das crianças que não desenvolveram (23,9 ± 18,9 vs. 38,0 ± 48,9 meses; p = 0,02). O tempo entre o transplante e o desenvolvimento do linfoma variou de 6 a 103 meses. A apresentação clínica e radiológica foi variável e a localização mais comum do tumor foi no abdome (n = 13; 81,3%), seguida de tórax e cabeça e pescoço (n = 4; 25,0% cada). Os achados de imagem incluíram: linfonodomegalias, massas mediastinais, pulmonares e mesentéricas, espessamento parietal de alças intestinais e nódulos hepáticos e renais. Quatro crianças (25,0%) faleceram devido a complicações do linfoma. Conclusão: Linfomas são complicações relativamente incomuns e potencialmente fatais que podem acontecer a qualquer momento após o transplante hepático em crianças, e que têm diversas apresentações clínicas e de imagem. Unitermos: Linfoma; Transplante hepático; Pediatria; Diagnóstico por imagem; Complicações pós-operatórias. AbstractResumo

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Section: Studies In Patients Submitted To Hepatic Transplantation Havmentioning

confidence: 99%

Section: Studies In Patients Submitted To Hepatic Transplantation Havmentioning

confidence: 99%

“…In the literature, the incidence of PTLD in pediatric patients submitted to liver transplant ranges from 4% to 15% (11,12) .…”

Section: Studies In Patients Submitted To Hepatic Transplantation Havmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidência e aspectos de imagem do linfoma pós-transplante hepático em crianças

et al. 2012

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“…Outcomes for children with PTLD are much better than for adults. (Dharnidharka, 2010) Outcomes are highest for recipients of renal and liver allografts, with survival rates for children reported at 89% and 80% respectively (Fernandez et al, 2009;McDonald et al, 2008), but significantly lower for other types of transplant, 67% at five years in heart transplant recipients, 54% and 42% at 3 and 5 years respectively in lung transplant recipients. Webber et al, 2006) Further, the overall survival according to stage is 80% for stages I/II, 61% for stage III, 20% for CNS involvement and less than 20% for BM involvement.…”

Section: Prognosismentioning

confidence: 99%