Post-Transplant Flow Cytometry Crossmatch and Acute Rejection in Renal Transplantation

O’Malley, Kiaran; Cook, Daniel; Roeske, L; McCarthy, James; Klingman, L.; Sano, Yuichi; Kapoor, Aanchal; Hobart, Michael G.; Flechner, S.; Modlin, Charles S.; Goldfarb, David A.; Dennis, Vincent W.; Novick, A C

doi:10.1097/00007890-199806270-00474

Cited by 2 publications

(4 citation statements)

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“…In our study, the number of acute rejections was higher among the converters, than among the nonconverters, which is consistent with earlier reports [3, 5, 121. The distribution of rejection episodes according to the severity of rejection was different in the two groups, having the same association of severe rejections and crossmatch conversion than in O'Malley et al [16]. Thus it is not surprising that the l-year graft survival of the converters was significantly lower and the mean serum creatinine concentration at 1 year after transplantation higher than in the nonconverters.…”

Section: Discussionmentioning

confidence: 70%

“…In the present study of 892 transplantations of cadaveric renal allografts, the complement-dependent cytotoxic T cell crossmatch test converted to positive in 8.5 % when measured on day 14 after transplantation. There are reports on crossmatch conversion after transplantation demonstrating the correlation with acute rejection and prognosis [3,5,7,12,16]. However, no data are available on the natural post-transplant course of the crossmatch test between the kidney donor and recipient, and the possible conversion of the test in rejection-free patients.…”

Section: Discussionmentioning

confidence: 99%

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The clinical significance of conversion of complement-dependent cytotoxic T cell crossmatch test after renal transplantation

Kyllönen¹,

Salmela²,

Koskimies³

1999

Transplant International

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The purpose of this study was to investigate the clinical relevance of conversion of post-transplant T cell crossmatch between kidney donor and recipient. This study comprises 892 cadaveric renal transplantations performed on 874 adult patients between August 1991 and December 1997. Recipient selection was based on a negative complement-dependent cytotoxic T cell crossmatch test with current (< or = 2 months old) serum. For this study, on day 0 and day 14 after transplantation, serum samples were collected for later crossmatching. On day 14 after transplantation, the crossmatch had converted to positive in 76 transplantations (8.5%). Acute rejection occurred in 50% of the converters and 22% of the non-converters (P < 0.005), and graft survival was significantly poorer (P < 0.025), being 85 vs 94% at 1 and 68 vs 83% at 5 years, respectively. In patients with delayed graft function, 1-year graft survival was 77% in the converters and 91% in the non-converters (P < 0.05). Conversion of T cell crossmatch, especially in connection with delayed graft function, identifies a subgroup of patients at high risk of severe rejection and poor graft survival.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

The clinical significance of conversion of complement-dependent cytotoxic T cell crossmatch test after renal transplantation

Kyllönen¹,

Salmela²,

Koskimies³

1999

Transplant International

View full text Add to dashboard Cite

show abstract

“…The distribution of rejection episodes according to the severity of rejection was different in the two groups, having the same association of severe rejections and crossmatch conversion than in O'Malley et al [16]. Thus it is not surprising that the l-year graft survival of the converters was significantly lower and the mean serum creatinine concentration at 1 year after transplantation higher than in the nonconverters.…”

Section: Discussionmentioning

confidence: 70%

“…There are reports on crossmatch conversion after transplantation demonstrating the correlation with acute rejection and prognosis [3,5,7,12,16]. However, no data are available on the natural post-transplant course of the crossmatch test between the kidney donor and recipient, and the possible conversion of the test in rejection-free patients.…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of conversion of complement-dependent cytotoxic T cell crossmatch test after renal transplantation

Kyllönen¹,

Salmela²,

Koskimies

1999

Transplant Int

View full text Add to dashboard Cite

The purpose of this study was to investigate the clinical relevance of conversion of post-transplant T cell crossmatch between kidney donor and recipient. This study comprises 892 cadaveric renal transplantations performed on 874 adult patients between August 1991 and December 1997. Recipient selection was based on a negative complement-dependent cytotoxic T cell crossmatch test with current ( 5 2 months old) serum. For this study, on day 0 and day 14 after transplantation, serum samples were collected for later crossmatching. On day 14 after transplantation, the crossmatch had converted to positive in 76 transplantations (8.5 Yo).Acute rejection occurred in 50 YO of the converters and 22 % of the nonconverters ( P < 0.005), and graft survival was significantly poorer ( P < 0.025), being 85 vs 94 YO at 1 and 68 vs 83 YO at 5 years, respectively. In patients with delayed graft function, l-year graft survival was 77 Yo in the converters and 91 YO in the non-converters ( P < 0.05). Conversion of T cell crossmatch, especially in connection with delayed graft function, identifies a subgroup of patients at high risk of severe rejection and poor graft survival.

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Post-Transplant Flow Cytometry Crossmatch and Acute Rejection in Renal Transplantation

Cited by 2 publications

References 0 publications

The clinical significance of conversion of complement-dependent cytotoxic T cell crossmatch test after renal transplantation

The clinical significance of conversion of complement-dependent cytotoxic T cell crossmatch test after renal transplantation

The clinical significance of conversion of complement-dependent cytotoxic T cell crossmatch test after renal transplantation

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