Post-translationally modified frog skin-derived antimicrobial peptides are effective against Aeromonas sobria

Evaluación de la capacidad de inhibición de hemólisis oxidativa y actividad antimicrobiana de fracciones peptídicas obtenidas de la hidrólisis de proteínas de huevo, leche y soya usando proteasas extraídas de Bromelia pinguin y Bromelia karatas

“…Aunque para la mayoría de los AMPs se describen procesos de permeabilización de la membrana, también pueden actuar utilizando otros mecanismos. Después de entrar en las células patógenas, estos AMPs alcanzan moléculas intracelulares, lo que lleva a la inhibición de la síntesis de la pared celular (Brötz, Bierbaum, Leopold, Reynolds & Sahl, 1998), la inactivación de enzimas (Kavanagh & Dowd, 2004) o interferencia en la síntesis de DNA, RNA y síntesis de proteínas (Vineethkumar, Asha, Shyla & George, 2017;Zhang et al, 2017).…”

Biological Properties, Current Applications and Potential Therapeautic Applications of Brevinin Peptide Superfamily

“…Exploiting this post-translational modification, the positive charge of the peptides increased and intensified the electrostatic interaction of peptides with the anionic membrane of bacteria. Besides, they revealed that the 3D-structure of these peptides was stabilized by internal disulfide bridge (Tv et al 2017). Also, another study reoprted the synthesis of 17 analogs of B1CTcu5 peptide by C-and N-terminal amino acid substitution or deletion and concluded that both regions are crucial for peptide function.…”

A Review on Futuristic Scope of Agents Related to Amphibian’s Skin and Plants-based Sources in Type 2 Antidiabetic Therapies

“…There have been number of proofs suggesting peptides isolated from frog skin showing diverse therapeutic abilities such as cytolytic activities against variety of bacteria and fungi, as to their designated activity to function as host defense peptides against pathogenic microbes. [60][61][62][63] Moreover, evidences propose that the isolated peptides also holds potential to be an vital anticancer/antitumor, [64][65][66][67] antiviral, [68][69][70] immunomodulatory, [71,72] agents etc. [10] Similarly, regarding effective antidiabetic activities, peptide isolated from Pipdae family frogs hold immense ability to be developed into as conventional diabetic therapy.…”