2010
DOI: 10.1007/978-1-4419-7002-2_13
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Post-Translational Modification of Cellular Proteins by Ubiquitin and Ubiquitin-Like Molecules: Role in Cellular Senescence and Aging

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Cited by 31 publications
(22 citation statements)
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“…Proteasome activity was found to be decreased in cellular senescence and organismal aging 7,8,9,10 . In the field of aging research, the focus is mainly on the removal of oxidized proteins where the proteasome plays a key role, and there is no conclusive evidence that protein ubiquitylation precedes degradation in this case 2 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Proteasome activity was found to be decreased in cellular senescence and organismal aging 7,8,9,10 . In the field of aging research, the focus is mainly on the removal of oxidized proteins where the proteasome plays a key role, and there is no conclusive evidence that protein ubiquitylation precedes degradation in this case 2 .…”
Section: Discussionmentioning
confidence: 99%
“…The dysfunction of the ubiquitin-proteasome system has been related to the development of tumors and neurodegenerative diseases 4,6 . Additionally, a decrease in proteasome activity was found as a feature of cellular senescence and organismal aging 7,8,9,10 . Here, we present a method to measure ubiquitin-proteasome activity in living cells using a GFP-dgn fusion protein.…”
mentioning
confidence: 99%
“…The role of deubiquitinases in aging of higher organisms remains unknown. In senescent cells, the levels of many ubiquitylated and sumoylated proteins are upregulated including telomerase, p53, histone H2A and PCNA resulting in proteasomal degradation (Grillari et al, 2010). Ubiquitylation of DAF-16 (discussed later), an important longevity protein causes shorter lifespan in worms (Li et al, 2007).…”
Section: Evidence For Epigenetic Changes In Agingmentioning
confidence: 99%
“…Conversely, overexpression of SNEV provokes extension of the replicative lifespan in these cells. In addition to being involved in spliceosome assembly and stabilization, SNEV regulates proteasome function due to its U3-ligase activity, and is involved in DNA repair (Grillari et al, 2010). Furthermore, the haploinsufficiency of SNEV has been demonstrated using a heterozygous mouse model, which showed that the proliferative and repopulating capacity of hematopoietic stem cells from these mice was clearly compromised (Schraml et al, 2008).…”
Section: Splicing Factors Involved In Endothelial Senescencementioning
confidence: 99%