Post-transfusion fulminant hepatitis B after screening for hepatitis B virus core antibody

Yoshiba, Makoto; Sekiyama, Kazuhiko; Sugata, Fumio; Kawamoto, Y.; Muraoka, Haruo; Aoyama, Mikio

doi:10.1016/0140-6736(92)90067-d

Cited by 18 publications

(8 citation statements)

References 2 publications

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“…In OBI patients, the aforementioned tests have low efficacy because of undetectable HBsAg due to possible viral mutations or imperfect immune responses of the host. Some OBI cases stay uncovered by these assays and have the potential ability to spread viral infection and be a source of HBV transmission through transfusion (25). One of the suggestions of this study is to follow up the people who received donated blood from OBI patients to observe the effect of this donation on their health and evaluate the reactions of their immune system too.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B Viral DNA Among HBs Antigen Negative Healthy Blood Donors

et al. 2013

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BackgroundPresence of occult hepatitis B infection (OBI) renders HBs antigen (HBsAg) undetectable by ELISA. Therefore it is valuable to evaluate the frequency of OBI among healthy blood donors to improve and perhaps change the strategies of blood screening to reduce the risk of HBV transmission.ObjectivesThe aim of this study was to determine the presence of HBcAb and HBV DNA among Iranian HBsAg negative healthy blood donors who donated their blood to the Tehran Blood Transfusion Center during 2011.Patients and Methods1000 serum specimens negative for HBsAg, HCV antibody and HIV antibody were collected from healthy blood donors and tested for HBcAb. Presence of hepatitis B viral DNA was checked in HBcAb positive samples by nested PCR with two sets of primers to amplify part of HBV S gene.ResultsThere were 64 women and 936 men in the population under study. The mean ± SD age of the donors was 38 ± 11 years. 80 out of 1000 samples (8%) were found to be positive for HBcAb. HBV DNA was detected in 50% of HBcAb positive specimens. The mean ± SD age of donors without HBV DNA was 37.7 ± 10.5 years and for donors with HBV DNA was 40.9 ± 11.2 years (P = 0.05).ConclusionsOBI was prevalent among 50% of HBcAb positive healthy blood donors. The frequency of positive HBcAb among healthy HBsAg negative blood donors was comparable to previous studies reported from Iran. On the other hand, the frequency of HBV DNA in HBsAg negative blood donors was higher than previous reports.

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Section: Discussionmentioning

confidence: 99%

Hepatitis B Viral DNA Among HBs Antigen Negative Healthy Blood Donors

et al. 2013

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“…Carriers of occult infection may be a source of HBV transmission in the case of blood transfusion [27,90,91] with the consequent development of a typical type B hepatitis in the recipients. This possible occurrence was first reported in the late 1970s [26,92] and experimentally confirmed in chimpanzees some years later [93].…”

Section: Transmission Of Occult Hbv Infectionmentioning

confidence: 99%

Occult hepatitis B virus infection

Raimondo¹,

Pollicino²,

Cacciola³

et al. 2007

Journal of Hepatology

442

295

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“…In Japan, Yoshiba and coworkers 126 described a case of fulminant hepatitis B with recovery in a recipient of a unit of blood from a donor who was diagnosed with acute hepatitis B 2 months after he donated blood. Presumably, this unit of blood was collected during the seronegative window period of the disease.…”

Section: Occult Hepatitis Bmentioning

confidence: 99%