Post-transcriptional silencing of myostatin-1 in the spotted rose snapper (Lutjanus guttatus) promotes muscle hypertrophy

Torres-Velarde, Julia Maria; Llera-Herrera, Raúl; Ibarra‐Castro, Leonardo; García-Gasca, Teresa; García‐Gasca, Alejandra

doi:10.1007/s11033-019-05147-1

Cited by 6 publications

(2 citation statements)

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“…Myostatin, a transforming growth factor β (TGF-β) superfamily member, is well-characterized as an inhibitor of proliferation and differentiation in mammalian muscle. Loss of function of myostatin also increases muscle growth in many fish species (Lee et al 2009 ; Chisada et al 2011 ; Gao et al 2016 ; Torres-Velarde et al 2020 ), though not in all fish species tested (Terova et al 2013 ). Evidence from mammals (Morissette et al 2009 ) and fish (Liu et al 2020 ) indicates that myostatin inhibits Akt, a positive regulator of muscle hypertrophy.…”

Section: Cell Sources For Csmentioning

confidence: 99%

Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology

Bomkamp¹,

Musgrove

Marques

et al. 2022

Mar Biotechnol

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Cultivated meat, also known as cultured or cell-based meat, is meat produced directly from cultured animal cells rather than from a whole animal. Cultivated meat and seafood have been proposed as a means of mitigating the substantial harms associated with current production methods, including damage to the environment, antibiotic resistance, food security challenges, poor animal welfare, and—in the case of seafood—overfishing and ecological damage associated with fishing and aquaculture. Because biomedical tissue engineering research, from which cultivated meat draws a great deal of inspiration, has thus far been conducted almost exclusively in mammals, cultivated seafood suffers from a lack of established protocols for producing complex tissues in vitro. At the same time, fish such as the zebrafish Danio rerio have been widely used as model organisms in developmental biology. Therefore, many of the mechanisms and signaling pathways involved in the formation of muscle, fat, and other relevant tissue are relatively well understood for this species. The same processes are understood to a lesser degree in aquatic invertebrates. This review discusses the differentiation and maturation of meat-relevant cell types in aquatic species and makes recommendations for future research aimed at recapitulating these processes to produce cultivated fish and shellfish.

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Section: Cell Sources For Csmentioning

confidence: 99%

Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology

Bomkamp¹,

Musgrove

Marques

et al. 2022

Mar Biotechnol

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show abstract

“…It is well known that myostatin modulates muscle homeostasis, and that myostatin is involved in myocyte differentiation and proliferation. A study using Lutjanus guttatus lacking myostatin resulted in muscle fiber hypertrophy, with myostatin and IGFBP5 downregulated in T3treated rats [33,34]. In addition, myostatin inhibition is used to treat oculopharyngeal muscular dystrophy; Dickson et al [35] reported that target treatment for myostatin improved the body and muscle masses in patients, and reduced the levels of muscle fibrosis markers.…”

Section: Characterization Of Eom-mpcs From Go Patientsmentioning

confidence: 99%

Isolation and Characterization of Extraocular Muscle-Derived Muscle Progenitor Cells from Normal and Graves' Orbitopathy Patients

Park

Nepali

Lew

2020

Stem Cells and Development

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Mesenchymal stem cells (MSCs) are useful for various purposes, including tissue engineering, regeneration, and gene therapy. MSCs isolated from extraocular muscles (EOMs) can be easily expanded in vitro, and can undergo multilineage differentiations involving adipogenesis, chondrogenesis, osteogenesis, and even neuronal or myogenic differentiation. This study aimed to isolate, characterize, and compare extraocular muscle-derived muscle progenitor cells (EOM-MPCs) from normal subjects and patients with Graves' orbitopathy (GO). EOM was obtained during strabismus surgery. Flow cytometry was conducted to identify CD surface antigens such as CD34, CD45, CD44, CD59, CD73, and CD90. We quantitated various cytokines secreted from MSCs, including interleukin (IL)-1a, IL-2, IL-6, IL-8, IL-10, IL-12, IL17A, tumor necrosis factor (TNF)-a, and interferon (IFN)-g, using a multi-analysis enzyme-linked immunosorbent assay array kit. We performed Oil Red O staining for adipogenesis, Alzarin Red staining for osteogenesis, Alcian blue staining for chondrogenesis, and polymerase chain reaction to measure messenger RNA expression during myogenesis. Our results show that EOM-MPCs from normal subjects and GO patients had similar levels of surface antigen expression and cytokine secretion. There was also no significant difference in the multilineage differentiation of adipocytes, chondrocytes, osteocytes, and myoblasts from EOM-MPCs taken from normal subjects and GO patients. However, hyaluronic acid synthetase 2 expression was higher after induction with tafluprost in EOM-MPCs from GO patients when compared with normal subjects. Together, these results show that EOM-MPCs derived from normal subjects are a good source for stem cell-based therapy for various disorders.

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Transgenic red carp (Cyprinus carpio) with LcMSTN1 propeptide: Enhanced growth and unchanged muscle fat content

et al. 2021

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Post-transcriptional silencing of myostatin-1 in the spotted rose snapper (Lutjanus guttatus) promotes muscle hypertrophy

Cited by 6 publications

References 50 publications

Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology

Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology

Isolation and Characterization of Extraocular Muscle-Derived Muscle Progenitor Cells from Normal and Graves' Orbitopathy Patients

Transgenic red carp (Cyprinus carpio) with LcMSTN1 propeptide: Enhanced growth and unchanged muscle fat content

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