Transgenic red carp (Cyprinus carpio) with LcMSTN1 propeptide: Enhanced growth and unchanged muscle fat content

Zhang, Yu; Tang, Ze-Yuan; Liu, Zhifei; Shen, Jingyi; Feng, Huijie; Xue, Liyan

doi:10.1016/j.aquaculture.2021.736795

Cited by 3 publications

(1 citation statement)

References 48 publications

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“…These traits can be achieved, e.g., by disrupting the mstnba gene that encodes myostatin using CRISPR/Cas. Myostatin is a growth factor that inhibits muscle cell growth; hence, its inhibition leads to increased muscle fiber number and size (muscle growth), body weight and fish length [ 114 , 120 ]. Genome editing was also used to improve growth and feed conversion efficiency in gibel carp by targeting a lipid kinase gene [ 116 ].…”

Section: Monitoring Requirements Of Novel Gmo Applicationsmentioning

confidence: 99%

Challenges for the Post-Market Environmental Monitoring in the European Union Imposed by Novel Applications of Genetically Modified and Genome-Edited Organisms

Dolezel,

Lang,

Greiter

et al. 2024

BioTech

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Information on the state of the environment is important to achieve the objectives of the European Green Deal, including the EU’s Biodiversity Strategy for 2030. The existing regulatory provisions for genetically modified organisms (GMOs) foresee an obligatory post-market environmental monitoring (PMEM) of potential adverse effects upon release into the environment. So far, GMO monitoring activities have focused on genetically modified crops. With the advent of new genomic techniques (NGT), novel GMO applications are being developed and may be released into a range of different, non-agricultural environments with potential implications for ecosystems and biodiversity. This challenges the current monitoring concepts and requires adaptation of existing monitoring programs to meet monitoring requirements. While the incorporation of existing biodiversity monitoring programs into GMO monitoring at the national level is important, additional monitoring activities will also be required. Using case examples, we highlight that monitoring requirements for novel GMO applications differ from those of GM crop plants previously authorized for commercial use in the European Union.

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Section: Monitoring Requirements Of Novel Gmo Applicationsmentioning

confidence: 99%

Challenges for the Post-Market Environmental Monitoring in the European Union Imposed by Novel Applications of Genetically Modified and Genome-Edited Organisms

Dolezel,

Lang,

Greiter

et al. 2024

BioTech

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Comparison of nutritional quality, flesh quality, muscle cellularity, and expression of muscle growth-related genes between wild and recirculating aquaculture system (RAS)-farmed black rockfish (Sebastes schlegelii)

et al. 2023

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Effects of Dietary Multi-Strain Probiotics on Growth Performance, Antioxidant Status, Immune Response, and Intestinal Microbiota of Hybrid Groupers (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂)

Xie,

Chen,

Feng

et al. 2024

Microorganisms

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This study aims to examine the effects of the mixture of Bacillus cereus G1–11 and Exiguobacterium acetylicum G1–33, isolated from the gut of hybrid groupers (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂), on the host. The hybrid groupers were divided into a control (C, without any probiotics), B. cereus (BC, 1010 cfu/g), E. acetylicum (EA, 108 cfu/g), compound (mix, a 1:1 mixture of B. cereus and E. acetylicum), and positive reference group (P, Lactobacillus acidophilus, 5 × 108 cfu/L). Each group had four replicates, with 30 fish per replicate (53.30 ± 0.50 g), and were fed for 60 days. The results showed that adding probiotics to the feed significantly improved the weight gain, weight growth rate, specific growth rate, and digestive enzyme activities of hybrid groupers compared to the C group. The compound group was the most significant. In addition, composite probiotics added to feed significantly upregulated the expression levels of several growth-related genes in the liver and muscles. The activities of alkaline phosphatase, catalase, glutathione peroxidase, glutathione transferase, lysozyme, and total antioxidant capacity in the serum and liver were significantly influenced through mixed probiotic feeding. Moreover, the expression levels of several immune-related genes in the liver, spleen, and head kidney were significantly enhanced by adding single and mixed probiotics to feed, with the synergy of mixed probiotics being the best. An analysis of the gut microbiota showed that adding composite bacteria enhanced the richness and diversity of the gut microbiota, significantly increasing the relative abundance of potential probiotics (Cetobacterium and Microbacterium) while decreasing the presence of potential pathogens (Mycoplasma). Overall, our findings highlighted the efficacy of mixed probiotics (B. cereus and E. acetylicum) in enhancing growth performance, nutritional value of hybrid grouper feed, antioxidant capacity, immune response, and intestinal health, in finding the best combination of functional feed additives.

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Transgenic red carp (Cyprinus carpio) with LcMSTN1 propeptide: Enhanced growth and unchanged muscle fat content

Cited by 3 publications

References 48 publications

Challenges for the Post-Market Environmental Monitoring in the European Union Imposed by Novel Applications of Genetically Modified and Genome-Edited Organisms

Challenges for the Post-Market Environmental Monitoring in the European Union Imposed by Novel Applications of Genetically Modified and Genome-Edited Organisms

Comparison of nutritional quality, flesh quality, muscle cellularity, and expression of muscle growth-related genes between wild and recirculating aquaculture system (RAS)-farmed black rockfish (Sebastes schlegelii)

Effects of Dietary Multi-Strain Probiotics on Growth Performance, Antioxidant Status, Immune Response, and Intestinal Microbiota of Hybrid Groupers (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂)

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