Post-stroke apathy

Petrova, Elizaveta A.; Ponevejsky, Ekaterina V.; Savina, Maria A.; Koltsova, E.A.

doi:10.26442/20751753.2020.9.200274

Cited by 2 publications

(1 citation statement)

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“…PSA is generally defined as a disorder of diminished motivation caused by a stroke ( 31 ). The symptoms of PSA are loss of interest, diminished emotional response, and loss of initiative ( 33 ), which are quite similar to those of PSD. In addition, based on physiology, both PSD and PSA are related to fronto-striatal circuit dysfunction and small vessel ischemia ( 34 , 35 ).…”

Section: Diagnosis Of Psdmentioning

confidence: 96%

The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression

Zheng-ming

et al. 2022

Front. Psychiatry

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Post-stroke depression (PSD) is the most common and serious sequelae of stroke. Approximately 33% of stroke survivors were affected by PSD. However, many issues (e.g., incidence, diagnostic marker, and risk factor) related to PSD remained unclear. The “monoamine hypothesis” is a significant hypothesis for depression, which suggests that three monoamines play a key role in depression. Therefore, most current antidepressants are developed to modulate the monoamines on PSD treatment, and these antidepressants have good effects on patients with PSD. However, the potential mechanisms of three monoamines in PSD are still unclear. Previously, we proposed “three primary emotions,” which suggested a new model of basic emotions based on the three monoamines. It may provide a new way for PSD treatment. In addition, recent studies have found that monoamine-related emotional intervention also showed potential effects in the treatment and prevention of PSD. This study discusses these issues and attempts to provide a prospect for future research on PSD.

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Section: Diagnosis Of Psdmentioning

confidence: 96%

The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression

Zheng-ming

et al. 2022

Front. Psychiatry

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Poststroke Asthenic Disorder

Kutlubaev,

Akhmetova

2024

Annals of Clinical and Experimental Neurology

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Asthenic disorders are seen in approximately half of poststroke patients. The mechanisms underlying poststroke asthenia (PSA) are related to brain connectome damage, as well as neuroinflammatory and neuroendocrine mechanisms. PSA is associated with a lack of energy, lassitude, and fatigue that do not improve after rest or sleep; it is differentiated from depression, apathy, and daytime drowsiness. Risk factors for PSA include female gender, anxiety and depressive disorders, severe neurological deficit, sleep disorders, diabetes etc. Treatment of PSA includes cognitive behavioral therapy graded physical activity, and pharmacotherapy.

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Post-stroke apathy

Cited by 2 publications

References 0 publications

The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression

The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression

Poststroke Asthenic Disorder

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