Post‐operative blood loss after transurethral prostatectomy is dependent on in situ fibrinolysis

Abstract

Objective To evaluate whether post-operative blood lossResults The post-operative blood loss correlated significantly with the per-operative loss (P=0.047) and the in patients with benign prostatic hyperplasia, undergoing transurethral resection of the prostate (TURP), weight of resected tissue (P=0.029). There was a highly significant correlation between the area under depends on in situ fibrinolysis in urine, and to determine the relative contributions of the urokinase and the curve of FbDP in the urine and the post-operative blood loss (P<0.005), while there was no significant tissue-type plasminogen activator systems. Patients and methods TURP was performed in 24 men positive correlation between the PA concentration or activity in the urine and post-operative blood loss. (median age 68.5 years, range 52-78) and the weight of resected tissue, the operative and post-operativeThere was a significant correlation between the urinary t-PA activity and the amount of FbDP in the blood loss determined. The concentrations of the urokinase-(u-PA) and tissue-type plasminogen actiurine (P=0.047), and a significant correlation between the weight of resected tissue and the amount vator (t-PA)-related fibrinolysis in their urine was followed using sensitive and specific assays, and the of FbDP in the urine (P=0.014). Conclusion The post-operative blood loss after TURP is changes related to post-operative blood loss. Measurements of the urinary concentrations of free significantly related to an increase of the urinary fibrinolytic activity and the enhanced fibrinolytic t-PA activity, t-PA antigen, free u-PA activity, u-PA antigen and fibrin degradation products (FbDP) were activity is probably caused by t-PA. Keywords In situ fibrinolysis, blood loss, transurethral determined and the area under the curve for each of these quantities correlated with the post-operative prostatic resection blood loss.antifibrinolytic drugs on post-operative blood loss [6][7][8][9].

Epidemiology of Human Papillomavirus Infection

“…Although the most likely mechanism for bleeding is the effect on platelet function it is noteworthy that ASA not only acetylates cyclooxygenase but also fibrinogen (14), and this may lead to alteration in the fibrin structure making it more susceptible to lysis by plasminogen activators (15). If this is the case, it is in accordance with our previous study where we demonstrated that the postoperative blood loss after TURP was dependent on in situ fibrinolysis (16).…”

Painless urethral bleeding: an unusual presentation of Von Willebrand disease

“…We believe the prolonged course of urethral bleeding was likely due to a deficiency of vWF and the presence of naturally occurring fibrinolytic substances in urine [16,17]. One occurred following Foley catheterization and the other was spontaneous.…”

The current status of bridging anticoagulation

“…the liver, spleen and kidney Colonic polyp resection, where bleeding may occur at the transected stalk (Sorbi et al , ) Bowel resection in which bleeding may occur at the bowel anastomosis site Cardiac, intracranial or spinal surgery, where a bleed can have significant consequences (Lazio & Simard, ; Jones et al , ; Mangano, ) Pacemaker or implantable cardioverter – defibrillator device implantation, where the risk of haematoma development is significant (Jamula et al , ; Robinson et al , ; Tischenko et al , ; Chow et al , ). However, recent results from the BRUISE CONTROL study demonstrated that continuing oral VKA therapy is superior to using UFH or LMWH, in the context of pocket haematoma formation (Birnie et al , ) Procedures associated with the urogenital tract, where endogenous urokinase is thought to promote bleeding (Watson et al , ; Nielsen et al , ; Ihezue et al , ). Such procedures include transurethral prostate resection, bladder resection or tumour ablation, nephrectomy and kidney biopsy…”