Post-operative analgesia following TPLO surgery: A comparison between cimicoxib and tramadol

Piras, Lisa Adele; Mancusi, Davide; Olimpo, Matteo; Gastaldi, Laura; Rosso, Valeria; Panero, Elisa; Staffieri, Francesco; Peirone, Bruno

doi:10.1016/j.rvsc.2021.03.010

Cited by 8 publications

(9 citation statements)

References 54 publications

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“…Several anatomic locations to obtain measurements on the pelvic and thoracic limbs have been described. The most commonly used region was the thigh at a single level [ 4 – 12 , 18 – 23 , 26 – 33 , 35 , 36 , 38 – 42 , 44 – 54 , 58 – 63 ] but six of these studies [ 9 , 22 , 26 , 27 , 29 , 50 ] also measured the thigh at a second level. Brachium [ 24 , 25 , 43 , 52 , 55 , 57 ], stifle [ 20 , 22 , 34 , 56 , 63 ], crus [ 4 , 39 , 44 , 52 ], and antebrachium [ 24 , 37 , 43 , 52 ] circumference at a single level were also described.…”

Section: Resultsmentioning

confidence: 99%

“…• Mid-point of the thigh length [ 5 , 6 , 8 , 11 , 12 , 20 , 31 , 36 , 38 , 44 , 47 ], [ 50 ] a , [ 51 , 52 , 54 ]…”

Section: Resultsmentioning

confidence: 99%

“…Both limbs had the same condition (e.g., monitoring muscle mass in patients with hip osteoarthritis) in nine studies, and limbs had various conditions after unilateral procedures (e.g., monitoring muscle mass after fracture repair or TPLO of one side) in the other 40 studies. Those 40 studies used several different methods of data collection, which included presentation of absolute differences (cm, mm) [ 6 , 8 , 11 , 18 , 22 , 27 , 30 , 31 , 34 , 38 , 40 , 41 , 46 , 47 , 55 ] and percentage differences [ 4 , 7 , 20 , 21 , 23 , 53 ] between affected limb and unaffected contralateral limb, absolute differences (cm, mm) [ 5 , 9 , 56 ] and percentage differences [ 10 , 19 , 25 , 35 , 45 , 48 , 54 ] between pre-treated and post-treated same single limb, absolute circumference values (cm, mm) of bilateral limbs [ 39 , 43 ], and normalized limb circumference data by dividing it by the body weight in kilograms [ 24 ]. The remaining studies [ 12 , 26 , 28 , 29 , 42 , 63 ] did not clearly state how the comparisons between limbs were made.…”

Section: Resultsmentioning

confidence: 99%

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Appendicular skeletal muscle mass assessment in dogs: a scoping literature review

et al. 2022

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Background Monitoring changes in appendicular skeletal muscle mass is frequently used as a surrogate marker for limb function. The primary objective of this study was to review scientific information related to the assessment of appendicular skeletal muscle mass in dogs. The secondary objective was to develop practical recommendations for serial evaluation of muscle mass. Methods A scoping review was conducted with a systematic search of PubMed, Web of Science, CAB abstract, and Cochrane from inception to June 2021. The following modalities were included in the search: limb circumference, diagnostic ultrasound, computed tomography, magnetic resonance imaging, and dual-energy x-ray absorptiometry. Results A total of 62 articles that measured appendicular skeletal muscle mass in dogs were identified. Limb circumference (55 articles) was the most commonly used modality. Its reliability was investigated in five studies. Several factors, including measuring tape type, body position, joint angles, and the presence of hair coat, were reported as variables that can affect measurements. Diagnostic ultrasound (five articles) was validated in three articles, but there is scarce information about observer reliability and variables affecting the measurement. Computed tomography (four articles) and magnetic resonance imaging (one article) have been used to validate other modalities at a single time point rather than as a clinical tool for serial muscle mass monitoring. Dual-energy x-ray absorptiometry (two articles) has been used to quantify specific skeletal muscle mass but was mainly used to evaluate body composition in dogs. Conclusion Limb circumference and ultrasound are likely the main modalities that will continue to be used for serial muscle mass measurement in the clinical setting unless a new technology is developed. The reliability of limb circumference is questionable. Several key factors, including measuring tape type, body position, joint angles, and coat clipping, need to be controlled to improve the reliability of limb circumference measurements. Ultrasound may provide a reasonable alternative, but further studies are required to evaluate the reliability of this modality and identify factors that influence ultrasound measurements.

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Section: Resultsmentioning

confidence: 99%

“…• Mid-point of the thigh length [ 5 , 6 , 8 , 11 , 12 , 20 , 31 , 36 , 38 , 44 , 47 ], [ 50 ] a , [ 51 , 52 , 54 ]…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Appendicular skeletal muscle mass assessment in dogs: a scoping literature review

et al. 2022

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“…Conversely, Benitez et al [ 69 ] achieved similar analgesia to a hydrocodone–acetaminophen protocol following oral administration of tramadol (5–7 mg/kg/8 h) after tibial plateau leveling osteotomy. Piras et al [ 70 ] determined that cimicoxib and tramadol have similar analgesic potency for long-term analgesia for the same procedure. However, treatment with a selective COX-2 inhibitor conferred superior functional improvements.…”

Section: Therapeutic Efficacy Of Tramadol In Dogsmentioning

confidence: 99%

Clinical pharmacology of tramadol and tapentadol, and their therapeutic efficacy in different models of acute and chronic pain in dogs and cats

Domínguez-Oliva¹,

Casas-Alvarado²,

Miranda-Cortés³

et al. 2021

J Adv Vet Anim Res

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Opioids are considered the gold standard to manage acute or chronic or mild to severe pain. Tramadol is a widely prescribed analgesic drug for dogs and cats; it has a synthetic partial agonism on μ-opioid receptors and inhibits the reuptake of norepinephrine and serotonin. However, the biotransformation and resultant metabolites differ between species and depend on cytochrome P450 interactions. Dogs mainly produce the inactive N-desmethyl tramadol metabolite, whereas cats exhibit an improved antinociceptive effect owing to rapid active O-desmethyltramadol metabolite production and a longer elimination half-life. Tapentadol, a novel opioid with dual action on μ-receptors and noradrenaline reuptake inhibitory activity, is a promising option in dogs, as it is less reliant on metabolic activation and is unaffected by cytochrome polymorphisms. Although scientific evidence on the analgesic activity of tapentadol in both species remains limited, experimental studies indicate potential benefits in animals. This review summarizes and compares the pharmacology, pharmacokinetics, and therapeutic efficacy of tramadol and tapentadol in dogs and cats with different pain conditions. According to the available data, tramadol seems a more suitable therapeutic option for cats and should preferably be used as a component of multimodal analgesia in both species, particularly dogs. Tapentadol might possess a superior analgesic profile in small animals, but additional studies are required to comprehensively evaluate the activity of this opioid to manage pain in dogs and cats.

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“…Goniometry has been used in canine orthopaedics [ 20 ] to assess the treatment efficacy of diseases involving shoulders [ 21 ], elbows [ 19 , 22 , 23 ], stifles [ 19 , 24 , 25 , 26 , 27 , 28 , 29 ] and hip joints [ 30 , 31 ]. The most common injury involving the canine stifle joint is cranial cruciate ligament (CCL) rupture [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Cranial Cruciate Ligament Rupture on Range of Motion in Dogs

Pinna

Lanzi

Tassani

2021

Veterinary Sciences

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Range of motion (ROM) is a measure often reported as an indicator of joint functionality. Both the angle of extension and that of flexion were measured in 234 stifle joints of dogs with cranial cruciate ligament (CCL) rupture. The aims of this study were to investigate the correlation between CCL rupture and alterations in the range of stifle joint motion and to determine whether there was a prevalence modification of one of the two angles. All the extension and flexion angles were obtained from clinical records and were analysed in various combinations. A significant relationship was found between normal angles and abnormal angles; concerning the reduction in the ROM, a significant prevalence in the alteration extension angle was found. Of the 234 stifles, 33 (13.7%) were normal in both angles. These results could offer important insights regarding the influence of CCL rupture on compromising the ROM. This awareness could be a baseline for understanding the ability of surgical treatment to restore one angle rather than another angle, to address the choice of treatment and to help physiotherapists in their rehabilitation program.

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Post-operative analgesia following TPLO surgery: A comparison between cimicoxib and tramadol

Cited by 8 publications

References 54 publications

Appendicular skeletal muscle mass assessment in dogs: a scoping literature review

Appendicular skeletal muscle mass assessment in dogs: a scoping literature review

Clinical pharmacology of tramadol and tapentadol, and their therapeutic efficacy in different models of acute and chronic pain in dogs and cats

The Effect of Cranial Cruciate Ligament Rupture on Range of Motion in Dogs

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