Post-mastectomy radiotherapy in Denmark: From 2D to 3D treatment planning guidelines of The Danish Breast Cancer Cooperative Group

Improvement of prognosis in breast cancer in Denmark 1977–2006, based on the nationwide reporting to the DBCG Registry

“…Postoperative radiotherapy was offered to all patients following BCS (target residual breast'chest wall, 48 Gy, 5 fr/w'boost, 10 Gy, 5 fr/w, 2 Gy/fr), and to patients with positive nodes or invasion through the deep fascia or into the skin (target chest wall'regional nodes, 48 Gy, 5 fr/w) with some modifications during the period as described in details elsewhere [3,9].…”

Postmastectomy radiotherapy with integrated scar boost using helical tomotherapy

“…[17][18][19][20][21][22][23][24] Recent studies have shown that tomotherapy may serve as a feasible alternative to treat postlumpectomy or postmastectomy patients who have been treated conventionally with electrons, static photon beams, or a combination of the two. 18,[25][26][27][28][29][30][31][32] The tumor control probability and the normal tissue complication probability with tomotherapy are comparable with mixed-beam plans with greater dose homogeneity (p Ͻ 0.001), which may translate into improved cosmetic outcomes. 27 Moreover, tomotherapy is proved to be feasible for treating simultaneous integrated boost (SIB) for breast-conserving treatment with adequate tumor coverage and significant normal tissue sparing.…”

“…It is evident from the studies that the ipsilateral lung normally receives a maximum of 105% of the prescribed dose with these conventional irradiation techniques. 25,26 With the helical tomotherapy system, the intensity of the 6-MV fan beam can be modulated by a row of 64 binary leaves projected to the isocenter. Also, 51 projections per gantry rotation assist the individual modulation patterns, which are further optimized by the tomotherapy planning process.…”

Assessment of brain dose distribution for ARC and conformal radiation therapy (CRT): A comparison study

“…A 3D planning system can calculate the dose in each pixel of the organ outlined and sum these to produce a DVH. 3D treatment planning is, therefore, a powerful tool that can be used to compare treatment techniques for adequacy of target coverage and complication risk (Thomsen et al, 2008).…”