Post-Market Safety and Efficacy Surveillance of Herbal Medicinal Products from Users Perspective: A Qualitative Semi-Structured Interview Study in Kumasi, Ghana

Adusei-Mensah, Frank; Haaranen, Ari; Kauhanen, Jussi; Tikkanen-Kaukanen, Carina; Henneh, Isaac Tabiri; Ganu, Daniel; Ametsetor, Ebenezer Seklu Edem; Olaleye, Sunday Adewale; Ekor, Martins

doi:10.31531/2581-3080.1000136

Cited by 3 publications

(4 citation statements)

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“…In our recent survey, we observed that most of the subjects used herbal medicines solely or in combination with orthodox drug for various health needs including preventive, curative and chronic disease management. The study participants demonstrated high level of trust in herbal medicines and believed that herbal medicines are better curative agents than pharmaceutical medicine [8].…”

Section: Introductionmentioning

confidence: 99%

Sub-chronic toxicity evaluation of top three commercial herbal antimalarial preparations in the Kumasi metropolis, Ghana

et al. 2020

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Purpose: Safety data on commonly used herbal medicinal (HM) products (HMPs) and marketed in Ghana are scarce. We assessed the sub-chronic toxicity of three most-patronised commercial antimalarial HMPs in Kumasi, Ghana. Method: Top three HMPs (designated as herbal products ‘A’ (HPA), ‘B’ (HPB) and ‘C’ (HPC)) were selected after a mini-survey and sub-chronic toxicity evaluation conducted in accordance with Organisation for Economic Co-operation and Development (OECD) 407 guidelines. Control rats received clean water while test groups received daily adult human dose (DAHD), 5× DAHD or 10× DAHD of either HPA, HPB or HPC for 30 days. Rats were killed on day 31 to obtain biochemical, haematology and histology samples for analysis. Data were analysed by one-way analysis of variance (ANOVA) and post hoc Tukey’s test. Results: The three HMPs produced alterations in liver morphology predominantly characterised by prominent foci of fatty change with scattered hepatocytes containing intracytoplasmic fat globules and congested central veins and sinusoids. The lungs showed alveolar with evidence of inflammation and foci of epithelial sloughing. Alveolar spaces were also obscured by debris and inflammatory cells. HPA and HPC produced scattered intensely congested heart vessels while HPB(10) produced haemorrhage and amorphous exudates within the heart. All HMPs produced neither treatment-related deaths nor significant change in haematological and biochemical parameters, except for HPA and HPB which decreased (P<0.05) aspartate aminotransferase (AST) and HPB, which elevated (P<0.05) fasting blood glucose (FBG). Conclusion: Data from the present study suggest the potential of the herbal products (HPs), HPA, HPB and HPC, to cause major organ-system dysfunction or damage. We advise cautious use of these products and recommend further safety evaluation in chronic toxicity models.

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Section: Introductionmentioning

confidence: 99%

Sub-chronic toxicity evaluation of top three commercial herbal antimalarial preparations in the Kumasi metropolis, Ghana

et al. 2020

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“…Ethnomedicinal plants have been used in folk medicine to treat various ailments. Their natural origin has fueled the erroneous assumption that they are very safe and devoid of possible serious adverse effects [ 10 , 27 ]. To guarantee their safety for human consumption and marketing, medicinal plant extracts and other potential drug molecules must undergo toxicological and pharmacological evaluations as required by regulatory agencies.…”

Section: Discussionmentioning

confidence: 99%

“…However, the use of these conventional drugs has been limited by their numerous side effects, which include dizziness, postural hypotension, headache, tachycardia, abnormal ejaculation, and somnolence, among others [ 9 ]. This has resulted in increased patronage of medicinal plant alternatives, which are considered to be generally safer, easily assessable, and affordable [ 10 ]. One of these plant alternatives is Croton membranaceus Mull.…”

Section: Introductionmentioning

confidence: 99%

Acute Oral Toxicological Profile of Croton membranaceus Mull. Arg. Aqueous Stem Extract, a Herbal Treatment for Benign Prostate Hyperplasia, in Male Sprague–Dawley Rats

Afriyie,

Ameyaw,

Henneh

et al. 2024

Journal of Toxicology

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Croton membranaceus Mull. Arg. is a traditional medicinal plant frequently employed in Ghana for the treatment of benign prostatic hyperplasia and prostate cancer. The objective of this study was to determine the acute oral toxicity of the aqueous stem extract of Croton membranaceus (CMASE) in male Sprague–Dawley (S-D) rats. The acute toxicity of CMASE was evaluated using S-D rats randomly divided into four groups of five animals each. Three groups (low dose, median dose, and high dose) of rats received single oral doses of CMASE (1000, 2500, and 5000 mg/kg body weight, respectively) using an oral gavage. The control group was given distilled water. After 14 days of daily observations, hematological, biochemical, and histopathological analyses were conducted on the rats. From the results obtained, doses of CMASE up to 5000 mg/kg did not cause death or induce any clinical indications of toxicity during the study period. Also, the mean body weight and the hematological indices assessed were not significantly affected by the various doses of CMASE compared to the control group. However, serum uric acid and creatinine levels decreased significantly (p<0.001) 14 days after the extract administration. Serum liver function enzyme levels, including alkaline phosphatase (ALP), alanine aminotransferases (ALT), and aspartate aminotransferases (AST), and serum proteins (total proteins and albumin) exhibited significant (p<0.001) non dose-dependent changes (increases and decreases) in treated groups compared to the controls. Other biochemical indices, however, did not differ significantly between the treated groups and the controls. The gross pathological and histological analysis of the heart, liver, and kidney tissues did not reveal any significant changes in histoarchitecture. The oral LD50 of CMASE in rats was greater than 5000 mg/kg, indicating that the extract was relatively safe. It must, however, be used with care as a substitute for the roots.

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“…The traditional herbal medicines reached a bit late to Europe from its Asian counterparts. In Europe it was first originated in Ancient Greece and was based on the accumulated knowledge of herbal medicines [4] from Babylon, Egypt, and Persia at around 5th century B.C. [5].…”

Section: Introductionmentioning

confidence: 99%

Phytonutrients and technological development in formulations

Khan

Islam

Alam

et al. 2023

Phytonutrients and Neurological Disorders

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Post-Market Safety and Efficacy Surveillance of Herbal Medicinal Products from Users Perspective: A Qualitative Semi-Structured Interview Study in Kumasi, Ghana

Cited by 3 publications

References 0 publications

Sub-chronic toxicity evaluation of top three commercial herbal antimalarial preparations in the Kumasi metropolis, Ghana

Sub-chronic toxicity evaluation of top three commercial herbal antimalarial preparations in the Kumasi metropolis, Ghana

Acute Oral Toxicological Profile of Croton membranaceus Mull. Arg. Aqueous Stem Extract, a Herbal Treatment for Benign Prostate Hyperplasia, in Male Sprague–Dawley Rats

Phytonutrients and technological development in formulations

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