Post‐Kala‐Azar Dermal Leishmaniasis in an HTV‐Patient

Unusual manifestations of tegumentary leishmaniasis in AIDS patients from the New World

“…16,17 Frequently, cutaneous lesions in HIV-infected patients are associated with visceral leishmaniasis resembling postkala-azar dermal leishmaniasis. 18,19 As the clinical manifestations of tegumentary leishmaniasis in HIV-infected patients are likely to be dependent on immunological status, and as the presence of severe immunosuppression may modify the clinical characteristics of the disease, hindering the diagnosis of tegumentary leishmaniasis by physicians, we investigated tegumentary leishmaniasis in HIV-infected patients, focusing on clinical manifestations, diagnosis, immunological status and outcome. These patients were from institutions that concentrate a considerable proportion of HIV patients from São Paulo city, São Paulo state, considered one of the most prevalent region for HIV in Brazil.…”

Parasite detection in patients with post kala-azar dermal leishmaniasis in India: a comparison between molecular and immunological methods

“…The incidence of leishmania/human immunodeficiency virus coinfection is increasing, and PKDL has been reported in patients infected with human immunodeficiency virus. [23][24][25] Although not standardised universally or used widely, PCR appears to be the most sensitive and specific assay for the diagnosis of PKDL, according to studies conducted in India and the Sudan. 14 15 Several DNA targets have been described for leishmania, such as ribosomal RNA genes, kinetoplast DNA, miniexon derived genes, and genomic repeats.…”

Nested PCR Assay for Detection of Leishmania donovani in Slit Aspirates from Post-Kala-Azar Dermal Leishmaniasis Lesions

“…The nested PCR assay used in the present study circumvented such limitations and showed a high degree of sensitivity even in macular cases. Cases of PKDL infection in patients with human immunodeficiency virus (HIV) have been reported (1,7). Since the incidence of HIV infection is on the increase in India, HIV patients coinfected with Leishmania are likely to present in the future.…”