Unusual manifestations of tegumentary leishmaniasis in AIDS patients from the New World

Abstract

Clinical manifestations of tegumentary leishmaniasis in HIV-infected patients are diverse. Our data emphasize possible unusual manifestations of this disease in HIV-infected patients, particularly in severely immunosuppressed cases (< 200 CD4+ cells mm(-3)).

Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV

“…Mucosal leishmaniasis (ML) is defined as an uncontrolled Th1-type inflammation of the oropharyngeal region, presenting a disfiguring facial lesion and can occur after unsuccessful healing of a previous LCL 3 . Recent data demonstrate that HIV coinfection is crucial to unbalancing the immune response and could favour the occurrence of reactivated leishmanial lesions 4,5 . The report discusses some data concerning the anti-Leishmania specific cellular immune response of an HIV + ML patient.…”

“…Apparently, this restoration was dependent on predominating CD8 + rather than CD4 + responding T cells 6 . Another HIV + /ML case series showed that circulating CD4 + T cell count was < 150 cells/mm 3 and that the leishmaniasis clinical outcome showed strong variability among the patients 5 . To our knowledge, no data is available regarding the effects of early HIV infection on the cytokine profile of ML patients.…”

Leishmaniasis mucocutánea en un paciente con infección por VIH: Case report

“…Una revisión retrospectiva de 15 pacientes con leishmaniasis tegumentaria y SIDA en Brasil, encontró signos atípicos como pápulas, placas, nódulos y úlceras, algunas ubicadas en genitales 26 . Nuestro caso presentó signos típicos precoces de leishmaniasis mucocutánea como congestión nasal y secreción acuosa 8,27 .…”

Coinfection of Leishmania guyanensis and Human Immunodeficiency Virus–Acquired Immune Deficiency Syndrome: Report of a Case of Disseminated Cutaneous Leishmaniasis in Ecuador

“…Several cases of Leishmania-HIV coinfection have been reported with atypical presentations including disseminated forms. 3,4,14 Most immunocompetent individuals in Ecuador with CL present with a single ulcerative lesion. 7,10 It is important to note that the patient described herein, had a single localized lesion on his left leg (LCL) for the first 2 years before the disease disseminated all over his body.…”