Post-irradiation hyperamylasemia as a biological dosimeter

Dubray, Bernard; Girinski, Théo; Thames, Howard D.; Becciolini, Aldo; Porciani, Sauro; Hennequin, Christophe; Socié, Gèrard; Bonnay, M; Cosset, Jean‐Marc

doi:10.1016/0167-8140(92)90349-y

Cited by 33 publications

(19 citation statements)

References 14 publications

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“…Similar changes were observed for salivary a-amylase, considered to be a valid marker for injury of the acinous cells in the salivary glands (14,15). Its use as a biochemical dosimeter has recently been proposed (16).…”

supporting

confidence: 55%

Prognostic Significance of Tissue Polypeptide Antigen (TPA) in Head and Neck Carcinomas

Becciolini¹,

Porciani²,

Lanini³

et al. 1993

Acta Oncologica

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supporting

confidence: 55%

Prognostic Significance of Tissue Polypeptide Antigen (TPA) in Head and Neck Carcinomas

Becciolini¹,

Porciani²,

Lanini³

et al. 1993

Acta Oncologica

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“…This radiation injury is also observed in patients with thyroid cancer treated with iodine 131 ( 131 I) 25) . One study has reported that increased levels of amylase in serum were observed for doses to the parotid glands over 0.5 Gy and irradiation over 2 Gy to these glands induced higher levels of amylase, more than 2.5-times the upper normal value 24 hrs after irradiation in 91% of patients 26) . Another study also demonstrated a close correlation between the peak rise in serum amylase and the amount of parotid tissue in the treatment volume 27) .…”

Section: Discussionmentioning

confidence: 99%

Initial Symptoms of Acute Radiation Syndrome in the JCO Criticality Accident in Tokai-mura

Akashi¹,

Hirama²,

Tanosaki³

et al. 2001

JRR

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Initial symptoms/Acute radiation syndrome/Dose assessment/Criticality accidentA criticality accident occurred on September 30, 1999, at the uranium conversion plant in Tokai-mura (Tokai-village), Ibaraki Prefecture, Japan. When the criticality occurred, three workers saw a "blue-white glow," and a radiation monitor alarm was sounded. They were severely exposed to neutron and γ -ray irradiation, and subsequently developed acute radiation syndrome (ARS). One worker reported vomiting within minutes and loss of consciousness for 10 -20 seconds. This worker also had diarrhea an hour after the exposure. The other worker started to vomit almost an hour after the exposure. The three workers, including their supervisor, who had no symptoms at the time, were brought to the National Mito Hospital by ambulance. Because of the detection of γ -rays from their body surface by preliminary surveys and decreased numbers of lymphocytes in peripheral blood, they were transferred to the National Institute of Radiological Sciences (NIRS), which has been designated as a hospital responsible for radiation emergencies. Dose estimations for the three workers were performed by prodromal symptoms, serial changes of lymphocyte numbers, chromosomal analysis, and 24 Na activity. The results obtained from these methods were fairly consistent. Most of the data, such as the dose rate of radiation, its distribution, and the quality needed to evaluate the average dose, were not available when the decision for hematopoitic stem cell transplantation had to be made. Therefore, prodromal symptoms may be important in making decisions for therapeutic strategies, such as stem-cell transplantation in heavily exposed victims. S158 M. AKASHI ET AL.

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“…Sa survenue après ICT théra-peutique a déjà été rapportée [3,22] et pourrait être en relation avec l'éléva-tion de l'amylasémie, véritable marqueur biologique de l'ICT [7]. Ces symptômes sont souvent accompagnés de douleurs parotidiennes post-ICT [2-3, 15] dont l'incidence semble dépendre de la dose d'irradiation : 23 % après 2 Gy dans notre série contre 64,5 % après 10 Gy [3], au cours des 10 premières heures post-ICT.…”

Section: Discussionunclassified

Etude prospective de la symptomatologie clinique précoce après irradiation corporelle totale thérapeutique de 2 Gy

et al. 1995

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Post-irradiation hyperamylasemia as a biological dosimeter

Cited by 33 publications

References 14 publications

Prognostic Significance of Tissue Polypeptide Antigen (TPA) in Head and Neck Carcinomas

Prognostic Significance of Tissue Polypeptide Antigen (TPA) in Head and Neck Carcinomas

Initial Symptoms of Acute Radiation Syndrome in the JCO Criticality Accident in Tokai-mura

Etude prospective de la symptomatologie clinique précoce après irradiation corporelle totale thérapeutique de 2 Gy

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