This report documents work performed under the Spent Fuel and Waste Disposition's Spent Fuel and Waste Science and Technology program for the US Department of Energy (DOE) Office of Nuclear Energy (NE). This work was performed to fulfill Level 2 Milestone M2SF-22OR010201042, "FY2021 ORNL Report on High Burnup Sibling Pin Testing Results," within work package SF-22OR01020104 and is an update to the work reported in M2SF-21OR010201032, M2SF-19ORO010201026 and M2SF-19OR010201028. Sister Rod Destructive Examinations March 31, 2022 v Planned DE Status / Applicable Appendix Comments Five more tests with unpressurized specimens are expected to be completed in FY22. Tests using pressurized segments are planned to follow the unpressurized tests. DE.01 Measure internal pressure of five baseline and three heattreated rods Complete / Appendix CThe rod internal pressure and the void volume available inside the rod were measured for eight sister rods at room temperature (RT), and all pressures are within the publicly available database envelope. There is a clear correlation between the post-irradiated rod internal pressure and the as-designed fill pressure. The fission gas partial pressure trends well with the rod average burnup. The pressure and void volumes measured are consistent for rods from the same fuel vendor. The product of the partial pressure of the fission gas and the void volume, P f V, is consistent from lab to lab for sister rods from the same assembly, except for the two rods from assembly F35. A comparison of P f V indicates that the ZIRLO-clad rods might have experienced some change in pressure, void volume, or both due to the heat treatment applied, but the M5-clad rods do not exhibit the same effects.Comparisons with predictions from fuel rod performance codes FAST and BISON indicate a tendency for FAST to underpredict pressure and BISON to overpredict pressure.