Post-irradiation carcinosarcoma of the parotid gland

Abstract

Carcinosarcoma of the salivary glands are rare tumours, often associated with a history of pleomorphic adenoma. A case of carcinosarcoma of the parotid arising following irradiation to the resection site of a pleomorphic adenoma is presented. The clinical and histological features are discussed and the literature reviewed.

Histologic Transformation of Polymorphous Low-Grade Adenocarcinoma of Salivary Gland

“…36 Radiation-induced transformation or progression of salivary gland tumors to a higher grade has been reported infrequently. [37][38][39] Non-radiation-related "dedifferentiation" of salivary gland tumors is also an uncommon phenomenon. 40,41 Whether histologic progression in the 2 cases we report was related to treatment with radiation is unclear.…”

Carcinosarcoma of submandibular salivary gland: our experience of a rare tumour with review of literature

“…14,15 A history of exposure to irradiation of pleomorphic adenoma has been reported as a cause. 16,17 The reported interval between the irradiation and the onset of carcinosarcoma varies from 1 to 36 years.…”

True malignant mixed tumour (carcinosarcoma) of submandibular gland— a rare neoplasm of monoclonal origin?

“…Thus, TMMT is not a collision of separate entities, but might be a tumour with various differentiated components of a pluripotent precursor lesion. A few authors have discussed other points of view 2,11 , 12 . They interpret the various immunohistochemical results in tumour subsets as evidence of their different origin 11,13 .…”

“…A few authors have discussed other points of view. 2,11,12 They interpret the various immunohistochemical results in tumour subsets as evidence of their different origin. 11,13 However, immunohistochemical analysis alone does not allow a b 15,16 losses of chromosome 18 as seen in our case have also been reported.…”