Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study

Abstract

Objective To delineate the risk factors, symptom patterns, and longitudinal course of prolonged illnesses after a variety of acute infections.

Chronic Lyme Disease: A Review

“…A recent study showed that post-infective fatigue syndrome could be predicted by the severity of the acute illness, and its incidence was similar after the different infections [43]. In this cohort, the case rate for provisional post-infective fatigue syndrome was 35% (87/250) at six weeks, 27% (67/250) at three months, and 9% (22/250) at 12 months [43]; rates similar to those reported in patients treated for erythema migrans (see above) [13]. The mechanisms that are triggered during the acute illness and that sustain the persistent symptoms in post-infective fatigue syndrome are currently unknown.…”

Polymorphisms in Toll-like receptors-2 and -4 are not associated with disease manifestations in acute Q fever

“…Self-report measures of symptom severity and functional impairment were recorded at regular intervals over 12 months as described. 2 A severity index of the acute illness was based on the score in the SOMA subscale of the SPHERE questionnaire, which has been shown to correlate with significant disability due to illness and the need for medical care in this cohort. The duration of illness was designated as the number of days from onset to resolution of significant illness on the SOMA subscale (reflected by a score of three or more out of the possible 12 on the scale).…”

“…A protracted clinical course marked by fatigue is common. 2 However, subclinical infections are at least four times more common than overt illness.…”

Caracterización del estado de salud de las personas en su periodo de convalecencia de un episodio de dengue

“…Los estados de fatiga prolongada después de las infecciones son comunes y pueden ser incapacitantes para las personas que los padecen. En cuanto a su duración, se ha reportado que pueden persistir durante 12 meses o más, y que pueden convertirse en estados de fatiga crónica (26,33). Aunque la fase aguda de las infecciones puede variar, la fatiga se presenta con características clínicas similares en estas enfermedades (33).…”

“…En cuanto a su duración, se ha reportado que pueden persistir durante 12 meses o más, y que pueden convertirse en estados de fatiga crónica (26,33). Aunque la fase aguda de las infecciones puede variar, la fatiga se presenta con características clínicas similares en estas enfermedades (33). Su etiología aún no se ha descrito con precisión, de la fase aguda, entre los cuales predominó el cansancio físico (65,6 %), la cefalea (37,5 %), el insomnio (31,3 %), el mareo, el cansancio mental (25 %) y el dolor muscular (18,8 %).…”