Post-Infectious Functional Gastrointestinal Disorders in Children

Henoch–Schonlein Purpura Leads to Functional Gastrointestinal Disorders

“…The role of inflammation and its interaction with the enteric neuro-immune system constitutes an area of increasing interest. Studies have demonstrated that post-infectious-IBS (PI-IBS) may develop as sequelae of acute infectious gastroenteritis in adults and children [6][7][8][9][10][11][12][13].…”

“…This model proposes that there is no single etiology for these conditions. Recent studies have demonstrated that pain predominant FGIDs such as irritable bowel syndrome (IBS) may develop as sequelae to acute infectious gastroenteritis [6][7][8][9][10][11][12][13]. Evidence in support of this post-infectious etiology is compelling with persistent low-grade inflammation, immune activation, and nerve sensitization present long after the acute infection has resolved [7,[14][15][16].…”

Global Epidemiology of Campylobacter Infection

“…jejuni and other Campylobacter species are associated with the development of foodborne gastroenteritis-associated sequelae, including postinfectious functional gastrointestinal disorders (PFGD). Two PFGD have received the most attention: irritable bowel syndrome (IBS) (150)(151)(152)(153)(154)(155)(156) and functional dyspepsia (FD) (156)(157)(158)(159)(160)(161). IBS is defined by recurrent abdominal pain or discomfort during at least 3 days/month in the last 3 months, associated with an alteration of bowel habits (diarrhea, constipation, or both), in accordance with the Rome III classification system (162).…”

Rezidivierende Bauchschmerzen durch Dünndarminvaginationen

“…Ursache war eine Campylobacter-jejuni-Infektion, die antibiotisch behandelt wurde. Danach entwickelte der Junge wieder intermittierende leichtere Bauchschmerzen anderer Qualität im Sinne eines postinfektiösen Reizdarms nach bakterieller Gastroenteritis [12,14]. Seither ist der Patient über 18 Monate völlig beschwerdefrei.…”