Post herpes zoster infection neuromyelitis optica spectrum disorder

Mathew, Thomas; Thomas, Kurian; Shivde, Sonia; Venkatesh, Shruthi; Rockey, Smitha Mary

doi:10.1016/j.msard.2017.09.022

Cited by 16 publications

(5 citation statements)

References 5 publications

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“…Viral infections precede NMOSD in 15-35% of the cases, but their linkage with anti-AP4 antibodies is as yet unknown [2]. Among viral infections preceding NMOSD, the most common are VZV [6][7][8], mumps [9], HIV [10], and Epstein-Barr virus [11]. Possible mechanisms to explain the association of autoimmunity with virus infection are bystander activation, in which microbes damage AP4-rich tissue provoking the activation of AP4-specific T-and B-cells against the CNS or molecular mimicry, in which the activation of B-cells produces antibodies that recognize both microbial epitopes and self-epitopes [2].…”

Section: Discussionmentioning

confidence: 99%

Neuromyelitis Optica Spectrum Disorder Attack Triggered by Herpes Zoster Infection

Turco

Curti

Maffini

et al. 2020

Multiple Sclerosis International

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Neuromyelitis optica spectrum disorder is a severe autoimmune disease of the central nervous system characterized by recurrent inflammatory events primarily involving the optic nerves and spinal cord. Recently, a triggering role of infectious events in the development of NMOSD has been suggested. Varicella zoster virus is the most common viral infection involved, though the linkage with anti-aquaporin-4 antibodies is so far unknown. We report, to the best of our knowledge, the first pediatric case report about NMOSD relapse triggered by herpes zoster infection. The strict temporal relationship between VZV infection and NMO attacks seems to be more than simply due to chance; however, further reports are needed to be confirmed.

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Section: Discussionmentioning

confidence: 99%

Neuromyelitis Optica Spectrum Disorder Attack Triggered by Herpes Zoster Infection

Turco

Curti

Maffini

et al. 2020

Multiple Sclerosis International

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“…Primary EBV infection in children is usually asymptomatic, and usually leads to mononucleosis when it occurs in adulthood [44]. The above herpesvirus infections have all been reported in the previous NMOSD cases, with VZV being the most common pathogen [45][46][47][48][49]. A systematic review reported that 14 NMOSD patients (eight with AQP4-ab) had prodromal VZV infection, four presenting with chickenpox and the rest with shingles [50].…”

Section: Discussionmentioning

confidence: 99%

Causal associations between prodromal infection and neuromyelitis optica spectrum disorder: A Mendelian randomization study

Wang

Zhou

ZhangBao

et al. 2023

Euro J of Neurology

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Background and purposeProdromal infection is associated with neuromyelitis optica spectrum disorder (NMOSD), but which type of infection had causal relations with NMOSD remains unclear. We aimed to explore the causal relations between four herpesvirus infections (chickenpox, cold sores, mononucleosis and shingles) and NMOSD, as well as other types of infections and NMOSD.MethodsFor infections, the genome‐wide association study (GWAS) summary statistics from the 23andMe cohort were used. For outcomes, the GWAS of participants from European ancestry was used, including 215 NMOSD patients (132 anti‐aquaporin‐4 antibody [AQP4‐ab]‐positive patients and 83 AQP4‐ab‐negative patients) and 1244 normal controls. Single nucleotide polymorphism (SNP) identification and two‐sample mendelian randomization (MR) analyses were then performed.ResultsIn 23andMe cohort, we identified one SNP (rs9266089 in HLA‐B gene) for chickenpox, one SNP (rs885950 in POU5F1 gene) for cold scores, one SNP (rs2596465 in HCP5 gene) for mononucleosis, three SNPs (rs2523591 in HLA‐B gene; rs7047299 in IFNA21 gene; rs9260809 in MICD gene) for shingles. The relation of cold sores and AQP4‐ab‐positive NMOSD reached statistical significance (OR [95%CI] = 745.318 [22.176, 25049.53], P < 0.001, Q < 0.001). The association of shingles and AQP4‐ab‐positive NMOSD was statistically significant (OR [95%CI] = 21.073 [4.271, 103.974], P < 0.001, Q < 0.001). No significant association was observed between other infections and AQP4‐ab‐positive or AQP4‐ab‐negative NMOSD.ConclusionThese findings suggested the positive associations between cold sores, shingles and AQP4‐ab‐positive NMOSD, indicating there may be causal relations between herpes simplex virus, varicella‐zoster virus infection and AQP4‐ab‐positive NMOSD.

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“…[2][3][4] In some patients, Varicella Zoster induced LETM has been associated with anti-aquaporin-4 antibody serology indicating association to neuromyelitis optica spectrum disorder. [5][6][7][8]…”

Section: Introductionmentioning

confidence: 99%

Longitudinally extensive transverse myelitis with aquaporin-4 antibody after herpes zoster: A case report

Dubey

Rohatgi

Khan

et al. 2022

ijhs

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Varicella zoster virus (VZV) is human neurotropic virus. It becomes latent in dorsal root ganglia; it may reactivate and can cause dermatological manifestations; most common is herpes zoster. Several neurological disorders can occur such as encephalitis, meningitis, myelitis and neuropathy. Longitudinally extensive transverse myelitis is infrequent.The association of AQP4 antibody with Varicella zoster has been documented in few case reports. Here we report a case of young woman who developed longitudinally extensive transverse myelitis with positive AQP4 antibody titers following varicella zoster infection.

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Post herpes zoster infection neuromyelitis optica spectrum disorder

Cited by 16 publications

References 5 publications

Neuromyelitis Optica Spectrum Disorder Attack Triggered by Herpes Zoster Infection

Neuromyelitis Optica Spectrum Disorder Attack Triggered by Herpes Zoster Infection

Causal associations between prodromal infection and neuromyelitis optica spectrum disorder: A Mendelian randomization study

Longitudinally extensive transverse myelitis with aquaporin-4 antibody after herpes zoster: A case report

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