Post COVID-19 large pneumatocele: clinical and pathological perspectives

Hamad, Abdel-Mohsen; El-Saka, Hala Ahmed

doi:10.1093/icvts/ivab072

Cited by 19 publications

(26 citation statements)

References 5 publications

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“…Regarding histological evaluation, Hamad et al reported a thin tissue wall demarcating lesions similar to PHC, with marked fibroblast proliferation, lymphocyte infiltration, intra-alveolar hemorrhage, and pneumocyte proliferation [ 11 ]. According to our findings, the histological changes were similar when the lesion was close to the pleura, but in intrapulmonary cases, the connective tissue surrounding the hematic material showed a reactive inflammatory process secondary to a foreign body, very different from the previous descriptions of COVID-19 lung affection as diffuse alveolar damage, organizing pneumonia, reactive type II pneumocytes, and chronic interstitial pneumonia [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…As the COVID-19 pandemic has continued worldwide during 2020 and 2021, an increasing number of long-term complications are emerging, such as cardiac affection [1,2], neurologic disorders [3,4], and pulmonary fibrosis [5,6]. Recently, the appearance of characteristic pulmonary lesions has been noted, being described as "giant bulla" [7][8][9] or post-COVID-19 pneumatocele [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Post COVID-19 pneumo-hematocele: clinical presentation and treatment pathway

Chávez¹,

Pimienta-Ibarra

Máruquez-González

et al. 2022

Gen Thorac Cardiovasc Surg

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Objectives The appearance of characteristic pulmonary lesions has been noted after COVID-19, being described as post-COVID-19 pneumo-hematocele. The aim of this study is to describe the clinical, histopathologic, and imaging features of pneumo-hematocele and to suggest a treatment algorithm for these patients. Methods A retrospective study was performed in patients admitted with a diagnosis of SARS-CoV2 infection from March 2020 to September 2021 who presented a pneumo-hematocele on imaging studies. Clinical and demographic variables were recorded, and CT scans were analyzed. A secondary analysis was performed to estimate the risk provided by the pneumo-hematocele diameter of developing pneumothorax. Results 37 patients were diagnosed with pneumo-hematoceles, 97.3% were males with a median age of 41 ± 13 years and 51% were smokers. The mean diameter of the pneumatocele was 6.3 ± 2.8 cm; they were more common on the subpleural surface and in the inferior lobe. Thirty patients had ruptured pneumo-hematoceles and developed pneumothorax (81.1%); a total of 26 patients required surgery (70.3%). Lesions measuring 5 cm had a high risk of rupture (OR 6.8, CI 95% 1.1–42); those measuring 3 cm were prone to this complication. For each centimeter that the pneumo-hematocele diameter increases, the OR for rupture increases 1.5. Conclusions It appears that post-COVID-19 pneumo-hematocele occurs secondary to encapsulation of blood accumulation inside the lung, as a result of micro-capillary bleeding, with partial reabsorption of blood and subsequent air filling. We recommend surgery for patients with pneumo-hematoceles of 5 cm and those with persistent lesions of 3 cm. Trial registration Clinical Trial Registration: NCT05067881.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Post COVID-19 pneumo-hematocele: clinical presentation and treatment pathway

Chávez¹,

Pimienta-Ibarra

Máruquez-González

et al. 2022

Gen Thorac Cardiovasc Surg

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“… 15 , 16 Failure of this technique should lead to surgical pneumonostomy 17 or resection. 18 , 19 On the contrary, in critically ill patients, surgical approach seems more reasonable as the first choice of intervention, since it may be life‐saving. In this case, the patient substantively recovered on conservative management without any need for surgical intervention.…”

Section: Discussionmentioning

confidence: 99%

Pneumatocele in a Ugandan female with SARS‐CoV2 infection: A case report

Srikant

Darshit

Dave

2022

Clinical Case Reports

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“…To this day, we know only the short-and medium-term results of COVID-19 involvement. It has been reported that the disease causes cystic changes like pneumatocele [11]. Apart from this, when infection occurs in small calibre (<5mm) cystic lesions within GGO areas, it is known as the vacuolar sign [12].…”

Section: Discussionmentioning

confidence: 99%

A case of B.1.1.7 SARS-CoV-2 UK strain with an atypical radiological presentation

Doğan

Tapan

et al. 2021

Monaldi Arch Chest Dis

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The new UK strain was first described in December 2020. It was seen for the first time in Turkey in February 2021. It is not yet known whether the new strain has different CT patterns compared to the classical type. We present a 68-years-old male patient with an atypical CT presentation in which GGOs are gathered around the areas of paraseptal emphysema accompanied by CT and clinical findings. This involvement is an unexpected pattern because of the atypical distribution of the GGO.

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Post COVID-19 large pneumatocele: clinical and pathological perspectives

Cited by 19 publications

References 5 publications

Post COVID-19 pneumo-hematocele: clinical presentation and treatment pathway

Post COVID-19 pneumo-hematocele: clinical presentation and treatment pathway

Pneumatocele in a Ugandan female with SARS‐CoV2 infection: A case report

A case of B.1.1.7 SARS-CoV-2 UK strain with an atypical radiological presentation

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