Post‐COVID‐19 complications: Multisystemic approach

Suvvari, Tarun Kumar; Kutikuppala, LV Simhachalam; Tsagkaris, Christos; Corriero, Anna Chiara; Kandi, Venkataramana

doi:10.1002/jmv.27222

Cited by 29 publications

(22 citation statements)

References 24 publications

(34 reference statements)

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“…[ 39 ] The COVID-19 pandemic is an ongoing global health crisis, causing progressive pneumonia and may be complicated by and multi-organ failure. [ 40 , 41 ] There are conflicting views on the role of immunosuppressants in COVID-19. Some argue that immunosuppressive drugs have a negative effect on the disease's progression.…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 (COVID-19) pneumonia patient treated with two doses of infliximab within 2 weeks for acute severe ulcerative colitis

Alhalabi¹,

Eddin²,

Ali³

et al. 2022

Medicine

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Rationale: The ongoing coronavirus pandemic has caused severe acute respiratory syndrome, posing a significant challenge for patients receiving immunotherapy for immune-mediated inflammatory diseases. As of January 2022, immunosuppressants such as tumor necrosis factor inhibitors (anti-TNFα) and azathioprine are inadvisable for an infectious disease caused by the SARS-CoV-2 virus (COVID-19). We continued infliximab as a second induction dose nine days after the onset of COVID-19 symptoms in a patient with acute severe ulcerative colitis. Patient concerns: We report the case of a 34-year-old male with 6 to 8 times bloody diarrhea, fever, and cramping abdominal pain. Ulcerative colitis was diagnosed 6 months earlier and treated with mesalamine 80 mg/kg/day and azathioprine 2.5 mg/kg/day. The patient had never undergone surgery before. Sigmoidoscopy revealed multiple ulcerations and spontaneous bleeding, and the colon samples tested negative for cytomegalovirus and Clostridium difficile. However, intravenous corticosteroids did not induce remission. A nasopharyngeal swab tested positive for SARS-CoV-2. Diagnosis: Acute severe ulcerative colitis and SARS-CoV-2 (COVID-19) pneumonia. Interventions: The second loading dose of infliximab was administered nine days after the diagnosis of COVID-19. Outcome: The patient completed infliximab induction at a dose of 5 mg/kg at weeks 0, 2, and 6, with no complications. Lessons: It is unclear whether anti-TNF-α treatment improves or deteriorates COVID-19 patient outcomes, and this case demonstrates that infliximab can be used safely. Current guidelines make a weak recommendation to avoid using anti-TNFα agents in the presence of acute COVID-19 infection. There is an urgent need for research on biologics therapy.

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Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 (COVID-19) pneumonia patient treated with two doses of infliximab within 2 weeks for acute severe ulcerative colitis

Alhalabi¹,

Eddin²,

Ali³

et al. 2022

Medicine

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“…Presently, most of the people who had infected with COVID-19 are showing complications related to pulmonary systems [ 42 ]. Since, the present formulations have shown significant role in improvement in lung pathology, therefore, the FEO's could also be used to treat COVID-19 and post-COVID-19 lung complications.…”

Section: Discussionmentioning

confidence: 99%

Integrating in silico and in vivo approach for investigating the role of polyherbal oil in prevention and treatment of COVID-19 infection

Bahl¹,

Verma

Bhatia

et al. 2022

Chemico-Biological Interactions

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“…To avoid being stigmatized, they might have avoided respectful maternity care practices such as client interaction and communication (39,40). Also, other possible reasons could be decreased mental and physical performance due to stigma, psychological distress, and diseases (41,42). Therefore, more physical and mental health support to the healthcare providers should be provided to improve their performance (43).…”

Section: Discussionmentioning

confidence: 99%

Association of Workload and Practice of Respectful Maternity Care Among the Healthcare Providers, Before and During the COVID-19 Pandemic in South Western Nepal: A Cross-Sectional Study

Pokharel¹,

Kiriya

Shibanuma

et al. 2022

Preprint

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Introduction: Respectful maternity care is a crucial component of intrapartum quality care. As the imbalance in demand and supply of the maternity care workforce affects intrapartum quality care, respectful maternity care might be affected by increased workload among the healthcare providers. Thus, this study was conducted to examine the association between workload among healthcare providers and their practice of respectful maternity care, both before and during the COVID-19 pandemic. Methods: A cross-sectional study was conducted in South Western Nepal. A total of 78 birthing centers and 267 healthcare providers were included. Data collection was done through telephone interviews. The exposure variable was workload among the healthcare providers, and the outcome variable was respectful maternity care practice before and during the COVID-19 pandemic. Multilevel mixed-effect linear regression was used to examine the association. Results: The median client-provider ratio before and during the pandemic was 21.7 and 13.0, respectively. The mean score of respectful maternity care practice was 44.5 (SD 3.8) before the pandemic, which was decreased to 43.6 (SD 4.5) during the pandemic. Client-provider ratio was negatively associated with respectful maternity care practice for both times; before (Coef. -5.16; 95% CI -8.41 to -1.91) and during (Coef. -7.47; 95% CI -12.72 to -2.23) the pandemic. The variance of respectful maternity care practice among the health facilities was 26% before the pandemic, and was increased to 33% during the pandemic. Being tested positive for COVID-19 in the past was negatively associated with respectful maternity care practice during the COVID-19 pandemic (Coef. -3.18; 95% CI -5.06 to -1.30). Conclusions: While a higher client-provider ratio was associated with a lower respectful maternity care practice score both before and during the COVID-19 pandemic, the coefficient was larger during the pandemic. Also, the variance among the health facilities for respectful maternity care was increased more during the COVID-19 pandemic. The findings of this study call for the decrement in the client-provider ratio for better respectful maternity care practice, especially during the pandemic. However, supplying health human resources per the population demand, especially during the pandemic, may be difficult in a resource-limited setting. The number of delivery cases at local health facilities should be increased by improving the quality of care, particularly during the pandemic. This could help equal distribution of client-provider and practice respectful maternity care, even during the pandemic. Further, healthcare providers who tested positive for COVID-19 had lower respectful maternity care practice scores. Therefore, additional physical and mental health support to healthcare providers should be considered to improve their respectful maternity care practice, particularly during the pandemic.

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Post‐COVID‐19 complications: Multisystemic approach

Cited by 29 publications

References 24 publications

SARS-CoV-2 (COVID-19) pneumonia patient treated with two doses of infliximab within 2 weeks for acute severe ulcerative colitis

SARS-CoV-2 (COVID-19) pneumonia patient treated with two doses of infliximab within 2 weeks for acute severe ulcerative colitis

Integrating in silico and in vivo approach for investigating the role of polyherbal oil in prevention and treatment of COVID-19 infection

Association of Workload and Practice of Respectful Maternity Care Among the Healthcare Providers, Before and During the COVID-19 Pandemic in South Western Nepal: A Cross-Sectional Study

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