Post-coital antifertility activity of Ruta graveolens in female rats and hamsters

Gandhi, Manoj; Lal, Roshan; Sankaranarayanan, A; Sharma, Pankaj

doi:10.1016/0378-8741(91)90188-j

Cited by 39 publications

(14 citation statements)

References 33 publications

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“…If this plant is used in vaginal contraception, it also may prevent some sexually transmitted disease. Considering RGL as a potent abortive agent (Conway and Slocumb, 1979;Gandhi et al, 1991;Gutierrez-Pajares et al, 2003;Unny et al, 2003;Maurya et al, 2004;de Freitas et al, 2005) and our preliminary data, it seems that Ruta graveolens L. can act as a novel contraception both in men and women. Its exact mechanism of action is not understood yet and more experiment shall be done to reveal its real effect as a contraceptive plant.…”

Section: Discussionmentioning

confidence: 93%

“…It is one of the most ancient and effective contraceptive plants (Maurya et al, 2004). Its potent female antifertility and abortive effects have been reported from countries like Brazil (de Freitas et al, 2005), India (Gandhi et al, 1991), Peru (Gutierrez-Pajares et al, 2003) and Mexico (Conway and Slocumb, 1979), both according to their traditional usage and in animal studies.…”

Section: Introductionmentioning

confidence: 94%

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Immobilization effect of Ruta graveolens L. on human sperm: A new hope for male contraception

Harat

Sadeghi

Sadeghipour

et al. 2008

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 94%

Immobilization effect of Ruta graveolens L. on human sperm: A new hope for male contraception

Harat

Sadeghi

Sadeghipour

et al. 2008

Journal of Ethnopharmacology

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“…This indicates the lack of antiestrogenic activity in this plant, and this goes to show that it is safe for therapeutic use in women of reproductive age. Plants that exhibit antiestrogenic activity have the capacity of interrupting the gestation of rats and mice, by the inhibition of the estrogen necessary for implantation (Ghandi et al, 1991). In mice and humans, estrogen has an important role in implantation, as it participates in the estrogen/progesterone balance and in the receptivity of the uterus to the embryo (Ements, 1970).…”

Section: Resultsmentioning

confidence: 99%

Study of reproductive toxicity of Combretum leprosum Mart and Eicher in female Wistar rats

Oliveira¹,

Santos²,

Cardoso³

et al. 2013

Afr. J. Biotechnol.

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Most plants culturally used in Brazil for medicine do not have pre-clinical studies of reproductive toxicity, therefore risks of using such products on the reproductive system are unknown. The aim of the study was to evaluate possible reproductive toxicity of ethanolic extract of Combretum leprosum Mart and Eicher (EECL) in female Wistar rats. The animals, weighing between 180 to 250 g, were maintained in controlled environmental conditions of temperature, humidity, light/dark cycle of 12/12 h, water ad libitum and fed with commercial diet for rats. To verify the estrogenic activity of EECL, four groups of ovariectomized rats were used: saline + corn oil; saline + estradiol; EECL (500 mg/kg) + corn oil; EECL (500 mg/kg) + estradiol. To study the reproductive toxicity during the fecundation and implantation phases of the embryos and also during the organogenesis phase, two groups were used for each experiment, saline and EECL (500 mg/Kg). No estrogenic or anti-estrogenic activities were observed in the EECL. The ingestion of EECL did not cause modification in the number of implantation sites, which indicates a lack of toxicity during this phase. The EECL administered orally in the dose of 500 mg/kg did not produce adverse effects on the reproductive system of the female rats.

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“…1) Ruta graveolens L. (Family: Rutaceae) is a medicinal plant which has been traditionally used as a sedative and antihelmintic to relieve menstrual and gastrointestinal disorders. 2,3) Also hypotensive, 4,5) antifertility, [6][7][8] anti-inflammatory effects have also been claimed as further analgesic actions of this plant. 9,10) Most of these biological properties that have been denoted by preceding studies are likely related to some chemical constituents including flavonoids.…”

mentioning

confidence: 99%

“…9,10) Most of these biological properties that have been denoted by preceding studies are likely related to some chemical constituents including flavonoids. 4,11) Flavonoids are a group of naturally occurring phenolic compounds that are a part of primary chemical components of R. graveolens L. 4,6,11) The most important analyzed flavonoid in R. graveolens L. is rutin (quercetin-3-O-b-rutinoside) that belongs to flavonol glycoside. Quercetin is another major flavonoid found in R. graveolens L. and can also be obtained by rutin hydrolysis (Fig.…”

mentioning

confidence: 99%

Inhibitory Effects of Ruta graveolens L. Extract on Guinea Pig Liver Aldehyde Oxidase

Pirouzpanah

Reza

Delazar

et al. 2006

CHEMICAL & PHARMACEUTICAL BULLETIN

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Ruta graveolens L. is a flavonoid-containing medicinal plant with various biological properties. In the present study, the effects of R. graveolens extract on aldehyde oxidase, a molybdenum hydroxylase, are investigated. Aldehyde oxidase was partially purified from liver homogenates of mature male guinea pigs by heat treatment and ammonium sulphate precipitation. The total extract was obtained by macerating the aerial parts of R. graveolens in MeOH 70% and the effect of this extract on the enzyme activity was assayed using phenanthridine, vanillin and benzaldehyde as substrates. Quercetin and its glycoside form, rutin were isolated, purified and identified from the extract and their inhibitory effects on the enzyme were investigated. R. graveolens extract exhibited a high inhibition on aldehyde oxidase activity (89-96%) at 100 m mg/ml which was comparable with 10 m mM of menadione, a specific potent inhibitor of aldehyde oxidase. The IC 50 values for the inhibitory effect of extract against the oxidation of benzaldehyde, vanillin and phenanthridine were 10.4, 10.1, 43.2 m mg/ml, respectively. Both quercetin and rutin at 10 m mM caused 70-96% and 27-52% inhibition on the enzyme activity, respectively. Quercetin was more potent inhibitor than rutin, but both flavonols exerted their inhibitory effects mostly in a linear mixed-type.

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Post-coital antifertility activity of Ruta graveolens in female rats and hamsters

Cited by 39 publications

References 33 publications

Immobilization effect of Ruta graveolens L. on human sperm: A new hope for male contraception

Immobilization effect of Ruta graveolens L. on human sperm: A new hope for male contraception

Study of reproductive toxicity of Combretum leprosum Mart and Eicher in female Wistar rats

Inhibitory Effects of Ruta graveolens L. Extract on Guinea Pig Liver Aldehyde Oxidase

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