Possible use of quercetin, an antioxidant, for protection of cells suffering from overload of intracellular Ca2+: A model experiment

Changes of intracellular Ca<sup>2+</sup> in quercetin-induced autophagy progression

“…Cadmium-induced autophagy and apoptosis were also mediated by a calcium-signaling pathway, but quercetin manifested a protective effect against cadmium-induced cytotoxicity in rPT cells through inhibiting apoptosis, attenuating lipid peroxidation, and renewing mitochondrial function, followed by elevation of the non-enzymatic and enzymic antioxidants levels [28,29]. However, published results about the function of intracellular Ca 2+ in autophagy induced by quercetin are still controversial [30]. In the present study, quercetin was found to induce autophagy and the elevation of [Ca 2+ ] i .…”

Hydrogen Peroxide Induces Cell Cycle Arrest in Cardiomyoblast H9c2 Cells, Which Is Related to Hypertrophy

“…of three independent experiments. 15,24,25) and Ca 2ϩ participates in several pathways that induce cell cycle arrest. 15,24) Santini et al found that the calcineurin/nuclear factor of activated T-cell (NFAT) pathway, which is activated by intracellular Ca 2ϩ and induces p21 expression, is involved in cell cycle arrest during keratinocyte differentiation induced by the addition of Ca 2ϩ .…”

Pathological and Ultra-structural Changes in Testis of Rats due to Doxorubicin Toxicity and its Amelioration with Quercetin

“…It is considered to be a strong antioxidant due to its ability to scavenge free radicals and bind transition metal ions (Hollman and Katan 1997; Sakanashi et al, 2008).…”