Possible ultraviolet A—induced lentigines: A side effect of chronic tanning salon usage

Roth, Donna E.; Hodge, Steven J.; Callen, Jeffrey P.

doi:10.1016/s0190-9622(89)70117-1

Cited by 14 publications

(7 citation statements)

References 19 publications

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“…We found a significant association between ever sunbed use and lentigines after adjustment for potential confounders, including sun exposure and sunscreen use. This confirms previous case reports of lentigines occurring after sunbed exposure . Interestingly, these observations reported that the lentigines induced by artificial tanning (so‐called ‘sunbed lentigines’) have more worrisome pathologic and ultra‐structural features than common solar lentigines, such as the presence of melanocytic nuclear atypia and abnormally clumped, pleomorphic melanosomes.…”

Section: Discussionsupporting

confidence: 90%

“…This confirms previous case reports of lentigines occurring after sunbed exposure. [14][15][16][17][18][19] Interestingly, these observations reported that the lentigines induced by artificial tanning (so-called 'sunbed lentigines') have more worrisome pathologic and ultra-structural features than common solar lentigines, such as the presence of melanocytic nuclear atypia and abnormally clumped, pleomorphic melanosomes. Moreover, excised 'sunbed lentigines' lacked solar elastosis, which is instead typical of common solar 1 In order to calculate the odds ratio for Georgia, the model for this country was not adjusted for age, skin type and personal history of skin cancer, due to frequency of suspected melanoma being too low in exposed individuals.…”

Section: Discussionmentioning

confidence: 99%

“…The potential of sunbed exposure to cause melanocytic atypia might explain the significant, though small association of ever sunbed use with atypical nevi in our multivariate analysis. In 1989, Roth et al 16 described the case of a woman developing several dysplastic junctional nevi after an extended period of UVA tanning booth use. To our knowledge, the present study provides the first significant association between ever use of sunbeds and presence of atypical nevi in a large multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, the International Agency for Research on Cancer (IARC) currently regards the whole spectrum of ultraviolet (UV) radiation as well as UV‐emitting tanning devices as first‐group carcinogens alongside tobacco smoking and asbestos . Associations between indoor tanning exposure and melanoma's risk factors such as high nevus count, atypical nevi and lentigines have also been suggested, though not extensively studied up to date …”

Section: Introductionmentioning

confidence: 99%

“…9,10 Associations between indoor tanning exposure and melanoma's risk factors such as high nevus count, atypical nevi and lentigines have also been suggested, though not extensively studied up to date. [11][12][13][14][15][16][17][18][19] Euromelanoma is a skin cancer prevention campaign that is conducted all over Europe since almost two decades. [20][21][22] Its main goal is to promote awareness of skin cancer among the general public.…”

Section: Introductionmentioning

confidence: 99%

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Association of sunbed use with skin cancer risk factors in Europe: an investigation within the Euromelanoma skin cancer prevention campaign

Suppa

Gandini

Njimi

et al. 2019

Acad Dermatol Venereol

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Introduction Sunbed use has been significantly associated with increased risk of melanoma and non‐melanoma skin cancer (NMSC), but its relationship with melanoma's risk factors such as high nevus count, atypical nevi and lentigines is poorly studied. Euromelanoma is a skin cancer prevention campaign conducted all over Europe. It offers a once‐a‐year screening during which participants’ data, including sunbed use and phenotype, are collected via questionnaires. Objectives To investigate the association of sunbed use with nevus count, atypical nevi, lentigines and suspicion of skin cancer. Methods To ensure reliability of the data, we defined inclusion and exclusion criteria for countries’ eligibility for the risk analysis. Multivariate logistic regression models (including age, gender, education, skin type, family history of melanoma, personal history of skin cancer, any sun exposure and any sunscreen use) were used to calculate summary odds ratios (SORs) of each clinical endpoint for ever sunbed use. Results Overall, 227 888 individuals from 30 countries completed the Euromelanoma questionnaire. After the data quality check, 16 countries were eligible for the multivariate analysis, for a total of 145 980 participants (64.8% females; median age 43 years; 62.3% highly educated; 28.5% skin type I–II; 11.0% ever sunbed use). Ever sunbed use was independently associated with nevus count >50 [SOR = 1.05 (1.01–1.10)], atypical nevi [SOR = 1.04 (1.00–1.09)], lentigines [SOR = 1.16 (1.04–1.29)] and suspicion of melanoma [SOR = 1.13 (1.00–1.27)]. Conversely, no significant association was found between ever sunbed use and suspicion of NMSC [SOR = 1.00 (0.91–1.10)]. Conclusions Indoor tanning is significantly associated with well‐recognized risk factors for melanoma (including high nevus count, presence of atypical nevi and lentigines) as well as suspicion of melanoma within the Euromelanoma screenees. In order to reduce the prevalence of melanoma risk factors, avoidance/discontinuation of sunbed use should always be encouraged, especially but not exclusively for individuals with high‐risk phenotypes.

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Section: Discussionsupporting

confidence: 90%