Possible treatment options for Parkinson’s disease

Baat, C. de; Stiphout, M.A.E. van; Dijk, Karin D. van; Berendse, H.W.; Verhoeff, Merel C.; Lobbezoo, Frank

doi:10.5177/ntvt.2019.03.18245

Cited by 1 publication

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“…Modern therapies for management of Parkinson’s disease have aimed to control symptoms, reduce disability, and improve quality of life [ 8 ]. To date, the mechanism of FOG is not clear enough, and this has limited direct and effective treatment the associated symptoms, as well as development of ideal drugs and surgical treatment [ 9 ]. In fact, drug therapy has generated little effect on improvement of FOG, while advanced cases have shown very poor response to available drugs [ 10 ].…”

Section: Background and Rationalementioning

confidence: 99%

Improvement of freezing of gait in patients with Parkinson’s disease by music exercise therapy: a study protocol for a randomized controlled trial

Zhou

et al. 2021

Trials

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Background Progression of freezing of gait, a common pathological gait in Parkinson’s disease, is an important risk factor for diagnosing the disease and has been shown to predispose patients to easy falls, loss of independent living ability, and reduced quality of life. Treating Parkinson’s disease with freezing of gait is very difficult, while the use of medicine and operation has been ineffective. Music exercise therapy, which entails listening to music as you exercise, has been proposed as a treatment technology that can change patients’ behavior, emotions, and physiological activity. In recent years, music exercise therapy has been widely used in treatment of motor disorders and neurological diseases and achieved remarkable results. Results from our earlier pilot study revealed that music exercise therapy can improve the freezing of gait of Parkinson’s patients and improve their quality of life. Therefore, we aim to validate clinical efficacy of this therapy on freezing of gait of Parkinson’s patients using a larger sample size. Methods/design This three-arm randomized controlled trial will evaluate clinical efficacy of music exercise therapy in improving the freezing of gait in Parkinson’s patients. We will recruit a total of 81 inpatients with Parkinson’s disease, who meet the trial criteria. The patients will randomly receive music exercise with and without music as well as routine rehabilitation therapies, followed by analysis of changes in their gait and limb motor function after 4 weeks of intervention. We will first use a three-dimensional gait analysis system to evaluate changes in patients’ gait, followed by assessment of their limb function, activity of daily living and fall risk. Discussion The findings of this trial are expected to affirm the clinical application of this therapy for future management of the disease. Trial registration Chinese Clinical Trial Registry ChiCTR1900026063. Registered on September 20, 2019

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Section: Background and Rationalementioning

confidence: 99%

Improvement of freezing of gait in patients with Parkinson’s disease by music exercise therapy: a study protocol for a randomized controlled trial

Zhou

et al. 2021

Trials

View full text Add to dashboard Cite

show abstract

Possible treatment options for Parkinson’s disease

Cited by 1 publication

References 0 publications

Improvement of freezing of gait in patients with Parkinson’s disease by music exercise therapy: a study protocol for a randomized controlled trial

Improvement of freezing of gait in patients with Parkinson’s disease by music exercise therapy: a study protocol for a randomized controlled trial

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