Improvement of freezing of gait in patients with Parkinson’s disease by music exercise therapy: a study protocol for a randomized controlled trial

Abstract

Background Progression of freezing of gait, a common pathological gait in Parkinson’s disease, is an important risk factor for diagnosing the disease and has been shown to predispose patients to easy falls, loss of independent living ability, and reduced quality of life. Treating Parkinson’s disease with freezing of gait is very difficult, while the use of medicine and operation has been ineffective. Music exercise therapy, which entails listening to music as you exercise, has been proposed as a treatment technology that can change patients’ behavior, emotions, and physiological activity. In recent years, music exercise therapy has been widely used in treatment of motor disorders and neurological diseases and achieved remarkable results. Results from our earlier pilot study revealed that music exercise therapy can improve the freezing of gait of Parkinson’s patients and improve their quality of life. Therefore, we aim to validate clinical efficacy of this therapy on freezing of gait of Parkinson’s patients using a larger sample size. Methods/design This three-arm randomized controlled trial will evaluate clinical efficacy of music exercise therapy in improving the freezing of gait in Parkinson’s patients. We will recruit a total of 81 inpatients with Parkinson’s disease, who meet the trial criteria. The patients will randomly receive music exercise with and without music as well as routine rehabilitation therapies, followed by analysis of changes in their gait and limb motor function after 4 weeks of intervention. We will first use a three-dimensional gait analysis system to evaluate changes in patients’ gait, followed by assessment of their limb function, activity of daily living and fall risk. Discussion The findings of this trial are expected to affirm the clinical application of this therapy for future management of the disease. Trial registration Chinese Clinical Trial Registry ChiCTR1900026063. Registered on September 20, 2019

Los Efectos De La Práctica De Ejercicio Físico en La Prevención De Caídas en Pacientes Con Enfermedad De Parkinson. Una Revisión Integradora De La Literatura Científica

“…La terapia de ejercicios musicales genera cambios en parámetros clínicos y cinemáticos (25). Por este motivo, muestran una mejora en la congelación de la marcha, lo que reduce las caídas (17,41). El Tai Chi es favorable como terapia complementaria, considerando que las caídas disminuyen en efecto a la disminución de los síntomas de EP (30,40,43).…”

Musicokinetic and exercise therapies decrease the depression level of elderly patients undergoing post-stroke rehabilitation: The moderating effect of health regulatory focus

“…The musicokinetic therapy is developed by Noda et al (2003) , in which the trampoline with live music performance is employed to improve the clinical condition of patients in a persistent vegetative state. It has been found that under the musicokinetic therapy treatment, patients’ psychological and physiological activities can be changed by listening to music while exercising ( Noda et al, 2003 ; Li et al, 2021 ). It has both cognitive and behavioral effects on the treatment of brain damage ( Noda et al, 2004 ; Van de Winckel et al, 2004 ; Magee, 2005 ).…”