Possible therapeutic effects of<i>Crocus sativus</i>stigma and its petal flavonoid, kaempferol, on respiratory disorders

Kianmehr, Majid; Khazdair, Mohammad Reza

doi:10.1080/13880209.2020.1844762

Cited by 16 publications

(14 citation statements)

References 63 publications

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“…ex Colebr., antibacterial, antifungal, anti-inflammatory, antioxidant, antimicrobial, asthma, skin wounds, sedative [114][115][116]; Bryonia spp., anti-inflammatory [117]; Carum carvi L., diuretic, dyspepsia, emmenagogue, gastrointestinal disorders [118,119]; Capparis spinosa L., antimicrobial, anti-inflammatory, hepatoprotector (aerial parts), hypocholesterolemic (fruit), hypoglycaemic (fruit), hypolipidemic (fruit) [120][121][122]; Centaurium erythraea Rafn., antipyretic, hepatoprotector [123,124]; Centaurea benedicta (L.) L., antischistosomiasis, wounds, antiulcer [125,126]; Ceterach officinarum Willd., antioxidant [127,128]; Cichorium endivia L., antioxidant (hypogeal parts), hepatoprotector [129,130]; Citrus medica L., antibacterial [131]; Cinnamomum camphora (L.) J. Presl, antifungal, anti-inflammatory, antiparasitic [132][133][134]; Cinnamomum verum J. Presl, airways, gastrointestinal disorders, strengthens the nervous system [135][136][137]; Citrullus colocynthis (L.) Schrad., anti-inflammatory [138]; Commiphora gileadensis (L.) C. Chr., antibacterial [139]; Commiphora myrrha (Nees) Engl., antibacterial, antifungal, anti-inflammatory, antioxidant, antiseptic, antihistamine, di-gestive, emmenagogue, stimulates the urinary tract, gingivitis, airways [140][141][142]; Crocus spp., gastrointestinal disorders, airways, sedative [143][144][145][146]; Cucumis melo L., antiinflammatory [147]; Cuminum cynumum L., emmenagogue, gastrointestinal disorders [118]; Curcuma longa L., gastrointest...…”

Section: Category Of Pathologymentioning

confidence: 99%

Ca’ Granda, Hortus simplicium: Restoring an Ancient Medicinal Garden of XV–XIX Century in Milan (Italy)

et al. 2021

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This work is based on the study of 150 majolica vases dated back to the mid XVII century that once preserved medicinal remedies prepared in the ancient Pharmacy annexed to the Ospedale Maggiore Ca’ Granda in Milan (Lombardy, Italy). The Hortus simplicium was created in 1641 as a source of plant-based ingredients for those remedies. The main objective of the present work is to lay the knowledge base for the restoration of the ancient Garden for educational and informative purposes. Therefore, the following complementary phases were carried out: (i) the analysis of the inscriptions on the jars, along with the survey on historical medical texts, allowing for the positive identification of the plant ingredients of the remedies and their ancient use as medicines; (ii) the bibliographic research in modern pharmacological literature in order to validate or refute the historical uses; (iii) the realization of the checklist of plants potentially present in cultivation at the ancient Garden, concurrently with the comparison with the results of a previous in situ archaeobotanical study concerning pollen grains. For the species selection, considerations were made also regarding drug amounts in the remedies and pedoclimatic conditions of the study area. Out of the 150 vases, 108 contained plant-based remedies, corresponding to 148 taxa. The remedies mainly treated gastrointestinal and respiratory disorders. At least one of the medicinal uses was validated in scientific literature for 112 out of the 148 examined species. Finally, a checklist of 40 taxa, presumably hosted in the Hortus simplicium, was assembled.

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Section: Category Of Pathologymentioning

confidence: 99%

Ca’ Granda, Hortus simplicium: Restoring an Ancient Medicinal Garden of XV–XIX Century in Milan (Italy)

et al. 2021

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“…e antimicrobial effects of protocatechuic, p-coumaric, ferulic acids, catechol [7], and kaempferol [39] were also reported. Kaempferol also showed detoxifying, apoptotic, antineoplastic [75], anti-inflammatory, and antioxidant activities [76,77]. e sulfur compounds possess antibacterial, antifungal, antitumor, and antilarval effects [78].…”

Section: Traditional and Pharmacological Effectsmentioning

confidence: 99%

Effects of Allium cepa and Its Constituents on Respiratory and Allergic Disorders: A Comprehensive Review of Experimental and Clinical Evidence

Beigoli

Behrouz

Memarzia

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The health benefits of Allium cepa (A. cepa) have been proclaimed for centuries. Various pharmacological and therapeutic effects on respiratory, allergic, and immunologic disorders are shown by A. cepa and its constituents. Flavonoids such as quercetin and kaempferol, alk(en)yl cysteine sulfoxides including S-methyl cysteine sulfoxide and S-propyl cysteine sulfoxide, cycloalliin, thiosulfinates, and sulfides are the main compounds of the plant. A. cepa displays broad-spectrum pharmacological activities including antioxidant, anti-inflammatory, antihypertensive, and antidiabetic effects. Our objective in this review is to present the effects of A. cepa and its constituents on respiratory, allergic, and immunologic disorders. Different online databases were searched to find articles related to the effect of A. cepa extracts and its constituents on respiratory, allergic, and immunologic disorders until the end of December 2020 using keywords such as onion, A. cepa, constituents of A. cepa, therapeutic effects and pharmacological effects, and respiratory, allergic, and immunologic disorders. Extracts and constituents of A. cepa showed tracheal smooth muscle relaxant effects, indicating possible bronchodilator activities or relieving effects on obstructive respiratory diseases. In experimental animal models of different respiratory diseases, the preventive effect of various extracts and constituents of A. cepa was induced by their antioxidant, immunomodulatory, and anti-inflammatory effects. The preventive effects of the plant and its components on lung disorders induced by exposure to noxious agents as well as lung cancer, lung infection, and allergic and immunologic disorders were also indicated in the experimental and clinical studies. Therefore, this review may be considered a scientific basis for development of therapies using this plant, to improve respiratory, allergic, and immunologic disorders.

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“…by immune effector cells [4,5]. Various biological compounds such as of flavonoids, have been showed as anti-asthmatic [6,7], therapeutic, antioxidant, antiviral and with other properties in nature [8,9]. Anti-SARS coronavirus 3C-like protease effects of plant-derived phenolic compounds were also reported [10].…”

Section: To the Editormentioning

confidence: 99%

Potential Effects of A Flavonoid, Hesperidin on SARS-CoV-2 Disease

Khazdair

2021

Advances in Respiratory Medicine

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Possible therapeutic effects ofCrocus sativusstigma and its petal flavonoid, kaempferol, on respiratory disorders

Cited by 16 publications

References 63 publications

Ca’ Granda, Hortus simplicium: Restoring an Ancient Medicinal Garden of XV–XIX Century in Milan (Italy)

Ca’ Granda, Hortus simplicium: Restoring an Ancient Medicinal Garden of XV–XIX Century in Milan (Italy)

Effects of Allium cepa and Its Constituents on Respiratory and Allergic Disorders: A Comprehensive Review of Experimental and Clinical Evidence

Potential Effects of A Flavonoid, Hesperidin on SARS-CoV-2 Disease

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