Possible Source of Secondary Invading Staphylococci in Mice Exposed to Acute Cold

Abstract

MIRAGLIA, GENNARO J.

The Influence of Cold on Mortality from Streptococci Following Ozone Exposure

“…Ozone was monitored at 15-minute intervals by the neutral potassium iodide procedure. 7 An attempt was made to maintain a concentration of 0.7 to 0.9 ppm, but it was difficult to prevent brief higher concentration spikes by the methods used.…”

“…6 Germane to this paper is the observation that cold enhances mortality to bacterial infections. 7 In view of the foregoing, exposure to cold temperature has been incorporated as a supplementary stress in the model system employing ozone as the primary stressful treatment and aerosolized bacteria as the secondary stress or indicator system. 5 Preliminary information from a study employing cold stress, ozone exposure, and streptococcus in that order is given herein.…”

Immunological Consequences of Changing Environmental Stimuli

“…An excellent example of this concept was provided in the early 1960s (Table 2). Cold exposure increased the severity of secondary staphylococcal infections and increased the susceptibility of mice to avirulent Staphylococcus aureus and Salmonella typhimurium (88,89,93), but cold air had little effect on mortality when virulent organisms were inoculated into mice.…”