Possible role of trauma as a cocarcinogen. Case report on an oil worker

Beyond foreign‐body‐induced carcinogenesis: Impact of reactive oxygen species derived from inflammatory cells in tumorigenic conversion and tumor progression

“…54,55 Trauma is considered not to act as initiator, but to act as promoter of carcinogenesis. 56 Fibrosis associated with tumor growth provides the environment to stimulate progression of tumor cells. Most of the clinical local recurrences of gastrointestinal tumors after resection of the primary tumor occur at the operated area of incision or anastomosis.…”

Pke-Cancer and the Skin

“…Everybody is daily exposed to minor injury, and post hoc reasoning may subsequently link unrelated events, especially if a compensation case is involved. Yet, in industry at least, trauma seems to have a co-carcinogenic effect (68,132), and a neoplasm has even been attributed to a single injury (279). In the discussion of the legal process arising out of this case, one witness said that 2% of all sarcomata could be attributed to injury, while in a survey of squamous epitheliomata, trauma seemed significant (33).…”

“…Dithranol has simite potential (256,282) and related compounds react with nucleic acids in the skin (31). Tars and their distillation products provide serious occupational hazards for many classes of industrial worker (68,90,109,132). Prolonged exposure is important, as the latent period for the appearance of cancers of the skin has a peak after 20 years (109).…”

“…Prolonged exposure is important, as the latent period for the appearance of cancers of the skin has a peak after 20 years (109). It is likely that many cases also reflect the effects of trauma (68,132), and recurrent injury and infection are important. The exfoliation which is such a feature of the increased epithelial activity in psoriasis, probably protects the patient from both infections and neoplasms.…”