Beyond foreign‐body‐induced carcinogenesis: Impact of reactive oxygen species derived from inflammatory cells in tumorigenic conversion and tumor progression

Okada, Futoshi

doi:10.1002/ijc.23125

Cited by 70 publications

(74 citation statements)

References 92 publications

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“…Although fiber dimensions, biopersistence, oxidative stress and inflammation have all been implicated, (7)(8)(9)(10)(11)(12) the exact mechanisms of pleural pathogenesis are unclear. According to a pathogenesis paradigm suggested by Donaldson et al,…”

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confidence: 99%

“…(1)(2)(3)(4)(5)(6) Pleural plaque and malignant mesothelioma are characteristic lesions in asbestos-exposed humans. Although fiber dimensions, biopersistence, oxidative stress and inflammation have all been implicated, (7)(8)(9)(10)(11)(12) the exact mechanisms of pleural pathogenesis are unclear. According to a pathogenesis paradigm suggested by Donaldson et al, (2) asbestos fibers penetrate into the pleural cavity from the alveoli and deposit in the pleural tissue.…”

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confidence: 99%

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Multi‐walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats

et al. 2012

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Multi-walled carbon nanotubes have a fibrous structure similar to asbestos and induce mesothelioma when injected into the peritoneal cavity. In the present study, we investigated whether carbon nanotubes administered into the lung through the trachea induce mesothelial lesions. Male F344 rats were treated with 0.5 mL of 500 lg/mL suspensions of multi-walled carbon nanotubes or crocidolite five times over a 9-day period by intrapulmonary spraying. Pleural cavity lavage fluid, lung and chest wall were then collected. Multi-walled carbon nanotubes and crocidolite were found mainly in alveolar macrophages and mediastinal lymph nodes. Importantly, the fibers were also found in the cell pellets of the pleural cavity lavage, mostly in macrophages. Both multi-walled carbon nanotube and crocidolite treatment induced hyperplastic proliferative lesions of the visceral mesothelium, with their proliferating cell nuclear antigen indices approximately 10-fold that of the vehicle control. The hyperplastic lesions were associated with inflammatory cell infiltration and inflammationinduced fibrotic lesions of the pleural tissues. The fibers were not found in the mesothelial proliferative lesions themselves. In the pleural cavity, abundant inflammatory cell infiltration, mainly composed of macrophages, was observed. Conditioned cell culture media of macrophages treated with multi-walled carbon nanotubes and crocidolite and the supernatants of pleural cavity lavage fluid from the dosed rats increased mesothelial cell proliferation in vitro, suggesting that mesothelial proliferative lesions were induced by inflammatory events in the lung and pleural cavity and likely mediated by macrophages. In conclusion, intrapulmonary administration of multi-walled carbon nanotubes, like asbestos, induced mesothelial proliferation potentially associated with mesothelioma development. (Cancer Sci 2012; 103: 2045-2050 M ulti-walled carbon nanotubes (MWCNT) are structurally composed of cylinders rolled up from several layers of graphite sheets. They are several to tens of nanometers in diameter and several to tens of micrometers in length. This high length to diameter aspect ratio, a characteristic shared with asbestos fibers, has led to concern that exposure to MWCNT might cause asbestos-like lung diseases, such as lung fibrosis, lung cancer, pleural plaque and malignant mesothelioma.(1-6) Pleural plaque and malignant mesothelioma are characteristic lesions in asbestos-exposed humans. Although fiber dimensions, biopersistence, oxidative stress and inflammation have all been implicated, (7)(8)(9)(10)(11)(12) the exact mechanisms of pleural pathogenesis are unclear. According to a pathogenesis paradigm suggested by Donaldson et al.,asbestos fibers penetrate into the pleural cavity from the alveoli and deposit in the pleural tissue. Unlike spherical particles, fibrous materials such as asbestos are not cleared effectively from the pleural cavity, resulting in deposition of the fibers in the parietal pleura. This deposition, in turn, causes frustrated ...

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Multi‐walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats

et al. 2012

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“…Rajkovi, et al described a case of gossypiboma discovered 40 years after index surgery as the cause for chronic lumbar back pain [6]. As a consequence of the inflammatory process introduced by retained surgical bodies, sarcomas developing from chronic inflammatory tissue have been reported throughout the literature [10][11][12]. In the presented case, the exudative process led to migration of surgical gauze to the distal medial thigh over a period of 15 years.…”

Section: Discussionmentioning

confidence: 74%

Retained Surgical Gauze Swab Migration in a Paraplegic Patient: A Case Report and Literature Review

Vogel¹,

Rudin²,

Ladurner³

2017

J Clin Case Rep

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Introduction: Gossypiboma is a serious but uncommon complication of surgical interventions. Most case reports and reviews refer to abdominal or thoracic surgery. Retained postoperative foreign bodies in limb or spine surgery are less commonly encountered. We present a case of gossypiboma in a paraplegic patient originating from pararectal surgery and detected 15 years after index surgery for infectious migration to the left thigh.

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“…36 Tumor development is said to depend on the host's immunological reaction and its derived intermediate reactive substances to the foreign bodies. 35 We have revealed that ROS are commonly formed in QR-32 cells after co-culture with either hydrophilic or hydrophobic nano-TiO 2 . ROS generation by TiO 2 is a well-known phenomenon 37 and the feature has been used for antibacterial activity against both Gram-negative and -positive bacteria.…”

Section: Discussionmentioning

confidence: 92%

“…The influence of material's hydropathy has been pointed out in foreign-body-induced carcinogenesis, which may be fundamentally same in fine particle-related carcinogenesis. 35 In experimental foreign body-induced carcinogenesis, subcutaneous implantation of hydrophobic membranes in mice develops more autologous tumors than those obtained with hydrophilic ones. 36 Tumor development is said to depend on the host's immunological reaction and its derived intermediate reactive substances to the foreign bodies.…”

Section: Discussionmentioning

confidence: 99%

Nano-Scaled Particles of Titanium Dioxide Convert Benign Mouse Fibrosarcoma Cells into Aggressive Tumor Cells

Onuma

Sato

Ogawara

et al. 2009

The American Journal of Pathology

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Nanoparticles are prevalent in both commercial and medicinal products; however, the contribution of nanomaterials to carcinogenesis remains unclear. We therefore examined the effects of nano-sized titanium dioxide (TiO 2 ) on poorly tumorigenic and nonmetastatic QR-32 fibrosarcoma cells. We found that mice that were cotransplanted subcutaneously with QR-32 cells and nano-sized TiO 2 , either uncoated (TiO 2 ؊1, hydrophilic) or coated with stearic acid (TiO 2 ؊2, hydrophobic), did not form tumors. However, QR-32 cells became tumorigenic after injection into sites previously implanted with TiO 2 ؊1, but not TiO 2 ؊2, and these developing tumors acquired metastatic phenotypes. No differences were observed either histologically or in inflammatory cytokine mRNA expression between TiO 2 ؊1 and TiO 2 ؊2 treatments. However, TiO 2 ؊2, but not TiO 2 ؊1, generated high levels of reactive oxygen species (ROS) in cell-free conditions. Although both TiO 2 ؊1 and TiO 2 ؊2 resulted in intracellular ROS formation, TiO 2 ؊2 elicited a stronger response, resulting in cytotoxicity to the QR-32 cells.

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Beyond foreign‐body‐induced carcinogenesis: Impact of reactive oxygen species derived from inflammatory cells in tumorigenic conversion and tumor progression

Cited by 70 publications

References 92 publications

Multi‐walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats

Multi‐walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats

Retained Surgical Gauze Swab Migration in a Paraplegic Patient: A Case Report and Literature Review

Nano-Scaled Particles of Titanium Dioxide Convert Benign Mouse Fibrosarcoma Cells into Aggressive Tumor Cells

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