Possible Role of CD11a in Primary Immune Thrombocytopenia Patients on Immunosuppressive Therapy

Abstract

Background and Objectives Immune thrombocytopenia (ITP) is one of the autoimmune diseases that presented by thrombocytopenia and increased risk of bleeding. Etiology of immune thrombocytopenia (ITP) is very complex. Lymphocyte function associated antigen-1 (LFA-1) plays important role in ITP. The aim of this study was evaluation of expression of CD11a on lymphocytes to explore its possible role in primary ITP patients also, regarding severity and response to immunosuppressive treatment. Patients and Methods This is a cross-sectional case-control study. Forty adult patients aged (18:58) years, 29 females and 11 males were enrolled as newly diagnosed primary ITP. Forty age and sex matched control subjects were randomly selected. The expression of CD11a on lymphocyte subpopulations (CD3+ T cells, CD3+CD4+ T cells and CD19+ B cells) was analyzed by flowcytometry at the start of the study and after 6 months of follow-up. Results The mean fluorescence intensity (MFI) of CD11a on CD3+ T and CD19+ B lymphocytes was significantly highly increased in ITP patients compared to healthy controls while MFI of CD11a on CD3+ CD4+Tclls was non-significant. MFI of CD11a on CD3+ and CD19+ B lymphocytes showed non-significant elevation with platelet count or bleeding score. MFI of CD11a on CD3+ showed significant highly increased level in refractory ITP compared with responder cases. Conclusion CD11a had possible role in the pathogenesis of ITP. Immunosuppressive therapy in ITP did not affect the level of CD11a expression on T and B lymphocytes. Levels of CD11a do not reflect the severity of ITP neither platelet count nor bleeding score. Increased MFI of CD11a in CD3+T lymphocytes of ITP patients may cause resistance to immunosuppressive therapy.

Monkeypox Disease with Predominant Genital Symptoms: A Nigerian Case Report

“…In this patient, the phallus was found to be massively swollen and slightly tender with two deep-seated solitary ulcerative lesions on the glans penis and another at shaft of the penis. Single solitary lesions were hitherto not common presentations of Mpox disease and can be misdiagnosed for Syphilis, Lymphogranuloma Venerium, or even Chancroid [17]. In this case, it was misdiagnosed and managed as a case of secondary syphilis.…”

“…For this case, apart from a two-week history of undisclosed sexual contact, there was no history of contact with a suspected or confirmed Mpox case suggesting that there was no epidemiological linkage. But studies suggest the possibility of asymptomatic or pauci-symptomatic transmission of the disease [17,21]. The patient was reluctant to provide the details of the casual sexual contact for contact tracing even though the State Public Health Law Cap 106 laws of Rivers State 1999, require the mandatory disclosure of all necessary health information to the health care provider that would be useful for the containment of infectious diseases.…”

Variation of Biological and Biochemical Parameters in Patients Receiving Antiretroviral Treatment at the Maradi Regional Hospital during 2021-2022

“…CD11a is important for normal lymphocyte development [1]. HIV activates CD4+ T lymphocytes, dendritic cells, and macrophages, resulting in immune system dysfunction [2].…”

Red cell distribution width is an inflammatory predictor marker of contrast induced nephropathy in patients undergoing percutaneous coronary intervention

“…Also, ICAM-1 plays a role in the pathogenesis of immune thrombocytopenia (ITP). 18 Contrast-induced nephropathy (CIN) is an important complication of invasive cardiovascular procedures. Patients who undergo percutaneous coronary intervention (PCI) are at greater risk of CIN and patients with diabetes mellitus or baseline renal impairment have a risk of almost 50%.…”