Possible role of ABO system in age-related diseases and longevity: a narrative review

Abstract

ABO blood group antigens are expressed either on the surface of red blood cells either on a variety of other cells. Based on the available knowledge of the genes involved in their biosynthesis and their tissue distribution, their polymorphism has been suggested to provide intraspecies diversity allowing to cope with diverse and rapidly evolving pathogens. Accordingly, the different prevalence of ABO group genotypes among the populations has been demonstrated to be driven by malaria selection. In the similar manner, a particular ABO blood group may contribute to favour life-extension via biological mechanisms important for surviving or eluding serious disease. In this review, we will suggest the possible association of ABO group with age-related diseases and longevity taking into account the biological role of the ABO glycosyltransferases on some inflammatory mediators as adhesion molecules.

Relationship between the AB0 Blood System and Proximal Femoral Fracture Patterns in the Turkish Population

“…On the other hand, hereditary factors have been implicated among the factors affecting fracture patterns, including AB0 genes. The AB0 blood system, which is the most commonly used system Recently, the AB0 system has been associated with several diseases such as cardiovascular disease and pancreatic and gastric cancers [9]. It has been reported that the risk of squamous cell carcinoma was reduced by 14% and the risk of basal cell carcinoma by 5% in persons with a non-0 (A, B, and AB) blood group compared to individuals with a 0 blood group [14].…”

“…Thorsoe underlined the possible role of AB0 blood groups in the 1960s [8]. Several studies have associated blood groups with ageing [9]. In recent years, AB0 antigens have been associated with cerebrovascular and cardiovascular diseases, visceral neoplasia, and infections [10].…”

Значення генетичних систем AB0, Rh та Hp у стрес-індукованій імунореактивності мешканців територій, забруднених радіонуклідами

“…Можливо, реалізація відбувається на рівні міжрецепторних взаємодій, коли макрофаги відіграють роль антигенпрезентації для Т-лімфоцитів [4]. Крім того, у джерелах літератури вказується, що присутність еритроцитарних антигенів на плазмолемі імунокомпетентних клітин, на певних стадіях їхнього тимічного розвитку сприяє диференціюванню й формуванню зрілого фенотипу [13]. Ця гіпотеза підтверджується тим, що висока варіативність реагування простежена саме для тимусозалежних клітин, а зміни кількості субпопуляції природних кілерів із фенотипом CD16+ практично не залежали від фенотипу генетичних систем крові.…”

Evolutionary aspects of ABO blood group in humans

“…However, despite the fact that ABO antigens have been known for more than a century, their biological significance remains largely elusive. Therefore, the aim of this narrative review is to summarize the current knowledge on the clinical significance of the ABO Clinica Chimica Acta 444 (2015) [66][67][68][69][70][71] system, providing a tentative interpretation of the available literature data according to an evolutionary perspective.…”