Possible relationship between chronic telogen effluvium and changes in lead, cadmium, zinc, and iron total blood levels in females: A case-control study

Abstract

Introduction:Hair loss is a common and distressing problem that can affect both males and females of all ages. Chronic telogen effluvium (CTE) is idiopathic diffuse scalp hair shedding of at least 6 months duration. Hair loss can be one of the symptoms of metal toxicity. Lead (Pb) and cadmium (Cd) are highly toxic metals that can cause acute and chronic health problems in human. The aim of the present study is to determine if there is a relationship between these metals and CTE in women and if CTE is also associated with changes in zinc (Zn) or iron (Fe) blood levels.Materials and Methods:Pb, Cd, Fe and Zn total blood levels were determined in 40 female patients fulfilling the criteria of CTH and compared with total blood levels of same elements in 30 well-matched healthy women.Results:Quantitative analysis of total blood Fe, Zn, Pb and Cd revealed that there were no significant differences between patients and controls regarding Fe, Zn, and Pb. Yet, Cd level was significantly higher in patients than controls. In addition, Cd level showed significant positive correlation with the patient's body weight.Conclusion:Estimation of blood Pb and Cd levels can be important in cases of CTE as Cd toxicity can be the underlying hidden cause of such idiopathic condition.

Evaluation of the levels of trace elements in the blood and hair of female patients with chronic telogen effluvium

“…These cells may exhibit a fine sensitivity to even a small decrease in the amount of iron in the body [22]. Similar to this study, serum iron levels did not differ significantly in some studies in patients with telogen effluvium [23,24]. Another study associated reduced ferritin levels with hair loss without an established iron deficiency [22].…”

Assessment of heavy metal and trace element levels in patients with telogen effluvium

“…patients had significantly higher cadmium levels than controls. [ 21 ] Similarly, our patients had significant elevation in cadmium compared to controls. This may be due to high prevalence of smoking in our geographical location.…”

Evaluation of Serum Iron, Ferritin, Zinc and Folic Acid Levels in Female Patients with Diffuse Hair Loss

“…Bu bağlamda, idiyopatik saç dökülmelerinde olası bir ağır metal birikimi düşünülerek çinko tedavisi verilebilir. 20 Literatürde, folik asit eksikliği ile diffüz saç dökülmesini ilişkilendiren çok az sayıda çalışma vardır. Özden ve ark., saç dökülmesi olan 100 kadın hastanın sadece 1'inde folat eksikliği tespit etmişlerdir.…”