Possible Prophylaxes of Aloe Vera Gel Ingestion to Butyrate Metabolism

Abstract

There is a growing interest in butyrate because its impact on epigenetic mechanisms will lead to more specific and efficacious therapeutic strategies for the presentation and treatment of different disease ranging from genetic/metabolic conditions to neurological degeneration disorders. The dietary natural source of butyrate through a high fiber diet or butyrate produced by fermentation of non-digestive fiber, such as acemannan in Aloe Vera leaf gel, is a highly appealing approach to present a simple and relatively low risk method to potentially improve outcomes in aged people with brain troubles. In this review, we will discuss the pharmacological effects of butyrate as a histone deacetylase inhibitor to an insulin resistance and energy expenditure, and as pro-drugs to ulcerative colitis and cancer, and the gut-liver axis in pre-clinical treatment.

Dietary Cancer Prevention with Butyrate Fermented by Aloe vera Gel Endophytic Microbiota

“…In an early our in vitro study, the fermentation production of butyric acid was confirmed by endophytic bacteria within Aloe vera gel [15] and possible prophylaxes of Aloe vera gel ingestion to butyrate metabolism was suggested [16] . Present investigation shows the identification of Bacillus cereus, B.licheniformis, Lactobacillus paralimentarium and Clavispora lusitaniae by use of MALDI-TOF/MS, a rapid, reliable and costdeacetylases (HDACs).…”

Dietary ALoe vera gel and Microbiota Interactions: Influence of Butyrate and Insulin Sensitivity

“…Possible efficacy of longterm ingestion of Aloe vera gel metabolites on insulin sensitivity has been proposed by Yagi A [1] , and the brain-liver-intestine circuit was considered for coordination between insulin sensitivity and glucose production. On exploration of health maintenance with Aloe vera gel long-term ingestion, Yagi A group [2] proposed that the dietary natural source of butyrate produced by fermentation of acemannan in Aloe vera gel, is a highly appealing approach to present a simple and relatively low risk method to potentially improve outcomes in aged people with brain troubles. Krautkramer KA group [3] demonstrated that gut microbiota alter host histone acetylation and methylation in the multiple host tissues; the proximal colon, the liver and fat tissue.…”

Gut Microbiota: Influence of Aloe vera gel and Calorie Restriction

“…The dietary natural source of butyrate through a high fiber diet or butyrate produced by fermentation of non-digestive fiber, such as acemannan in Aloe vera gel, is highly appealing approach to present a simple and selectively lower risk method to potentiate the improved outcomes in aged people with brain dysfunctions. Recently, Yagi et al [21] discussed the potential pharmacological effect of butyrate as a histone deacetylase inhibitor on insulin resistance and energy expenditure, and as prodrugs for ulcerative colitis and cancer, and the gut-liver axis in preclinical treatment.…”