Possible participation of acidic pH in bone resorption in middle ear cholesteatoma

Nguyen, Khac‐Hung; Suzuki, Hideaki; Ohbuchi, Toyoaki; Wakasugi, Tetsuro; Koizumi, Hiroki; Hashida, Koichi; Baba, Ryoko; Morimoto, Hiroyuki; Doi, Yoshiaki

doi:10.1002/lary.23883

Cited by 18 publications

(26 citation statements)

References 41 publications

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“…Areas of bone destruction could be seen at the site of rupture of cholesteatoma [54,55]. Hydroxyapatite, an inorganic bone component is highly insoluble under physiologic pH environment, but solubility dramatically increases as the pH is lowered [56].…”

Section: Mechanisms Of Bone Resorption In Cholesteatomamentioning

confidence: 99%

“…Hydroxyapatite, an inorganic bone component is highly insoluble under physiologic pH environment, but solubility dramatically increases as the pH is lowered [56]. Nguyen et al [55] investigated the role of pH in bone resorption in cholesteatoma and found that the pH of keratin debris was acidic and lower than the antrum mucosa. So, they concluded that acidic pH in cholesteatoma may be one of the factors that promote bone erosion by decalcification of the adjacent bony structures [55].…”

Section: Mechanisms Of Bone Resorption In Cholesteatomamentioning

confidence: 99%

“…Nguyen et al [55] investigated the role of pH in bone resorption in cholesteatoma and found that the pH of keratin debris was acidic and lower than the antrum mucosa. So, they concluded that acidic pH in cholesteatoma may be one of the factors that promote bone erosion by decalcification of the adjacent bony structures [55]. …”

Section: Mechanisms Of Bone Resorption In Cholesteatomamentioning

confidence: 99%

See 2 more Smart Citations

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Hamed

Nakata

Sayed

et al. 2016

Clin Exp Otorhinolaryngol

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Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords ‘aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines.’ In order to strengthen our study, we searched the reference lists of identified reviews. Cholesteatoma is a subject of debate among otolaryngologists since it was prescribed firstly. Over many decades, several theories were postulated for aetiopathogenesis of cholesteatoma with a tendency to follow more than one theory to explain the proper nature of that disease. Until now, the mechanism of bone resorption has yet to be more clarified. In the last century, a leap has occurred in the field of biomolecular cholesteatoma research which improved our knowledge about its pathophysiology and bone destructive mechanism. However, surgery is still the only available treatment. We conclude that discovery of new therapeutic choices for cholesteatoma other than surgery by the use of anti-growth, anti-proliferative, apoptotic agents as well as medications that antagonize osteoclastogenesis should be the main concern in the future clinical and experimental research work. Also, searching for predictors of the aggressiveness of cholesteatoma can affect the timing of intervention and prevent occurrence of complications.

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Section: Mechanisms Of Bone Resorption In Cholesteatomamentioning

confidence: 99%

Section: Mechanisms Of Bone Resorption In Cholesteatomamentioning

confidence: 99%

Section: Mechanisms Of Bone Resorption In Cholesteatomamentioning

confidence: 99%

See 1 more Smart Citation

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Hamed

Nakata

Sayed

et al. 2016

Clin Exp Otorhinolaryngol

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“…It may be a birth defect (congenital cholesteatoma) or acquired cholesteatoma, which is most commonly associated with repeated middle ear chronic inflammation caused by bacteria or viruses [2,3]. …”

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High-Prevalence of Various High-Risk Sub-types of Human Papilloma Virus in Patients with Acquired Cholesteatoma in Greece

Skoulakis¹,

Lachanas²,

Florou³

et al. 2018

acta scient microb

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Cholesteatoma is an abnormal, noncancerous skin growth tumor, that can develop in the middle section of the ear, behind the eardrum [1]. It may be a birth defect (congenital cholesteatoma) or acquired cholesteatoma, which is most commonly associated with repeated middle ear chronic inflammation caused by bacteria or viruses [2,3]. AbstractKeywords: HPV; sub-types acquired holesteatoma; Greece Although there are a lot of theories, the pathogenesis of cholesteatoma remains unclear. Few studies exist worldwide regarding the presence of Human Papilloma Virus (HPV) in cholesteatoma with controversial results. The presence of DNA of various high and low risk HPV sub-types was detected by real-time PCR to lesions obtained from sixty-two patients with acquired cholesteatoma. In addition, the presence of bacterial DNA was also detected using 16S rRNA PCR. Control group included tympanic membrane skin samples from patients operated by tympanoplasty. Cholesteatoma samples of thirty patients (48.3%) were found to be positive for one at least HPV sub-type. Twenty-five samples were positive for HPV16 (40.3%), nine were positive for HPV6 (14.5%), one for HPV18 (1.6%), one for HPV31 (1.6%), one for HPV51 (1.6%) and one for HPV59 (1.6%). None of the patients of control group was found to be positive for any sub-type HPV (0%). On the other hand, all specimens (cholesteatoma and tympanic membrane skin mucosa) were negative for the presence of bacterial DNA. Our results demonstrate a high prevalence of various high and low-risk HPV sub-types in cholesteatoma tissue samples in Central Greece.

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“…Until the middle period of the 20th century, the pressure necrosis theory was believed to explain this phenomenon. Since the 1970s, a number of inflammatory substances, such as interleukin‐1 α , tumour necrosis factor‐ α , interleukin‐6, macrophage colony‐stimulating factor and prostaglandin E2, have been detected in cholesteatoma tissue, and have been presumed to be responsible for bone resorption in this disease . In the 2000s, the mainstream theory posited that the bone resorption mechanism involves osteoclast activation induced by various inflammatory mediators.…”

mentioning

confidence: 99%

Expressions of isopeptide bonds and corneodesmosin in middle ear cholesteatoma

Koizumi

Kawaguchi

Ohkubo

et al. 2016

Clinical Otolaryngology

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Possible participation of acidic pH in bone resorption in middle ear cholesteatoma

Abstract: These results indicate that acid leakage through the cholesteatoma epithelium probably participates in the resorption of the underlying bone structure. The increased permeability of the cholesteatoma epithelium may be explained by a decrease in filaggrin expression.

Cited by 18 publications

References 41 publications

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

High-Prevalence of Various High-Risk Sub-types of Human Papilloma Virus in Patients with Acquired Cholesteatoma in Greece

Expressions of isopeptide bonds and corneodesmosin in middle ear cholesteatoma

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