Biomarkers of otorhinolaryngologic diseases with higher insult over aperson’s him/herself and overall health services are summarized in brief. In order todefine, diagnose, treat and monitor any disease markers are needed.Otorhinolaryngology (ORL) is interested in special disease entities of the regionbesides otorhinolaryngologic involvements of the systemic diseases and unique formsof pathologies such as cholesteatoma, Meniere’s disease and otosclerosis. Neoplasia isanother heading to deal with. In the following chapter, one will find an overview ofmolecules that have been used as a biomarker as well as the end points of the presentresearch on the issue relevant with ORL. Day by day, new molecules are being namedhowever, the pathways of action are rather the same. Readers will find the headingsrelated to the most common diseases of the field, informing them about where to lookfor defining new strategies of understanding of each disease.