Possible Parkinson's Disease Induced by Chronic Manganese Supplement Ingestion

Schuh, Michael J.

doi:10.4140/tcp.n.2016.698

Cited by 12 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…of Mn are associated with increased inflammatory markers in elderly men [115]. Chronic consumption of dietary supplements containing excessive levels of Mn has led to the development of Parkinson's Disease, CNS disturbances, and dementia in adults [116][117][118].…”

Section: The Toxicity Of Manganese By Ingestion Exposurementioning

confidence: 99%

Estimating daily intakes of manganese due to breast milk, infant formulas, or young child nutritional beverages in the United States and France: Comparison to sufficiency and toxicity thresholds

Mitchell¹,

Frisbie

Roudeau

et al. 2020

Preprint

View full text Add to dashboard Cite

Laboratories provided no input in choosing the subject matter of this project, the hypotheses that were tested, the method of analysis, the research findings, the decision to publish, or the manner of disseminating the results. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Highlights1. Mn deficiency is unlikely with exclusive breast milk or infant formula feeding.2. Breast milk Mn mean intake is 1.2 µg/kg/day (3 weeks)-0.16 µg/kg/day (18 months).3. Formula Mn intake range is 130 µg/kg/day (3 weeks)-4.8 µg/kg/day (18 months). 4. Formula products reconstituted with 250 µg Mn/L water may exceed 140 µg Mn/kg/day. 5. Formula products may surpass regulatory tolerable daily intake levels for Mn. Abstract BackgroundAlthough manganese (Mn) is an essential nutrient, recent research has revealed that excess Mn in early childhood may have adverse effects on neurodevelopment. MethodsWe estimated daily total Mn intake due to breast milk at average body weights by reviewing reported concentrations of breast milk Mn and measurements of body weight and breast milk intake at 3 weeks, 4.25 months, 7 months, and 18 months. We compared these figures to the Mn content measured in 44 infant, follow-up, and toddler formulas purchased in the United States and France. We calculated Mn content of formula products made with ultra-trace elemental analysis grade water (0 µg Mn/L) and with water containing 250 µg Mn/L, a concentration which is relatively high but less than the World Health Organization Health-based value of 400 µg Mn/L or the United States Environmental Protection Agency Health Advisory of 350 µg Mn/L. ResultsEstimated mean daily Mn intake from breast milk ranged from 1.2 µg Mn/kg/day (3 weeks) to 0.16 µg Mn/kg/day (18 months), with the highest intakes at the youngest age stage we considered, 3 weeks. Estimated daily Mn intake from formula products reconstituted with 0 µg Mn/L water ranged from 130 µg Mn/kg/day (3 weeks) to 4.8 µg Mn/kg/day (18 months) with the highest intakes at 3 weeks. Formula products provided 28 to 520 times greater than the mean daily intake of Mn from breast milk for the 4 age stages that we considered. Estimated daily Mn intake from formula products reconstituted with water containing 250 µg Mn/L ranged from 12 µg Mn/kg/day to 170 µg Mn/kg/day, which exceeds the United States Environmental Protection Agency Reference Dose of 140 µg Mn/kg/day for adults. ConclusionsMn deficiency is highly unlikely with exclusive breast milk or infant formula feeding, but established tolerable daily intake levels for Mn may be surpassed by some of these products when following labeled instructions.

show abstract

Section: The Toxicity Of Manganese By Ingestion Exposurementioning

confidence: 99%

Estimating daily intakes of manganese due to breast milk, infant formulas, or young child nutritional beverages in the United States and France: Comparison to sufficiency and toxicity thresholds

Mitchell¹,

Frisbie

Roudeau

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Recently, Schuh reported on a severe case of parkinsonism in a 37‐year‐old women . The patient reported taking several herbal and food supplements.…”

Section: Possible Health Effectsmentioning

confidence: 99%

“…Recently, Schuh reported on a severe case of parkinsonism in a 37-year-old women. [152] The patient reported taking several herbal and food supplements. This included manganese intake at a dose of up to 100 mg per day for more than two years.…”

Section: Case Reports On Health Effects Related To Oral Manganese Expmentioning

confidence: 99%

Dietary Manganese Exposure in the Adult Population in Germany—What Does it Mean in Relation to Health Risks?

Sachse

Kolbaum

Ziegenhagen

et al. 2019

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Manganese is both an essential nutrient and a potential neurotoxicant. Therefore, the question arises whether the dietary manganese intake in the German population is on the low or high side. Results from a pilot total diet study in Germany presented here reveal that the average dietary manganese intake in the general population in Germany aged 14–80 years is about 2.8 mg day−1 for a person of 70 kg body weight. This exposure level is within the intake range of 2–5 mg per person and day as recommended by the societies for nutrition in Germany, Austria, and Switzerland. No information on the dietary exposure of children in Germany can be provided so far. Although reliable information on health effects related to oral manganese exposure is limited, there is no indication from the literature that these dietary intake levels are associated with adverse health effects either by manganese deficiency or excess. However, there is limited evidence that manganese taken up as a highly bioavailable bolus, for example, uptake via drinking water or food supplements, could pose a potential risk to human health—particularly in certain subpopulations—when certain intake amounts, which are currently not well defined, are exceeded.

show abstract

“…These neurotoxic effects include dystonia, impaired speech and poor cognition, and they have been shown to be a particular threat to the developing central nervous system (CNS) throughout childhood (Zoni and Lucchini, 2013; Bjørklund et al, 2017; Lao et al, 2017). Adults are less susceptible to manganese toxicity than children 1 , although neurotoxic (Olanow, 2004; Bowler et al, 2016; Schuh, 2016) and carcinogenic/teratogenic (Gerber et al, 2002) effects have been documented following moderate chronic exposure in adults. Manganism, the classic picture of chronic manganese toxicity in humans, is characterized by motor deficits that closely resemble Parkinson’s disease (PD) in the early stages (Andruska and Racette, 2015).…”

Section: Pharmacodynamicsmentioning

confidence: 99%

Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration

Cloyd

Koren

Abisambra

2018

Front. Aging Neurosci.

View full text Add to dashboard Cite

Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and other body systems. MEMRI has since been employed in the investigation of physiology in many animal models and in humans. Here, we review historical perspectives that follow the evolution of applied MRI research into MEMRI with particular focus on its potential toxicity. Furthermore, we discuss the more current in vivo investigative uses of MEMRI in CNS investigations and the brief but decorated clinical usage of chelated manganese compound mangafodipir in humans.

show abstract

Possible Parkinson's Disease Induced by Chronic Manganese Supplement Ingestion

Abstract: AI = Adequate intake, EMS = Eosinophilia myalgia syndrome, MTM = Medication therapy management, UL = Tolerable upper limit.

Cited by 12 publications

References 0 publications

Estimating daily intakes of manganese due to breast milk, infant formulas, or young child nutritional beverages in the United States and France: Comparison to sufficiency and toxicity thresholds

Estimating daily intakes of manganese due to breast milk, infant formulas, or young child nutritional beverages in the United States and France: Comparison to sufficiency and toxicity thresholds

Dietary Manganese Exposure in the Adult Population in Germany—What Does it Mean in Relation to Health Risks?

Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration

Contact Info

Product

Resources

About