Possible mechanisms for the putative antiatherogenic and antitumorigenic effects of conjugated polyenoic fatty acids

Farquharson, Andrew J.; Wu, Huiyun; Grant, I. S.; Graf, Brigitte A.; Choung, Jai Jun; Eremin, O.; Heys, Steven Darryll; Wahle, Klaus W.J.

doi:10.1007/bf02562337

Cited by 17 publications

(11 citation statements)

References 3 publications

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“…Especially, the antiatherogenic properties of CLA are now supported by many animal studies in rabbits (16), mice (32), and hamsters (37). Studies in cell cultures have demonstrated protective properties (8,11,15,38). In animals, these properties can be observed while using either the CLA isomeric mixture (cis-9,trans-11-and trans-10,cis-12-CLA, 50:50) (17,37) or selected CLA isomers (cis-9,trans-11-or trans-10,cis-12-CLA) (16,32).…”

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confidence: 97%

“…21). On the other hand, both in vitro and in vivo data recently indicated that part of the beneficial effects of CLA occurs through the modulation of vascular inflammatory and oxidant stress factors [cytokines and cyclooxygenase (COX)] (8,15,38) as well as through the expression of adhesion molecules (VCAM and ICAM) (7,11). This regulation involves the interaction of CLA with transcription factors such as peroxisome proliferator-activating receptors (PPARs), liver X receptors (LXRs), and NF-B targeting the gene expression clusters downstream (2,8,15,38).…”

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confidence: 99%

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Acis-9,trans-11-conjugated linoleic acid-rich oil reduces the outcome of atherogenic process in hyperlipidemic hamster

Valeille¹,

Férézou²,

Amsler³

et al. 2005

American Journal of Physiology-Heart and Circulatory Physiology

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in several animal models, including hamsters, but the mechanism of action of the main food-derived CLA isomer is unknown in this species. This study thus focused on cis-9,trans-11-CLA (rumenic acid), and its effect was compared with that of fish oil, which is known to influence several aspects of atherogenesis. Syrian hamsters were fed (for 12 wk) diets containing 20% (wt/wt) butter fat (B diet) or the same diet augmented with either 1% (wt/wt) of a cis-9,trans-11-CLArich oil (BR diet) or 1% (wt/wt) fish oil (BF diet). The BR diet induced the lowest aortic lipid deposition (from Ϫ30% to Ϫ45%) among the butter oil-fed hamsters. In this group, plasma also displayed a reduced non-HDL-to-HDL-cholesterol ratio (21% less than in the butter oil group) and inflammatory serum amyloid A levels (70 -80%) and an improvement of anti-oxidized LDL paraoxonase activity (all P Ͻ 0.05). Compared with the B group, the beneficial effects of the BR diet could be further explained in part by preventing the high VCAM-1 expression rate, increasing (30%) ATP-binding cassette subfamily A1 expression in the aorta, and downregulating expression of inflammatory-related genes (TNF-␣, IL-1␤, and cyclooxygenase 2, 2-to 2.8-fold, P Ͻ 0.05). This effect was partly associated with an activation of peroxisome proliferator-activating receptor (PPAR)/liver X receptor (LXR)-␣ signaling cascade. Interestingly, activation of PPAR/LXR-␣ signaling was not observed in hamsters fed the BF diet, in which the early signs of atherogenesis were increased. In conclusion, this study demonstrated that milk fat-rich cis-9,trans-11-CLA reduces the atherogenic process in hyperlipidemic hamsters.

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confidence: 97%

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confidence: 99%

Acis-9,trans-11-conjugated linoleic acid-rich oil reduces the outcome of atherogenic process in hyperlipidemic hamster

Valeille¹,

Férézou²,

Amsler³

et al. 2005

American Journal of Physiology-Heart and Circulatory Physiology

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“…It also has been reported that 1% CLA sodium salt (mixture of c9,t11-and t10,c12) significantly reduced the growth of prostate tumors in SCID mice [17]. It has been reported that 100 mM CLA increased the level of mRNA for glutathione peroxidase and reduced the diacylglycerol contents in human prostate cancer cells (PC3) [35]. Ochoa et al [36] reported that CLA mixture (c9 t11:t10 c12) was able to decrease PC-3 proliferation at 100 and 150 lM (19.9% of control and 59.3% of control, respectively).…”

Section: Discussionmentioning

confidence: 96%

“…Duncan's multiple range tests and paired t test were used to assess the statistical significance between the treated groups, using the SAS System [35].…”

Section: Discussionmentioning

confidence: 99%

Selectively Hydrogenated Soybean Oil Exerts Strong Anti‐Prostate Cancer Activities

Jung¹,

Choi²,

Oh³

et al. 2010

Lipids

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Prostate cancer is the second leading cause of male deaths due to cancer in the United States. Hydrogenated vegetable oils have been suspected of inducing adverse health effects, including atherosclerosis and cancer. Here we report that a selectively hydrogenated soybean oil (SHSO) containing a high quantity of conjugated linoleic acids showed remarkably strong anticarcinogenic activity against prostate cancer in the rat model (Copenhagen rats with MAT-LyLu syngeneic rat prostate cancer cells) study in vivo and human prostate carcinoma cell lines studies in vitro, as compared with native soybean oil. A 5% dietary supplementation with SHSO inhibited the growth of prostate cancer by 80% in vivo. The TUNEL method and immunohistochemical staining assays of bax, bcl-2, and survivin clearly showed that SHSO induced prostate cancer cell apoptosis in the tested rats. DNA fragmentation analysis in vitro further confirmed the apoptotic activity of SHSO on the MAT-LyLu prostate cancer cells. The SHSO also showed strong cytotoxicity on human prostate cancer cells (DU145 and PC3). This represents the first report demonstrating the significant anticancer activities of hydrogenated vegetable oils at low levels of dietary supplementation.

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“…CLAs have been reported to elicit beneficial effects on a variety of other important biomarkers of disease related to diabetes prevention [58] and reduction of cholesterolinduced atherosclerotic lesions in aortic arch and thoracic aorta in a number of animal models by plaque regression [59][60][61]. Mixtures of CLA isomers have also been found to decrease body fat in humans by 3% through a modification of eicosanoid synthesis [62] and to increase the level of antioxidant enzymes in cells [63]. On the other hand, studies on the pinolenic acid (18:3, cis,cis,cis 5 , 9 , 12 ) have proven beneficial functions in the human body: decreasing lipids, increasing HDL and prostacyclin, decreasing blood pressure, inhibiting aggregation of platelets as well as anti-inflammatory properties [64,65].…”

Section: Introductionmentioning

confidence: 99%

Recent trends in the advanced analysis of bioactive fatty acids

Ruiz-Rodrı́guez

Reglero

Ibáñez

2010

Journal of Pharmaceutical and Biomedical Analysis

119

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The consumption of dietary fats have been long associated to chronic diseases such as obesity, diabetes, cancer, arthritis, asthma, and cardiovascular disease; although some controversy still exists in the role of dietary fats in human health, certain fats have demonstrated their positive effect in the modulation of abnormal fatty acid and eicosanoid metabolism, both of them associated to chronic diseases. Among the different fats, some fatty acids can be used as functional ingredients such as alpha-linolenic acid (ALA), arachidonic acid (AA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), gamma-linolenic acid (GLA), stearidonic acid (STA) and conjugated linoleic acid (CLA), among others. The present review is focused on recent developments in FAs analysis, covering sample preparation methods such as extraction, fractionation and derivatization as well as new advances in chromatographic methods such as GC and HPLC. Special attention is paid to trans fatty acids due its increasing interest for the food industry.

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Possible mechanisms for the putative antiatherogenic and antitumorigenic effects of conjugated polyenoic fatty acids

Cited by 17 publications

References 3 publications

Acis-9,trans-11-conjugated linoleic acid-rich oil reduces the outcome of atherogenic process in hyperlipidemic hamster

Acis-9,trans-11-conjugated linoleic acid-rich oil reduces the outcome of atherogenic process in hyperlipidemic hamster

Selectively Hydrogenated Soybean Oil Exerts Strong Anti‐Prostate Cancer Activities

Recent trends in the advanced analysis of bioactive fatty acids

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