Selectively Hydrogenated Soybean Oil Exerts Strong Anti‐Prostate Cancer Activities

Yoon

Journal of Food Science

2012

Self Cite

The chemical properties and oxidative stability of perilla oils obtained from roasted perilla seeds as affected by extraction methods (supercritical carbon dioxide [SC-CO(2)], mechanical press, and solvent extraction) were studied. The SC-CO(2) extraction at 420 bar and 50 °C and hexane extraction showed significantly higher oil yield than mechanical press extraction (P < 0.05). The fatty acid compositions in the oils were virtually identical regardless of the extraction methods. The contents of tocopherol, sterol, policosanol, and phosphorus in the perilla oils greatly varied with the extraction methods. The SC-CO(2) -extracted perilla oils contained significantly higher contents of tocopherols, sterols, and policosanols than the mechanical press-extracted and hexane-extracted oils (P < 0.05). The SC-CO(2) -extracted oil showed the greatly lower oxidative stability than press-extracted and hexane-extracted oils during the storage in the oven under dark at 60 °C. However, the photooxidative stabilities of the oils were not considerably different with extraction methods.

Section: Methodsmentioning

confidence: 99%

Chemical Properties and Oxidative Stability of Perilla Oils Obtained From Roasted Perilla Seeds As Affected by Extraction Methods

Yoon

Journal of Food Science

2012

Self Cite

Polish Journal of Veterinary Sciences

“…Surprisingly, Jung et al (2011) showed, that selectively hydrogenated soybean oil, rich in CLA, exerts strong anti prostate cancer activities, in vivo (rats) and in vitro (human prostate carcinoma cell lines).…”

Section: Cla and Cancermentioning

confidence: 99%

Biological effects of conjugated linoleic acids supplementation

Oleszczuk¹,

Oleszczuk²,

Siwicki³

et al. 2012

Conjugated linoleic acids (CLA) are a group of polyunsaturated fatty acids (PUFA) with a single pair of conjugated double bonds. The major natural CLA isomer is 18:2 cis-9, trans-11 (c9, t11) linoleic acid, or rumenic acid (RA). Chemically synthesized CLA is also available, mostly as a mixture of RA and 18:2 trans-10, cis-12 (t10, c12) isomers in equal amounts (50:50). Consumption of ruminant meat (beef and lamb) and dairy products (milk and cheese) is the main source of dietary exposure to CLA. Despite numerous studies on animal and human models (tumorigenesis, obesity, immune response) it has not been established whether additional supplementation of CLA is of benefit. Moreover, some studies, conducted both in animals and in humans, reveal that CLA isomers may induce insulin resistance. Presently, balanced diet rich in CLA from natural sources is recommended. The purpose of this review was to sum up the results available in the literature.

“…The degree of inhibitory effects of CLA against PhIP-induced mutagenicity were estimated at 38% [40]. To confirm the apoptotic activity of CLA against prostate cancer, Jung et al reported anticarcinogenic activity of selectively hydrogenated soybean oil (SHSO) that was modulated with high quantity of CLA [41]. The 5% of dietary SHSO showed the best results to inhibit the prostate cancer in the rat model (Copenhagen rat), by an estimation of 80%.…”

Section: Prostate Cancermentioning

confidence: 99%

The Effects of Conjugated Linoleic Acids on Cancer

et al. 2021

Conjugated linoleic acids (CLA) are distinctive polyunsaturated fatty acids. They are present in food produced by ruminant animals and they are accumulated in seeds of certain plants. These naturally occurring substances have demonstrated to have anti-carcinogenic activity. Their potential effect to inhibit cancer has been shown in vivo and in vitro studies. In this review, we present the multiple effects of CLA isomers on cancer development such as anti-tumor efficiency, anti-mutagenic and anti-oxidant activity. Although the majority of the studies in vivo and in vitro summarized in this review have demonstrated beneficial effects of CLA on the proliferation and apoptosis of tumor cells, further experimental work is needed to estimate the true value of CLA as a real anti-cancer agent.