Possible involvement of stem cell factor and endothelin‐1 in the emergence of pigmented squamous cell carcinoma in oral mucosa

Satomura, Kimio; Tokuyama, Reiko; Yamasaki, Yasuhumi; Yuasa, Tetsuya; Tatehara, Seiko; Ishimaru, Naozumi; Hayashi, Yoshio; Nagayama, Masaru

doi:10.1111/j.1600-0714.2007.00587.x

Cited by 19 publications

(28 citation statements)

References 13 publications

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“…However, the hypothesis that neoplastic cells may produce factors stimulating proliferation and differentiation of melanocytes, such as stem cell factor and endothelin-1, has been proposed (6). The mechanism of colonization of melanocytes in nonmelanocytic tumors, including SCC, is still unknown.…”

Section: Pigmented Cervical Intraepithelial Neoplasiamentioning

confidence: 99%

Pigmented Cervical Intraepithelial Neoplasia

Ishida

Kagotani

Yoshida

et al. 2013

International Journal of Gynecological Pathology

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Section: Pigmented Cervical Intraepithelial Neoplasiamentioning

confidence: 99%

Pigmented Cervical Intraepithelial Neoplasia

Ishida

Kagotani

Yoshida

et al. 2013

International Journal of Gynecological Pathology

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“…Together these agents account for the melanin pigmentation sometimes observed in association with inflammatory conditions of skin or oral mucosa [41,46], such as oral lichen planus [6] and healing after periodontal surgery [47]. …”

Section: Introductionmentioning

confidence: 99%

Melanin: the biophysiology of oral melanocytes and physiological oral pigmentation

et al. 2014

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The presence of melanocytes in the oral epithelium is a well-established fact, but their physiological functions are not well defined. Melanin provides protection from environmental stressors such as ultraviolet radiation and reactive oxygen species; and melanocytes function as stress-sensors having the capacity both to react to and to produce a variety of microenvironmental cytokines and growth factors, modulating immune, inflammatory and antibacterial responses. Melanocytes also act as neuroendocrine cells producing local neurotransmitters including acetylcholine, catecholamines and opioids, and hormones of the melanocortin system such as proopiomelanocortin, adrenocorticotropic hormone and α-melanocyte stimulating hormone, that participate in intracellular and in intercellular signalling pathways, thus contributing to tissue homeostasis.There is a wide range of normal variation in melanin pigmentation of the oral mucosa. In general, darker skinned persons more frequently have oral melanin pigmentation than light-skinned persons. Variations in oral physiological pigmentation are genetically determined unless associated with some underlying disease.In this article, we discuss some aspects of the biophysiology of oral melanocytes, of the functions of melanin, and of physiological oral pigmentation.

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“…Satomura et al reported a case of pigmented squamous cell carcinoma of the hard palate. The authors clearly demonstrated stem cell factor and endothelin-1 expression in the neoplastic squamous cells, which may have led to the development of melanocytic colonization in squamous cell carcinoma (11). …”

Section: Discussionmentioning

confidence: 99%

“…For example, it has been suggested that the presence of melanocytes may be presented as heterotopic cell rests resulting from aberrant melanocytic migration during the embryonic period (4). It has also been hypothesized that the epithelial cells may produce factors that simulate the proliferation and differentiation of melanocytes, such as stem cell factor and endothelin-1 (11). Satomura et al reported a case of pigmented squamous cell carcinoma of the hard palate.…”

Section: Discussionmentioning

confidence: 99%

Pigmented median raphe cyst of the penis with consideration of the possible mechanism of melanocytic colonization: A case report

et al. 2013

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Median raphe cyst is a rare lesion located on the median raphe. The cyst wall is lined by cuboidal to columnar cells, transitional (urothelial) cells, stratified squamous cells or a mixture of these. The normal urethral mucosa and the median raphe cyst usually lack melanocytes and/or melanin pigment. However, albeit extremely rare, the presence of melanin pigment and/or melanocytes in median raphe cyst, namely pigmented median raphe cyst, has been previously reported. The current case report presents the sixth case of pigmented median raphe cyst and discusses the possible mechanism of melanocytic colonization in this tumor. A 48-year-old male presented with a nodule on the ventral surface of the penis. Histopathological study revealed that the cyst wall was covered by uniform bland cuboidal to urothelial cells. The peculiar observation was the presence of dendritic melanocytes among the epithelial cells. Therefore, a diagnosis of pigmented median raphe cyst was determined. Immunohistochemically, stem cell factor and endothelin-1 were not expressed in the epithelial cells of the cyst wall. It is well-known that melanocytes are rarely found in various non-melanocytic tumors, a phenomenon termed ‘colonization’. The mechanism by which melanocytes appear in median raphe cyst remains unclear. The present report is the first to demonstrate that melanocytic proliferation and differentiation factors, such as stem cell factor and endothelin-1, are not involved in the pigmentation of median raphe cyst. In addition, aberrant melanocytic migration may contribute to the development of this type of lesion.

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Possible involvement of stem cell factor and endothelin‐1 in the emergence of pigmented squamous cell carcinoma in oral mucosa

Cited by 19 publications

References 13 publications

Pigmented Cervical Intraepithelial Neoplasia

Pigmented Cervical Intraepithelial Neoplasia

Melanin: the biophysiology of oral melanocytes and physiological oral pigmentation

Pigmented median raphe cyst of the penis with consideration of the possible mechanism of melanocytic colonization: A case report

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