Pigmented Cervical Intraepithelial Neoplasia

Ishida, Mitsuaki; Kagotani, Akiko; Yoshida, Keiko; Okabe, Hidetoshi

doi:10.1097/pgp.0b013e3182585c5e

Cited by 10 publications

(16 citation statements)

References 6 publications

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“…While some melanocytic proliferation is normal in the anagen phase of hair growth, the reason behind the degree of melanocyte proliferation in MCMH is yet unknown . Hypotheses as to what is driving melanocytic hyperplasia in MCMH include production of melanocyte chemotactic factor produced by the tumor or paracrine signaling by keratinocytes …”

Section: Discussionmentioning

confidence: 99%

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Matrical carcinoma with melanocytic hyperplasia mimicking nodular melanoma in an elderly Mexican male

2019

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Matrical carcinoma with melanocytic hyperplasia (MCMH), previously referred to as malignant melanocytic matricoma, is a rare variant of the uncommon pilomatrical carcinoma, occurring most often on the head/neck and upper backs of middle-aged men. Nodular lesions may resemble pigmented basal cell carcinoma or melanoma clinically. We present a case of MCMH in a Hispanic patient with history of melanoma. Histopathological clues to appropriate diagnosis include basaloid cells, numerous atypical mitotic figures, matrical differentiation, shadow cells, strong diffuse nuclear and cytoplasmic expression of ß-catenin, and interspersed pigmented dendritic melanocytes.

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Section: Discussionmentioning

confidence: 99%

“…Local recurrence rates for pilomatrical carcinomas are reported to be 23 to 46% . There are no chemotherapy regimens or radiation protocols yet established.…”

Section: Discussionmentioning

confidence: 99%

Matrical carcinoma with melanocytic hyperplasia mimicking nodular melanoma in an elderly Mexican male

2019

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“…The pathogenesis of blue nevi of the genital tract is not yet completely understood, and furthermore, the pathogenesis of the melanocytic colonization of non-melanocytic lesions, including pigmented cervical intraepithelial neoplasia, also remains unclear (7). However, certain hypotheses have been proposed.…”

Section: Discussionmentioning

confidence: 99%

Endometrioid adenocarcinoma concurrent with a blue nevus of the endometrium and uterine cervix: A case report

et al. 2013

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A blue nevus is a benign melanocytic lesion that is composed of spindle-shaped pigmented melanocytes. Although the uterine cervix is believed to be the most common extracutaneous location of blue nevi, the occurrence of these lesions in the endometrial stroma has been reported, albeit rarely. The present study describes a case of endometrioid adenocarcinoma concurrent with a blue nevus of the endometrium and uterine cervix. A 58-year-old female presented with abnormal vaginal bleeding. A biopsy from the endometrium revealed an endometrioid adenocarcinoma and subsequently, a total hysterectomy was performed. Histopathological study revealed the proliferation of columnar cells that formed irregularly-shaped tubular and cribriform glands. The neoplastic columnar cells had large, round to oval nuclei containing a single small nucleolus. Focal squamous differentiation was noted. In the stroma of the non-neoplastic endometrium, single or small aggregates of short spindle-shaped cells containing melanin without atypia were observed. These melanocytes were also present in the endocervix. Therefore, the final diagnosis was of endometrioid adenocarcinoma concurrent with a blue nevus of the endometrium and cervix. This is the first documented case of a blue nevus of the endometrium and endocervix. The pathogenesis of blue nevi of the genital tract is not yet completely understood. Possible origins of these cells include Schwann cells or perineural cells of the peripheral nerve fiber or the abnormal migration of neural crest-derived cells.

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“…It is well-known that non-neoplastic melanocytes are rarely found in various benign and malignant non-melanocytic tumors of the various sites, a phenomenon known as ‘colonization’ (6–10). The urethral mucosa is normally devoid of melanocytes and the mechanism by which melanocytes and/or melanin pigment appear in median raphe cyst remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Pigmented median raphe cyst of the penis with consideration of the possible mechanism of melanocytic colonization: A case report

et al. 2013

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Median raphe cyst is a rare lesion located on the median raphe. The cyst wall is lined by cuboidal to columnar cells, transitional (urothelial) cells, stratified squamous cells or a mixture of these. The normal urethral mucosa and the median raphe cyst usually lack melanocytes and/or melanin pigment. However, albeit extremely rare, the presence of melanin pigment and/or melanocytes in median raphe cyst, namely pigmented median raphe cyst, has been previously reported. The current case report presents the sixth case of pigmented median raphe cyst and discusses the possible mechanism of melanocytic colonization in this tumor. A 48-year-old male presented with a nodule on the ventral surface of the penis. Histopathological study revealed that the cyst wall was covered by uniform bland cuboidal to urothelial cells. The peculiar observation was the presence of dendritic melanocytes among the epithelial cells. Therefore, a diagnosis of pigmented median raphe cyst was determined. Immunohistochemically, stem cell factor and endothelin-1 were not expressed in the epithelial cells of the cyst wall. It is well-known that melanocytes are rarely found in various non-melanocytic tumors, a phenomenon termed ‘colonization’. The mechanism by which melanocytes appear in median raphe cyst remains unclear. The present report is the first to demonstrate that melanocytic proliferation and differentiation factors, such as stem cell factor and endothelin-1, are not involved in the pigmentation of median raphe cyst. In addition, aberrant melanocytic migration may contribute to the development of this type of lesion.

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Pigmented Cervical Intraepithelial Neoplasia

Cited by 10 publications

References 6 publications

Matrical carcinoma with melanocytic hyperplasia mimicking nodular melanoma in an elderly Mexican male

Matrical carcinoma with melanocytic hyperplasia mimicking nodular melanoma in an elderly Mexican male

Endometrioid adenocarcinoma concurrent with a blue nevus of the endometrium and uterine cervix: A case report

Pigmented median raphe cyst of the penis with consideration of the possible mechanism of melanocytic colonization: A case report

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