Possible involvement of nitric oxide in long-term potentiation

Böhme, Georg Andrees; Bon, Christelle L. M.; Stutzmann, Jean‐Marie; Doble, Adam; Blanchard, Jean‐Charles

doi:10.1016/0014-2999(91)90505-k

Cited by 603 publications

(236 citation statements)

References 9 publications

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“…In these cells NO has been implicated in synaptic plasticity phenomena like long-term potentiation (LTP) in the hippocampus [1,2] and long-term synaptic depression (LTD) in the cerebellum [21]. In these processes NO is suggested to act as a possible retrograde messenger, carrying information from postsynaptic elements (e.g., CAI pyramidal neurons and cerebellar Purkinje cells) to presynaptic terminals [see ref .…”

Section: Discussionmentioning

confidence: 99%

Aldehyde fixation differentially affects distribution of diaphorase activity but not of nitric oxide synthase immunoreactivity in rat brain

Buwalda

Nyakas

Gast

et al. 1995

Brain Research Bulletin

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Aldehyde fixation differentially affects distribution of diaphorase activity but not of nitric oxide synthase immunoreactivity in rat brain Buwalda, Bauke; Nyakas, C.; Gast, J.; Luiten, P.G.M. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. ABSTRACT: The effect of aldehyde fixation on NADPH-and NADH-dependent diaphorase (d) histochemistry and nitric oxide synthase (NOS) immunocytochemislry in the brain was investigated by comparing the distribution of these enzymes in in situ nitrocellulose blots of unfixed brain sections with that in aidehyde-fixed brain sections. Substitution of NADPH by NADH yielded no gross differences in cellular distbribution in the native blot, whereas in fixed sections NADH produced nonspecific staining of the entire section. In the in situ blot NADPHd histoohemislry therafore visualized general nitroblue tatrazolium reductass (NBTr) activity, which was particularly strong in hippocampal pyramidal neurons and cerabellar Purkinje cells. Aldehyde fixation abolished the anatomical pattern of general NBTr activity and changed the hiatochemical distribution in that of the NADPHd activity associated with the distribution of NOS-I immunoreacfivity (ir). Fixation intensified NADPHd histochemical staining in specific neurone, resulting in outstanding, Golgilike staining of these neurons in several brain regions, whereas the general NBTr activity in pyramidal and Purkinje cells disappeared, in contrast to the histochemical diaphorase dislribution, the distribution of NOS-I ir on blots and in aldehyde-fixed brain sections was similar. No NOS was observed in hippocampal pyramidal and carebellar Purkinje neurons. In regions like cerebral and cerebellsr cortex and striatum the applied anti NOS-I serum had a higher affinity for the native protein. It is concluded that aldehydes, rather than to progressively suppress NOS-unrelated enzymes, differentially elicit NADPHd activity in some groups of neurons while leaving NOS-ir unaffected.

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Section: Discussionmentioning

confidence: 99%

Aldehyde fixation differentially affects distribution of diaphorase activity but not of nitric oxide synthase immunoreactivity in rat brain

Buwalda

Nyakas

Gast

et al. 1995

Brain Research Bulletin

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“…Thus, postsynaptic activity in target structures significantly influences the structure and contacts of presynaptic retinal axons, suggesting a role for a retrograde messenger. Nitric oxide (NO) has been proposed as a diffusible retrograde messenger in the maintenance of hippocampal long-term potentiation (LTP) (Bohme et al, 1991;O'Dell et al, 1991;Schuman and Madison, 1991;Haley et al, 1992;cf. Gribkoff and Lum-Ragan, 1992) and, by analogy, in activity-dependent refinement of connections in the visual pathway during development (Montague et al, 1991;Wu et al, 1994;.…”

Section: Abstract: Diffusible Messenger; Visual System; Lateral Genimentioning

confidence: 99%

A Role for Nitric Oxide in the Development of the Ferret Retinogeniculate Projection

et al. 1996

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The ferret retinogeniculate projection segregates into eyespecific layers during the first postnatal week and into ON/OFF sublaminae, which receive inputs from either on-center or offcenter retinal ganglion cells, during the third and fourth postnatal weeks. The restriction of retinogeniculate axon arbors into eye-specific layers appears to depend on action potential activity (Shatz and Stryker, 1988) but does not require activation of NMDA receptors (Smetters et al., 1994). The formation of ON/OFF sublaminae is also activity-dependent and is disrupted by in vivo blockade of NMDA receptors (Hahm et al., 1991). To investigate a possible mechanism whereby blockade of postsynaptic NMDA receptors in the lateral geniculate nucleus (LGN) results in changes in the size and position of presynaptic axon arbors, we tested the role of the diffusible messenger nitric oxide (NO) in the development of the retinogeniculate pathway. We found previously that NO synthase (NOS) is transiently expressed in LGN cells during the refinement of retinogeniculate projections . In this study, treatment with N G -nitro-L-arginine (L-NoArg), an arginine analog that inhibits NOS, during the third and fourth postnatal weeks resulted in an overall pattern of sublamination that was significantly reduced compared with normal and control animals. Single retinogeniculate axon arbors were located in the middle of eye-specific layers rather than toward the inner or outer half as in normal or control animals. The effect of NOS inhibition was not a consequence of the hypertensive effect of L-NoArg. In contrast to the effect of L-NoArg on the formation of ON/OFF sublaminae, treatment with L-NoArg during the first postnatal week did not disrupt the formation of eye-specific layers. Biochemical assays indicated significant inhibition of NOS during both treatment periods. These data suggest that NO acts together with NMDA receptors in activity-dependent refinement of connections during a specific phase of retinogeniculate development. Key words: diffusible messenger; visual system; lateral geniculate nucleus (LGN); pattern formation; eye-specific layers; ON/ OFF sublaminae; neuronal activityThe precise pattern of connections underlying adult visual processing in mammals arises from the refinement of less specific connectivity present early in development. The mechanisms by which diffuse connections are refined rely at least in part on neuronal activity. In the ferret, retinogeniculate connections are refined in two distinct phases. During the first postnatal week, retinal axons within the lateral geniculate nucleus (LGN) segregate into eye-specific layers (Linden et al., 1981). During the third and fourth postnatal weeks, afferents to the A and A1 layers, which receive input from the contralateral and ipsilateral eye, respectively, further segregate into sublaminae. The inner sublamina receives inputs from on-center retinal ganglion cells, whereas the outer sublamina receives inputs from off-center retinal ganglion cells (Stryker and Zahs, 1983;Hahm and S...

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“…These criteria include the ability of the molecule to produce a persistent potentiation in synaptic transmission when added to hippocampal slices (Sweatt, 1999). Other small messenger molecules that have been shown to meet these criteria are arachidonic acid (Williams et al, 1989), nitric oxide (Böhme et al, 1991;Zhuo et al, 1993), carbon monoxide (Zhuo et al, 1993), and cAMP (Frey et al, 1993).…”

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confidence: 99%

Potentiation of Hippocampal Synaptic Transmission by Superoxide Requires the Oxidative Activation of Protein Kinase C

Knapp¹,

2002

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Recent evidence suggests that reactive oxygen species (ROS), including superoxide, are not only neurotoxic but function as small messenger molecules in normal neuronal processes such as synaptic plasticity. Consistent with this idea, we show that brief incubation of hippocampal slices with the superoxidegenerating system xanthine/xanthine oxidase (X/XO) produces a long-lasting potentiation of synaptic transmission in area CA1. We found that X/XO-induced potentiation was associated with a persistent superoxide-dependent increase in autonomous PKC activity that could be isolated via DEAE column chromatography. The X/XO-induced potentiation was blocked by the inhibition of PKC, indicating that the superoxidedependent increase in autonomous PKC activity was necessary for the potentiation. We also found that X/XO-induced potentiation and long-term potentiation (LTP) occluded one another, suggesting that these forms of plasticity share similar cellular mechanisms. In further support of this idea, we found that a persistent, superoxide-dependent increase in autonomous PKC activity isolated via DEAE column chromatography also was associated with LTP. Taken together, our findings indicate that X/XO-induced potentiation and LTP share similar cellular mechanisms, including superoxide-dependent increases in autonomous PKC activity. Finally, our findings suggest that superoxide, in addition to its well known role as a neurotoxin, also can be considered a small messenger molecule critical for normal neuronal signaling.

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Possible involvement of nitric oxide in long-term potentiation

Cited by 603 publications

References 9 publications

Aldehyde fixation differentially affects distribution of diaphorase activity but not of nitric oxide synthase immunoreactivity in rat brain

Aldehyde fixation differentially affects distribution of diaphorase activity but not of nitric oxide synthase immunoreactivity in rat brain

A Role for Nitric Oxide in the Development of the Ferret Retinogeniculate Projection

Potentiation of Hippocampal Synaptic Transmission by Superoxide Requires the Oxidative Activation of Protein Kinase C

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