Possible involvement of cholinergic and adrenergic mechanisms in changing contractility of guinea pig ileum by Ipomoea carnea

Hore, S. K.; Ottalwar, Ram; Koley, K. M.; Pathak, Ambadas

doi:10.1016/s0378-8741(00)00173-2

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…The effect of Ipomoea carnea leaf juice (10–10,000 mg/ml) and its mechanism (s) of action on changing contractility of guinea pig ileum indicated that I. carnea juice contracted the guinea pig ileum in a dose‐dependent manner. In addition, contractile response in tissue incubated to atropine (1 mg/ml) was blocked that suggests muscarinic receptors agonistic effect possibly mediated contractile response of I. carnea (Hore, Ottalwar, Koley, & Pathak, ).…”

Section: Resultsmentioning

confidence: 97%

The effects of medicinal plants on muscarinic receptors in various types of smooth muscle

Gholamnezhad

Ghorani

Saadat

et al. 2018

Phytotherapy Research

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Pharmacological agents that can affect muscarinic receptors are commonly used to treat or manage various diseases. Medicinal plants have been used from ancient time to treat cardiovascular, gastrointestinal, respiratory, and urogenital disorders, which may related to their muscarinic receptors effects. Several pharmacological studies revealed the inhibitory or stimulatory effect of some herbal plants on muscarinic receptors. Medline, PubMed, Science Direct, Scopus, and Google Scholar as online database were searched from the beginning of 1983 to March 2018 using following keywords: muscarinic receptor, medicinal plant, herbal medicine, and smooth muscle, animal, human, in vivo, and in vitro. The original studies in English language were included. Based on the results of the reviewed articles, more than 70 medicinal plants extracts or constituents affected muscarinic receptors (stimulatory or inhibitory) of smooth muscles in cardiovascular, gastrointestinal, respiratory, and urogenital systems. Among them, there are some tropical plant and herbs that have been traditionally used as food additive. The therapeutic properties of these plants may be regarded in treatment of cardiovascular (hypertension and tachycardia); gastrointestinal (diarrhea, colitis, and constipation); and urological (overactive bladder, abortion, and preterm labor) diseases. However, more clinical trials are needed to use some of these medicinal plants in clinical target therapy.

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Section: Resultsmentioning

confidence: 97%

The effects of medicinal plants on muscarinic receptors in various types of smooth muscle

Gholamnezhad

Ghorani

Saadat

et al. 2018

Phytotherapy Research

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“…Atropine is a muscarinic cholinergic receptor blocker.Hence, inhibition of contractile responses of ACh and VWE by atropine indicates that the responses of these two agonists were mediated through muscarinic receptors. There seems to be one or more than one of the three possible mechanisms responsible for this contractile action of VWE-(i) stimulation of ACh release from the cholinergic nerve endings, (ii) inhibition of acetylcholinesterase enzyme at the neuroeffector junction, or (iii) direct activation of the muscarinic receptors of rat duodenal smooth muscle (Hore et al, 1999). The combination of ACh and an anticholinesterase agent produces a potentiated effect (Kela et al, 1995), because the fraction of ACh molecules, which is normally destroyed by acetylcholinesterase enzyme in absence of anticholinesterase, becomes available to act on the receptors to produce extra effect.…”

Section: Resultsmentioning

confidence: 99%

Spasmodic response and neurogenic mechanism of water extract of Vernonia cinerea (L.) Less. on rat duodenum

Pandey¹,

Kasana²,

Hore³

2011

Planta Med

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Use of different agonists and antagonists for elucidating the mechanism of aqueous extract of Vernonia cinerea (L.) Less. on duodenal smooth muscle of female albino rat suggested the presence of an active ingredient in plant having spasmogenic response that has neurogenic mechanism on rat duodenal smooth muscle. The responses of extract were dose dependent and fully reversible on wash. The findings suggested that the extract responses mediate through agonistic action without blockade of any receptor enzyme. Extract possibly stimulates presynaptic cholinergic nerve endings to produce spasmodic response in rat duodenal smooth muscle.

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Possible involvement of cholinergic and adrenergic mechanisms in changing contractility of guinea pig ileum by Ipomoea carnea

Cited by 2 publications

References 6 publications

The effects of medicinal plants on muscarinic receptors in various types of smooth muscle

The effects of medicinal plants on muscarinic receptors in various types of smooth muscle

Spasmodic response and neurogenic mechanism of water extract of Vernonia cinerea (L.) Less. on rat duodenum

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