Possible involvement of 3-hydroxymethylglutaryl-CoA reductase in determining the side-chain length of ubiquinone in rat heart

Shimizu, Shun-Ichi; Yamamoto, Toshinori; Hiromi, Sugawara; Kawahara, Yoshikazu; Momose, Kazutaka

doi:10.1016/0003-9861(91)90259-l

Cited by 13 publications

(2 citation statements)

References 13 publications

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“…19 It has been also reported that upregulated CoQ10 biosynthesis in the heart is associated with increased activity of HMG-CoA reductase. 20 Lipophilic statins that can enter easily myocardial cells inhibit isoprenoid expression and thereby prevent CoQ10 biosynthesis in the heart. This process could slow down mitochondrial generation of ATP and affect myocardial contraction.…”

Section: Circulation Journal Vol71 September 2007mentioning

confidence: 99%

Usefulness of Hydrophilic vs Lipophilic Statins After Acute Myocardial Infarction Subanalysis of MUSASHI-AMI

Sakamoto

Kojima

Ogawa

et al. 2007

Circ J

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Section: Circulation Journal Vol71 September 2007mentioning

confidence: 99%

Usefulness of Hydrophilic vs Lipophilic Statins After Acute Myocardial Infarction Subanalysis of MUSASHI-AMI

Sakamoto

Kojima

Ogawa

et al. 2007

Circ J

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“…These studies are consistent with the favoured hypothesis that a depletion of isopentenyl diphosphate due to a high rate of cholesterol biosynthesis leads to shorter dolichol chain length because of the lack ofavailable C5 units. Recent studies to establish determinants of isoprenoid side-chain length for ubiquinone biosynthesis in rat heart mitochondria support this hypothesis, namely that isopentenyl diphosphate is limiting for isoprenoid chain elongation [40].…”

Section: Dolichol Chain Lengthmentioning

confidence: 96%

Dolichol biosynthesis in human malignant cells

Henry

Stacpoole

Allen

1991

Biochemical Journal

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Cholesterol, ubiquinone and dolichol biosynthesis from mevalonic acid was measured in non-malignant and malignant cultured human lymphocytes, freshly isolated human mononuclear leucocytes and in cultured human hepatoma cells. The relative flux of mevalonate into ubiquinone, dilichol and cholesterol was not significantly different between malignant and non-malignant cells, although the extent of labelling of each product was an order of magnitude greater in the malignant cultured cells. The most prominent dolichol isolated from total cellular lipid and synthesized in short-term labelling of cultured leukaemic cells had a chain length one isoprene unit shorter than that observed in normal human cells. Cultured human hepatoma cells and mononuclear leucocytes isolated from the peripheral blood of individuals with lymphoblastic and myelogenic leukaemia similarly synthesized shorter-chain dolichols. The dolichols made in cultured non-tumorigenic cells, freshly isolated mononuclear leucocytes from a normal individual or a patient with non-haematological malignancy had normal chain length.

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Regulation of isoprenoid metabolism in rat liver: Near constant chain lengths of dolichyl phosphate and ubiquinone are maintained during greatly altered rates of cholesterogenesis

Keller

Vilsaint

1993

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metaboli

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Possible involvement of 3-hydroxymethylglutaryl-CoA reductase in determining the side-chain length of ubiquinone in rat heart

Cited by 13 publications

References 13 publications

Usefulness of Hydrophilic vs Lipophilic Statins After Acute Myocardial Infarction Subanalysis of MUSASHI-AMI

Usefulness of Hydrophilic vs Lipophilic Statins After Acute Myocardial Infarction Subanalysis of MUSASHI-AMI

Dolichol biosynthesis in human malignant cells

Regulation of isoprenoid metabolism in rat liver: Near constant chain lengths of dolichyl phosphate and ubiquinone are maintained during greatly altered rates of cholesterogenesis

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