Usefulness of Hydrophilic vs Lipophilic Statins After Acute Myocardial Infarction Subanalysis of MUSASHI-AMI

A Randomized Controlled Study to Compare the Effects of Rosuvastatin 5mg and Atorvastatin10mg on the Plasma Lipid Profile in Japanese Patients with Hypercholesterolemia (ASTRO-2)

“…In MUSASHI-AMI (Multicenter Study for Aggressive Lipid-Lowering Strategy by HMG-CoA Reductase Inhibitors in Patients with Acute Myocardial Infarction) Study for hypercholesterolemic patients after the onset of acute myocardial infarction, acute coronary syndrome events occurred lower in hydrophilic statin (pravastatin) than lipophilic statins. 28) From this result, rosuvastatin has the potential to reduce the cardiovascular events more than lipophilic statins. In regard to the safety of statins, it has been reported that although atorvastatin is a widely used statin across the world, it adversely affects the blood glucose level, 29) which suggests that caution should be exercised in administering the drug to patients with diabetes mellitus or with impaired glucose tolerance.…”

"Just Make It Lower" Is an Alternative Strategy of Lipid-Lowering Therapy With Statins in Japanese Patients - LDL-Cholesterol: The Lower, the Better; Is It True for Asians? (Con) -

“…As mentioned before, several statins were used at physicians' discretion in the MUSASHI-AMI trial, consequently enabling a unique subanalysis; namely, comparison of the event rate according to the statins' lipophilicity. 43 In normocholesterolemic Japanese patients after acute MI, hydrophilic pravastatin could be superior to lipophilic statins in reducing cardiovascular events ( Figure 6A) and preventing new Q-wave appearance ( Figure 6B), although the LDL-C reduction rate was higher in the lipophilic statins group as compared with the hydrophilic one (−34% vs −19%). In animal experimental models, pravastatin has proven to be effective in preserving leftventricular function and it could be its hydrophilic property that contributes a great deal to this protective effect.…”

Better Survival With Statin Administration After Revascularization Therapy in Japanese Patients With Coronary Artery Disease Perspectives From the CREDO-Kyoto Registry

“…16,17 The association of statin therapy with better outcomes has also been shown in Japanese patients with AMI or angiographically proven CAD. 18,19 The aim of this study was to assess the preventive effects of medical therapies prescribed at hospital discharge on the long-term prognosis in Japanese CAD patients undergoing their first coronary revascularization by PCI or CABG, with an emphasis on statins.…”